PMID- 27276676
OWN - NLM
STAT- MEDLINE
DCOM- 20180111
LR  - 20231104
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 26
DP  - 2016 Jun 28
TI  - MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 
      8.
PG  - 40644-40656
LID - 10.18632/oncotarget.9811 [doi]
AB  - microRNAs are aberrantly expressed during the development and progression of a 
      variety of human cancers, including colorectal cancer (CRC). Of these microRNAs, 
      microRNA-375 (miR-375) was previously observed to be downregulated in human 
      colorectal cancer(CRC) plasma and tissues, but its functions are largely unknown. 
      Here, we investigated the impact of miR-375 on CRC metastasis. Specifically, 
      miR-375 expression was significantly decreased in human CRC tissues compared with 
      their matched noncancerous tissues (NCTs), and low levels of miR-375 predicted 
      tumor metastatic potential. The up-regulation of miR-375 suppressed colorectal 
      cancer cell migration and invasion in vitro and reduced tumor metastases in 
      murine models established by both orthotopic implantation and spleen injection. 
      Furthermore, we identified Frizzled 8 (FZD8) as a direct target of miR-375 in 
      CRC, and miR-375 negatively regulated Wnt/beta-catenin signaling by suppressing 
      FZD8. More importantly, FZD8 expression inversely correlated with overall 
      survival in human CRC patients and is a likely independent predictor of survival. 
      Therefore, we concluded that miR-375 functions as a tumor-suppressive microRNA by 
      directly acting upon FZD8, which may serve as a new therapeutic target to inhibit 
      tumor metastasis in CRC.
FAU - Xu, Lingling
AU  - Xu L
AD  - Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing 100020, China.
FAU - Wen, Tao
AU  - Wen T
AD  - Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing 100020, China.
FAU - Liu, Zhe
AU  - Liu Z
AD  - Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing 100020, China.
FAU - Xu, Feng
AU  - Xu F
AD  - Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing 100020, China.
FAU - Yang, Lei
AU  - Yang L
AD  - Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing 100020, China.
FAU - Liu, Jian
AU  - Liu J
AD  - Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing 100020, China.
FAU - Feng, Guosheng
AU  - Feng G
AD  - Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing 100020, China.
FAU - An, Guangyu
AU  - An G
AD  - Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing 100020, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (Fzd8 protein, human)
RN  - 0 (MIRN375 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Animals
MH  - Cell Movement
MH  - Colorectal Neoplasms/genetics/*metabolism
MH  - Gene Expression Profiling
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - MicroRNAs/*metabolism
MH  - Neoplasm Invasiveness
MH  - Neoplasm Metastasis
MH  - Prognosis
MH  - Receptors, Cell Surface/*metabolism
MH  - Signal Transduction
MH  - Treatment Outcome
MH  - Up-Regulation
MH  - Wound Healing
PMC - PMC5130033
OTO - NOTNLM
OT  - FZD8
OT  - colorectal cancer
OT  - metastasis
OT  - microRNA-375
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2016/10/26 06:00
MHDA- 2018/01/13 06:00
PMCR- 2016/06/28
CRDT- 2016/06/09 06:00
PHST- 2015/12/20 00:00 [received]
PHST- 2016/05/17 00:00 [accepted]
PHST- 2016/10/26 06:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/28 00:00 [pmc-release]
AID - 9811 [pii]
AID - 10.18632/oncotarget.9811 [doi]
PST - ppublish
SO  - Oncotarget. 2016 Jun 28;7(26):40644-40656. doi: 10.18632/oncotarget.9811.