PMID- 27273235
OWN - NLM
STAT- MEDLINE
DCOM- 20170208
LR  - 20181202
IS  - 1440-169X (Electronic)
IS  - 0012-1592 (Linking)
VI  - 58
IP  - 5
DP  - 2016 Jun
TI  - Brain mesenchymal stem cells: physiology and pathological implications.
PG  - 469-80
LID - 10.1111/dgd.12296 [doi]
AB  - Mesenchymal stem cells (MSCs) are defined as progenitor cells that give rise to a 
      number of unique, differentiated mesenchymal cell types. This concept has 
      progressively evolved towards an all-encompassing concept including multipotent 
      perivascular cells of almost any tissue. In central nervous system, pericytes are 
      involved in blood-brain barrier, and angiogenesis and vascular tone regulation. 
      They form the neurovascular unit (NVU) together with endothelial cells, 
      astrocytes and neurons. This functional structure provides an optimal 
      microenvironment for neural proliferation in the adult brain. Neurovascular niche 
      include both diffusible signals and direct contact with endothelial and 
      pericytes, which are a source of diffusible neurotrophic signals that affect 
      neural precursors. Therefore, MSCs/pericyte properties such as differentiation 
      capability, as well as immunoregulatory and paracrine effects make them a 
      potential resource in regenerative medicine.
CI  - (c) 2016 Japanese Society of Developmental Biologists.
FAU - Pombero, Ana
AU  - Pombero A
AD  - Intituto Murciano de Investigacion Biosanitaria (IMIB)-Arrixaca, University of 
      Murcia, Murcia, Spain.
FAU - Garcia-Lopez, Raquel
AU  - Garcia-Lopez R
AD  - Instituto de Neurociencias, Universidad Miguel Hernandez-Consejo Superior de 
      Investigaciones, Av Ramon y Cajal s/n, San Juan de Alicante, 03550, Spain.
FAU - Martinez, Salvador
AU  - Martinez S
AD  - Instituto de Neurociencias, Universidad Miguel Hernandez-Consejo Superior de 
      Investigaciones, Av Ramon y Cajal s/n, San Juan de Alicante, 03550, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160607
PL  - Japan
TA  - Dev Growth Differ
JT  - Development, growth & differentiation
JID - 0356504
SB  - IM
MH  - Animals
MH  - Astrocytes/metabolism/pathology
MH  - Blood-Brain Barrier/*metabolism/pathology
MH  - *Cell Differentiation
MH  - Endothelial Cells/metabolism/pathology
MH  - Humans
MH  - Mesenchymal Stem Cells/*metabolism/pathology
MH  - Neural Stem Cells/*metabolism/pathology
MH  - Neurons/metabolism/pathology
OTO - NOTNLM
OT  - blood-brain barrier
OT  - cancer
OT  - mesenchymal cells
OT  - neurovascular unit
OT  - pericyte
EDAT- 2016/06/09 06:00
MHDA- 2017/02/09 06:00
CRDT- 2016/06/09 06:00
PHST- 2016/04/28 00:00 [received]
PHST- 2016/05/03 00:00 [revised]
PHST- 2016/05/03 00:00 [accepted]
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
AID - 10.1111/dgd.12296 [doi]
PST - ppublish
SO  - Dev Growth Differ. 2016 Jun;58(5):469-80. doi: 10.1111/dgd.12296. Epub 2016 Jun 
      7.