PMID- 27272774
OWN - NLM
STAT- MEDLINE
DCOM- 20170126
LR  - 20210608
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 36
IP  - 6
DP  - 2016 Jun
TI  - Decreased Expression of Retinoid X Receptors During Human and 
      Azoxymethane-induced Colorectal Carcinogenesis in the Rat.
PG  - 2659-64
AB  - BACKGROUND/AIM: The family of retinoid X receptors (RXRs) including RXRalpha, beta and 
      gamma, is involved in regulating cell proliferation, differentiation, apoptosis and 
      development. MATERIALS AND METHODS: In order to characterize the role of RXRs 
      during colorectal carcinogenesis, the expression of RXRs in human and 
      azoxymethane (AOM)-induced rat colorectal tumors was profiled by 
      immunohistochemistry. RESULTS: Both human and rat normal colorectal epithelia and 
      hyperplasia exhibited strong nuclear, but weak cytoplasmic staining for all three 
      proteins. Expression of RXRalpha, beta and gamma was significantly reduced in rat carcinomas 
      compared to high-grade dysplasia whether in aberrant crypt foci or in adenomas. 
      All three proteins displayed dramatically reduced nuclear expression in both 
      human adenomas and carcinomas. Reduced expression of RXRalpha and RXRgamma seems more 
      significant than RXRbeta in both human and rat carcinomas. CONCLUSION: Reduced 
      expression of RXRs is associated with colorectal carcinogenesis in both humans 
      and AOM-treated rats.
CI  - Copyright(c) 2016 International Institute of Anticancer Research (Dr. John G. 
      Delinassios), All rights reserved.
FAU - Hao, Xingpei
AU  - Hao X
AD  - Susan Lehman Cullman laboratory for Cancer Research, Department of Chemical 
      Biology, Earnest Mario School of Pharmacy, Rutgers, The State University of New 
      Jersey, Piscataway, NJ, U.S.A. xhao@mail.nih.gov.
FAU - Xiao, Hang
AU  - Xiao H
AD  - Susan Lehman Cullman laboratory for Cancer Research, Department of Chemical 
      Biology, Earnest Mario School of Pharmacy, Rutgers, The State University of New 
      Jersey, Piscataway, NJ, U.S.A.
FAU - Ju, Jihyueng
AU  - Ju J
AD  - Susan Lehman Cullman laboratory for Cancer Research, Department of Chemical 
      Biology, Earnest Mario School of Pharmacy, Rutgers, The State University of New 
      Jersey, Piscataway, NJ, U.S.A.
FAU - Hewitt, Stephen M
AU  - Hewitt SM
AD  - Laboratory of Pathology, National Cancer Institute, Bethesda, MD, U.S.A.
FAU - Morse, Herbert C 3rd
AU  - Morse HC 3rd
AD  - Laboratory of Immunogenetics, National Institute of Allergy and Infectious 
      Diseases, Rockville, MD, U.S.A.
LA  - eng
GR  - ZIC BC011638/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Retinoid X Receptors)
RN  - MO0N1J0SEN (Azoxymethane)
SB  - IM
MH  - Animals
MH  - Azoxymethane
MH  - Colorectal Neoplasms/chemically induced/*chemistry/etiology
MH  - Humans
MH  - Intestinal Mucosa/chemistry
MH  - Rats
MH  - Rats, Inbred F344
MH  - Retinoid X Receptors/*analysis
PMC - PMC8183748
MID - NIHMS1705438
OTO - NOTNLM
OT  - RXRs
OT  - carcinogenesis
OT  - colonic cancer
OT  - immunohistochemistry
COIS- Conflicts of Interest None.
EDAT- 2016/06/09 06:00
MHDA- 2017/01/27 06:00
PMCR- 2021/06/07
CRDT- 2016/06/09 06:00
PHST- 2016/04/06 00:00 [received]
PHST- 2016/04/25 00:00 [accepted]
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2017/01/27 06:00 [medline]
PHST- 2021/06/07 00:00 [pmc-release]
AID - 36/6/2659 [pii]
PST - ppublish
SO  - Anticancer Res. 2016 Jun;36(6):2659-64.