PMID- 27273357
OWN - NLM
STAT- MEDLINE
DCOM- 20170822
LR  - 20240317
IS  - 1760-4788 (Electronic)
IS  - 1279-7707 (Linking)
VI  - 20
IP  - 6
DP  - 2016
TI  - Parathormone Levels Are Independently Associated with the Presence of Left 
      Ventricular Hypertrophy in Patients with Coronary Artery Disease.
PG  - 659-64
LID - 10.1007/s12603-015-0649-y [doi]
AB  - BACKGROUND: Abnormalities of mineral metabolism and inflammation may affect the 
      cardiovascular system. We have assessed the relationship of left ventricular 
      hypertrophy (LVH) with inflammation and mineral metabolism. METHODS: LVH was 
      measured in 146 outpatients with stable coronary artery disease (SCAD) using 
      echocardiography. Calcidiol (a vitamin D metabolite), parathyroid hormone (PTH), 
      fibroblast growth factor-23, high-sensitivity C-reactive protein, MCP-1 (monocyte 
      chemoattractant protein-1), galectin-3, NGAL (neutrophil gelatinase-associated 
      lipocalin), and sTWEAK (soluble TNF-related weak inducer of apoptosis) plasma 
      levels were studied. RESULTS: LVH, defined as septal thickness >/=11 mm, was 
      present in 19.9% of cases. These patients were older [75.0 (61.0-81.0) vs 64.0 
      (51.0-76.0) years; p=0.002], had higher prevalence of left ventricular ejection 
      fraction (LVEF)>40%, and had higher PTH [84.7 (59.6-104.7) vs 63.2 (49.2-85.2) 
      pg/ml; p=0.007], galectin-3 [9.6 (8.0-11.1) vs 8.3 (6.9-9.9) ng/ml; p=0.037], and 
      NGAL (208.5+/-87.6 vs 173.9+/-73.4 ng/ml; p=0.031) plasma levels than those without 
      LVH. Glomerular filtration rate was lower in patients with LVH than in those 
      without it (65.1+/-20.0 vs 74.7+/-19.9 mL/min/1.73 m2; p=0.021). There were no 
      significant differences in hypertension (79.3 vs 68.4%; p=0.363) or sex between 
      both groups. Variables showing differences based on univariate analysis and 
      hypertension were entered into a logistic regression analysis. Only age [odds 
      ratio (OR) =1.052 (1.011-1.096); p=0.013], PTH plasma levels [OR=1.017 
      (1.003-1.031); p=0.021], and LVEF>40% [OR=7.595 (1.463-39.429); p=0.016] were 
      independent predictors of LVH. CONCLUSIONS: In patients with SCAD, elevated PTH 
      levels are independently associated with the presence of LVH. Further studies are 
      needed to elucidate the role of PTH in the development of myocardial hypertrophy.
FAU - Acena, A
AU  - Acena A
AD  - Jose Tunon, Department of Cardiology, IIS-Fundacion Jimenez Diaz-UAM, Avenida 
      Reyes Catolicos 2, 28040 Madrid, Spain, email: jtunon@secardiologia.es, Phone: 
      00-34-915504800 Ext-3701, Fax 00-34-915504904.
FAU - Pello, A M
AU  - Pello AM
FAU - Carda, R
AU  - Carda R
FAU - Lorenzo, O
AU  - Lorenzo O
FAU - Gonzalez-Casaus, M L
AU  - Gonzalez-Casaus ML
FAU - Blanco-Colio, L M
AU  - Blanco-Colio LM
FAU - Martin-Ventura, J L
AU  - Martin-Ventura JL
FAU - Palfy, J
AU  - Palfy J
FAU - Orejas, M
AU  - Orejas M
FAU - Rabago, R
AU  - Rabago R
FAU - Gonzalez-Parra, E
AU  - Gonzalez-Parra E
FAU - Mahillo-Fernandez, I
AU  - Mahillo-Fernandez I
FAU - Farre, J
AU  - Farre J
FAU - Egido, J
AU  - Egido J
FAU - Tunon, J
AU  - Tunon J
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
RN  - 0 (Parathyroid Hormone)
SB  - IM
MH  - Aged
MH  - Coronary Artery Disease/*complications
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hypertrophy, Left Ventricular/*etiology
MH  - Male
MH  - Middle Aged
MH  - Parathyroid Hormone/*blood
EDAT- 2016/06/09 06:00
MHDA- 2017/08/23 06:00
CRDT- 2016/06/09 06:00
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2017/08/23 06:00 [medline]
AID - S1279-7707(23)00946-6 [pii]
AID - 10.1007/s12603-015-0649-y [doi]
PST - ppublish
SO  - J Nutr Health Aging. 2016;20(6):659-64. doi: 10.1007/s12603-015-0649-y.