PMID- 27273721
OWN - NLM
STAT- MEDLINE
DCOM- 20170619
LR  - 20221207
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 57
IP  - 7
DP  - 2016 Jun 1
TI  - Spectral-Domain Optical Coherence Tomography Features in Open-Angle Glaucoma With 
      Diabetes Mellitus and Inadequate Glycemic Control.
PG  - 3024-31
LID - 10.1167/iovs.16-19457R1 [doi]
AB  - PURPOSE: To evaluate spectral-domain optical coherence tomography (SD-OCT) 
      features according to glycemic control status in open-angle glaucoma with 
      diabetes mellitus. METHODS: Subjects underwent comprehensive ocular examination, 
      visual field testing, and SD-OCT imaging (Cirrus HD-OCT). The relationship 
      between glycosylated hemoglobin (HbA1c) and OCT measurements was compared between 
      diabetic nonglaucomatous eyes and diabetic glaucomatous eyes. 
      Glaucoma-discriminating ability was assessed using the area under the receiver 
      operating characteristic curves (AUCs) for OCT parameters and compared between 
      groups relative to the glycemic control group. RESULTS: Analysis was performed on 
      69 nonglaucomatous and 87 glaucomatous eyes in the nondiabetic group, and on 72 
      nonglaucomatous and 56 glaucomatous eyes in the diabetic group. Average, 
      inferonasal, inferior, and inferotemporal ganglion cell-inner plexiform layer 
      (GCIPL) thicknesses were positively correlated with HbA1c in diabetic 
      nonglaucomatous eyes (P = 0.040, 0.037, 0.025, and 0.013, respectively). The AUC 
      of the average cup-to-disc area ratio (CDR), vertical CDR, and cup volume in 
      diabetic eyes with poor glycemic control was significantly higher than those in 
      nondiabetic eyes (P = 0.011, 0.003, and 0.043, respectively). The AUC of cube 
      volume, cube average thickness, and minimal GCIPL thickness in diabetic eyes with 
      poor glycemic control was lower than those in nondiabetic eyes (P = 0.006, 0.007, 
      and 0.004, respectively). CONCLUSIONS: In this study, optic nerve head parameters 
      had a superior ability to discriminate glaucoma in diabetic eyes with poor 
      glycemic control. Conversely, the ability to discriminate glaucoma using macular 
      parameters tended to be lower for diabetic eyes with inadequate glycemic control.
FAU - Jeong, So Yeon
AU  - Jeong SY
AD  - Department of Ophthalmology and Inha Vision Science Laboratory Inha University 
      School of Medicine, Incheon, Republic of Korea.
FAU - Park, Sang Jun
AU  - Park SJ
AD  - Department of Ophthalmology and Inha Vision Science Laboratory Inha University 
      School of Medicine, Incheon, Republic of Korea.
FAU - Chin, Hee Seung
AU  - Chin HS
AD  - Department of Ophthalmology and Inha Vision Science Laboratory Inha University 
      School of Medicine, Incheon, Republic of Korea.
FAU - Kim, So Hun
AU  - Kim SH
AD  - Department of Endocrinology, Inha University School of Medicine, Incheon, 
      Republic of Korea.
FAU - Kim, Na Rae
AU  - Kim NR
AD  - Department of Ophthalmology and Inha Vision Science Laboratory Inha University 
      School of Medicine, Incheon, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Blood Glucose/analysis
MH  - Cross-Sectional Studies
MH  - Diabetes Complications/diagnosis
MH  - Diabetes Mellitus/*blood
MH  - Female
MH  - Glaucoma, Open-Angle/*diagnostic imaging
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Macula Lutea/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/diagnostic imaging
MH  - *Tomography, Optical Coherence/methods
EDAT- 2016/06/09 06:00
MHDA- 2017/06/20 06:00
CRDT- 2016/06/09 06:00
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2017/06/20 06:00 [medline]
AID - 2527956 [pii]
AID - 10.1167/iovs.16-19457R1 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3024-31. doi: 
      10.1167/iovs.16-19457R1.