PMID- 27274829
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160609
LR  - 20200929
IS  - 2048-8505 (Print)
IS  - 2048-8513 (Electronic)
IS  - 2048-8505 (Linking)
VI  - 9
IP  - 3
DP  - 2016 Jun
TI  - Familial vasculitides: granulomatosis with polyangitis and microscopic 
      polyangitis in two brothers with differing anti-neutrophil cytoplasm antibody 
      specificity.
PG  - 429-31
LID - 10.1093/ckj/sfw016 [doi]
AB  - Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a group 
      of rare autoimmune diseases. Although the aetiology of AAV is uncertain, it is 
      likely that genetic and environmental factors contribute. We report the unusual 
      case of two brothers presenting with AAV with differing clinical pictures and 
      differing ANCA specificity. There is a recently identified difference in genetic 
      risk factors associated with ANCA specificity, making it surprising that 
      first-degree relatives develop AAV with differing clinical and serological 
      features. Our report illustrates the complex aetiology of AAV and suggests that 
      further research on the interaction of genetic and environmental factors is 
      needed.
FAU - Prendecki, Maria
AU  - Prendecki M
AD  - Imperial College Renal and Transplant Centre, Hammersmith Hospital , London , UK.
FAU - Cairns, Tom
AU  - Cairns T
AD  - Imperial College Renal and Transplant Centre, Hammersmith Hospital , London , UK.
FAU - Pusey, Charles D
AU  - Pusey CD
AD  - Imperial College Renal and Transplant Centre, Hammersmith Hospital , London , UK.
LA  - eng
PT  - Case Reports
DEP - 20160414
PL  - England
TA  - Clin Kidney J
JT  - Clinical kidney journal
JID - 101579321
PMC - PMC4886912
OTO - NOTNLM
OT  - ANCA
OT  - familial
OT  - vasculitis
EDAT- 2016/06/09 06:00
MHDA- 2016/06/09 06:01
PMCR- 2016/04/14
CRDT- 2016/06/09 06:00
PHST- 2015/12/02 00:00 [received]
PHST- 2016/02/26 00:00 [accepted]
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2016/06/09 06:01 [medline]
PHST- 2016/04/14 00:00 [pmc-release]
AID - sfw016 [pii]
AID - 10.1093/ckj/sfw016 [doi]
PST - ppublish
SO  - Clin Kidney J. 2016 Jun;9(3):429-31. doi: 10.1093/ckj/sfw016. Epub 2016 Apr 14.