PMID- 27273146
OWN - NLM
STAT- MEDLINE
DCOM- 20171011
LR  - 20181202
IS  - 1365-2133 (Electronic)
IS  - 0007-0963 (Linking)
VI  - 176
IP  - 3
DP  - 2017 Mar
TI  - A systematic review of the use of quality-of-life instruments in randomized 
      controlled trials for psoriasis.
PG  - 577-593
LID - 10.1111/bjd.14788 [doi]
AB  - Planners of interventional studies in psoriasis face the dilemma of selecting 
      suitable quality-of-life (QoL) measures. Systematic reviews have the potential of 
      identifying psychometrically sound measures in a given therapeutic area, while 
      guiding the development of practice guidelines. The aim of this systematic review 
      was to generate evidence of the use of QoL instruments in randomized controlled 
      trials (RCTs) for interventions in psoriasis. The methodology followed the PRISMA 
      guidelines. Six databases were searched with 388 search terms. Abstracts of 
      articles were reviewed independently by two assessors, and a third adjudicator 
      resolved any opinion differences. Risk of bias was assessed using the Jadad 
      scale. Of 3646 screened publications, 99 articles (100 trials) met the 
      eligibility criteria for inclusion, describing research on 33 215 patients. 
      Thirty-three trials tested topical therapy, 18 systemic, 39 biologics, nine 
      phototherapy and 10 other interventions. The Dermatology Life Quality Index 
      (DLQI) was the most commonly used QoL instrument (83 studies, 83%), followed by 
      the 36-Item Short Form Survey (SF-36) (31, 31%), EuroQoL-5D (EQ-5D) (15, 15%), 
      Psoriasis Disability Index (14, 14%) and Skindex (five, 5%). There was widespread 
      inconsistency in the way that QoL data were reported. Of the 100 trials 
      identified, 37 reported minimal clinically important difference (MCID): 32 for 
      DLQI, 10 for SF-36 and six for EQ-5D. QoL measurement is increasingly being 
      reported in RCTs of psoriasis. Formal guidelines are needed for assessment and 
      publishing of QoL data. Researchers should consider whether MCID information is 
      available, and development of MCID data should be encouraged.
CI  - (c) 2016 British Association of Dermatologists.
FAU - Ali, F M
AU  - Ali FM
AUID- ORCID: 0000-0002-4184-2023
AD  - Department of Dermatology and Academic Wound Healing, Division of Infection and 
      Immunity, School of Medicine, Cardiff University, 3rd Floor Glamorgan House, 
      Heath Park, Cardiff, CF14 4XN, U.K.
FAU - Cueva, A C
AU  - Cueva AC
AUID- ORCID: 0000-0002-6260-370X
AD  - Department of Dermatology and Academic Wound Healing, Division of Infection and 
      Immunity, School of Medicine, Cardiff University, 3rd Floor Glamorgan House, 
      Heath Park, Cardiff, CF14 4XN, U.K.
AD  - Centro de la Piel, Quito, Ecuador.
FAU - Vyas, J
AU  - Vyas J
AUID- ORCID: 0000-0003-2839-2651
AD  - Department of Dermatology and Academic Wound Healing, Division of Infection and 
      Immunity, School of Medicine, Cardiff University, 3rd Floor Glamorgan House, 
      Heath Park, Cardiff, CF14 4XN, U.K.
FAU - Atwan, A A
AU  - Atwan AA
AUID- ORCID: 0000-0003-2104-6350
AD  - Department of Dermatology and Academic Wound Healing, Division of Infection and 
      Immunity, School of Medicine, Cardiff University, 3rd Floor Glamorgan House, 
      Heath Park, Cardiff, CF14 4XN, U.K.
FAU - Salek, M S
AU  - Salek MS
AUID- ORCID: 0000-0002-4612-5699
AD  - School of Life and Medical Sciences, University of Hertfordshire, Hatfield, U.K.
AD  - Institute for Medicines Development, Cardiff, U.K.
FAU - Finlay, A Y
AU  - Finlay AY
AUID- ORCID: 0000-0003-2143-1646
AD  - Department of Dermatology and Academic Wound Healing, Division of Infection and 
      Immunity, School of Medicine, Cardiff University, 3rd Floor Glamorgan House, 
      Heath Park, Cardiff, CF14 4XN, U.K.
FAU - Piguet, V
AU  - Piguet V
AUID- ORCID: 0000-0001-6079-4517
AD  - Department of Dermatology and Academic Wound Healing, Division of Infection and 
      Immunity, School of Medicine, Cardiff University, 3rd Floor Glamorgan House, 
      Heath Park, Cardiff, CF14 4XN, U.K.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20161012
PL  - England
TA  - Br J Dermatol
JT  - The British journal of dermatology
JID - 0004041
SB  - IM
CIN - Br J Dermatol. 2017 Mar;176(3):563. PMID: 28300302
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Psoriasis/*therapy
MH  - *Quality of Life
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2016/06/09 06:00
MHDA- 2017/10/12 06:00
CRDT- 2016/06/09 06:00
PHST- 2016/05/23 00:00 [accepted]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2017/10/12 06:00 [medline]
PHST- 2016/06/09 06:00 [entrez]
AID - 10.1111/bjd.14788 [doi]
PST - ppublish
SO  - Br J Dermatol. 2017 Mar;176(3):577-593. doi: 10.1111/bjd.14788. Epub 2016 Oct 12.