PMID- 27277213
OWN - NLM
STAT- MEDLINE
DCOM- 20171031
LR  - 20181202
IS  - 1573-2649 (Electronic)
IS  - 0962-9343 (Linking)
VI  - 25
IP  - 12
DP  - 2016 Dec
TI  - Longitudinal assessment of health related quality of life of HIV infected 
      patients treated for tuberculosis and HIV in a high burden setting.
PG  - 3067-3076
AB  - INTRODUCTION: Assessment of patients receiving treatment for human 
      immunodeficiency virus (HIV) and tuberculosis (TB) using a Health Related Quality 
      of Life (HRQoL) instrument is important to get the subjective view of the 
      patients' wellbeing. METHODS: We used the Functional Assessment of HIV Infection 
      (FAHI) HRQoL instrument to collect perceived wellness information at baseline, 
      month 3, 6 and 12 from patients enrolled in a pharmacokinetic study between March 
      2007 and April 2008. Composite domain scores at each time point and their 
      relationship with the rate of adverse events (AEs) and serious adverse events 
      were compared between treatment arms. RESULTS: Out of the 82 patients enrolled, 
      76 were analysed. There was a significant increase in total score in all groups 
      between baseline, month 3, 6 and 12 (all p values < 0.0001), and over time 
      (p < 0.001). Adjusting for baseline total score, baseline CD4 count had a 
      significant effect on the total score over time (p = 0.002) and the rate of 
      change in total score over time, that is; interaction effect (p < 0.001). There 
      was no difference in each domain scores between participants that received ART 
      with TB treatment and those that received TB treatment only. Respiratory AEs had 
      a significant effect on HRQoL. CONCLUSION: We found that assessment of HRQoL of 
      participants in TB-HIV treatment using the FAHI instrument was useful in 
      evaluating treatment responses. It showed improvement consistent with decrease in 
      adverse events and signs and symptoms of TB. Number and type of AEs was related 
      to lower HRQoL in spite of TB cure.
FAU - Mthiyane, Thuli
AU  - Mthiyane T
AUID- ORCID: 0000-0002-1782-5485
AD  - South African Medical Research Council, Durban, South Africa. 
      thulimthiyane24@gmail.com.
FAU - Pym, Alex
AU  - Pym A
AD  - KZN Research Institute for Tuberculosis and HIV, Durban, South Africa.
FAU - Dheda, Keertan
AU  - Dheda K
AD  - Division of Pulmonology, Department of Medicine, University of Cape Town, Cape 
      Town, South Africa.
FAU - Rustomjee, Roxana
AU  - Rustomjee R
AD  - South African Medical Research Council, Durban, South Africa.
FAU - Reddy, T
AU  - Reddy T
AD  - Biostatistics Unit, South African Medical Research Council, Durban, South Africa.
FAU - Manie, Shamila
AU  - Manie S
AD  - Division of Physiotherapy, Department of Health and Rehabilitation Sciences, 
      University of Cape Town, Cape Town, South Africa.
LA  - eng
PT  - Journal Article
DEP - 20160609
PL  - Netherlands
TA  - Qual Life Res
JT  - Quality of life research : an international journal of quality of life aspects of 
      treatment, care and rehabilitation
JID - 9210257
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - HIV Infections/complications/*virology
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Quality of Life/*psychology
MH  - Tuberculosis/*therapy
MH  - Young Adult
OTO - NOTNLM
OT  - Adverse events
OT  - HIV
OT  - Health Related Quality of Life
OT  - Tuberculosis
EDAT- 2016/06/10 06:00
MHDA- 2017/11/01 06:00
CRDT- 2016/06/10 06:00
PHST- 2016/06/02 00:00 [accepted]
PHST- 2016/06/10 06:00 [pubmed]
PHST- 2017/11/01 06:00 [medline]
PHST- 2016/06/10 06:00 [entrez]
AID - 10.1007/s11136-016-1332-4 [pii]
AID - 10.1007/s11136-016-1332-4 [doi]
PST - ppublish
SO  - Qual Life Res. 2016 Dec;25(12):3067-3076. doi: 10.1007/s11136-016-1332-4. Epub 
      2016 Jun 9.