PMID- 27272520
OWN - NLM
STAT- MEDLINE
DCOM- 20171026
LR  - 20220317
IS  - 1479-6813 (Electronic)
IS  - 0952-5041 (Print)
IS  - 0952-5041 (Linking)
VI  - 57
IP  - 2
DP  - 2016 Aug
TI  - Reversal of fortune: estrogen receptor-beta in endometriosis.
PG  - F23-7
LID - 10.1530/JME-16-0080 [doi]
AB  - Enhanced inflammation and reduced apoptosis sustain the growth of endometriotic 
      lesions. Alterations in the expression of estrogen receptor-alpha (ERalpha) and 
      estrogen receptor-beta (ERbeta) accompany the conversion of resident endometrial 
      cells within the normal uterine environment to ectopic lesions located in 
      extrauterine sites. Recent studies highlighted in this focused review linked ERbeta 
      to dysregulation of apoptotic and inflammatory networks involving novel 
      interacting partners in endometriosis. The elucidation of these nongenomic 
      actions of ERbeta using human cells and mouse models is an important step in 
      understanding key regulatory pathways that are disrupted leading to disease 
      establishment and progression.
CI  - (c) 2016 Society for Endocrinology.
FAU - Simmen, Rosalia C M
AU  - Simmen RC
AD  - Department of Physiology and BiophysicsUniversity of Arkansas for Medical 
      Sciences, Little Rock, Arkansas, USA simmenrosalia@uams.edu.
FAU - Kelley, Angela S
AU  - Kelley AS
AD  - Department of Obstetrics and GynecologyUniversity of Michigan Health System, Ann 
      Arbor, Michigan, USA.
LA  - eng
GR  - R01 CA136493/CA/NCI NIH HHS/United States
GR  - UL1 TR000039/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160607
PL  - England
TA  - J Mol Endocrinol
JT  - Journal of molecular endocrinology
JID - 8902617
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Inflammasomes)
SB  - IM
MH  - Animals
MH  - Apoptosis/genetics
MH  - Endometriosis/genetics/*metabolism
MH  - Endometrium/metabolism/pathology
MH  - Estrogen Receptor alpha/genetics/metabolism
MH  - Estrogen Receptor beta/genetics/*metabolism
MH  - Female
MH  - Gene Expression Regulation
MH  - Humans
MH  - Inflammasomes/metabolism
MH  - Inflammation/genetics/metabolism/pathology
MH  - Models, Biological
MH  - Protein Binding
MH  - Signal Transduction
PMC - PMC4973618
MID - NIHMS803679
OTO - NOTNLM
OT  - apoptosome
OT  - endometriosis
OT  - estrogen receptor-beta
OT  - inflammation
OT  - non-genomic
COIS- Declaration of interest The authors declare no potential conflicts of interest.
EDAT- 2016/06/09 06:00
MHDA- 2017/10/27 06:00
PMCR- 2017/08/01
CRDT- 2016/06/09 06:00
PHST- 2016/05/27 00:00 [received]
PHST- 2016/06/07 00:00 [accepted]
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2017/10/27 06:00 [medline]
PHST- 2017/08/01 00:00 [pmc-release]
AID - JME-16-0080 [pii]
AID - 10.1530/JME-16-0080 [doi]
PST - ppublish
SO  - J Mol Endocrinol. 2016 Aug;57(2):F23-7. doi: 10.1530/JME-16-0080. Epub 2016 Jun 
      7.