PMID- 27274866
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160609
LR  - 20220316
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2016
DP  - 2016
TI  - Daily Optical Coherence Tomography Examinations after First Antivascular 
      Endothelial Growth Factor Injections: An Interventional Case Series.
PG  - 6971831
LID - 10.1155/2016/6971831 [doi]
LID - 6971831
AB  - Purpose. To evaluate daily spectral-domain optical coherence tomography (SD-OCT) 
      changes in naive-treatment patients with diagnosis of exudative age-related 
      macular degeneration (AMD) treated with intravitreous bevacizumab (1.25 mg), 
      during a 30-day follow-up period. Methods. In prospective, interventional study, 
      SD-OCT was performed daily for 30 days after the first intravitreal injection. 
      The baseline, initial-decrease, minimal, and final central retinal thicknesses 
      (CRTs) were assessed. Results. Nine eyes of nine patients with neovascular AMD 
      were enrolled. The mean baseline CRT was 625.3 +/- 182.5 mum, and the mean final CRT 
      was 383.4 +/- 163.0 mum (mean difference, 206.1 +/- 167.6 mum), a difference that 
      reached significance (P = 0.006). After the first injection, the initial decrease 
      in the CRT was seen as an average of one day after injection (mean CRT, 503.6 +/- 
      189.10 mum; P = 0.0431). The speed of the reduction in the CRT tended to decrease 
      by day 17. The mean CRT was 336.5 +/- 105.44 mum and the mean minimal CRT on day 30 
      was 320.75 +/- 96.38 mum. Conclusion. The CRT decreased early after the first 
      injection. We observed a tendency for reductions in the speed with which the CRT 
      decreased by day 17 after the first injection, which may affect retreatment 
      regime.
FAU - Novais, Eduardo A
AU  - Novais EA
AD  - Department of Ophthalmology, Federal University of Sao Paulo, 04023-062 Sao 
      Paulo, SP, Brazil.
FAU - Badaro, Emmerson
AU  - Badaro E
AD  - Department of Ophthalmology, Federal University of Sao Paulo, 04023-062 Sao 
      Paulo, SP, Brazil.
FAU - Hirai, Flavio E
AU  - Hirai FE
AD  - Department of Ophthalmology, Federal University of Sao Paulo, 04023-062 Sao 
      Paulo, SP, Brazil.
FAU - Jorge, Felipe Abdo
AU  - Jorge FA
AD  - Department of Ophthalmology, Federal University of Sao Paulo, 04023-062 Sao 
      Paulo, SP, Brazil.
FAU - Leal, Paula
AU  - Leal P
AD  - Department of Ophthalmology, Federal University of Sao Paulo, 04023-062 Sao 
      Paulo, SP, Brazil.
FAU - Farah, Michel Eid
AU  - Farah ME
AD  - Department of Ophthalmology, Federal University of Sao Paulo, 04023-062 Sao 
      Paulo, SP, Brazil.
FAU - Rodrigues, Eduardo B
AU  - Rodrigues EB
AD  - Department of Ophthalmology, Federal University of Sao Paulo, 04023-062 Sao 
      Paulo, SP, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20160505
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC4871969
EDAT- 2016/06/09 06:00
MHDA- 2016/06/09 06:01
PMCR- 2016/05/05
CRDT- 2016/06/09 06:00
PHST- 2016/01/14 00:00 [received]
PHST- 2016/03/18 00:00 [revised]
PHST- 2016/04/10 00:00 [accepted]
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2016/06/09 06:01 [medline]
PHST- 2016/05/05 00:00 [pmc-release]
AID - 10.1155/2016/6971831 [doi]
PST - ppublish
SO  - J Ophthalmol. 2016;2016:6971831. doi: 10.1155/2016/6971831. Epub 2016 May 5.