PMID- 27278779
OWN - NLM
STAT- MEDLINE
DCOM- 20180226
LR  - 20181113
IS  - 1435-1250 (Electronic)
IS  - 0340-1855 (Linking)
VI  - 76
IP  - 4
DP  - 2017 May
TI  - Urinary MCP-1 as a biomarker for lupus nephritis: a meta-analysis.
PG  - 357-363
LID - 10.1007/s00393-016-0109-z [doi]
AB  - OBJECTIVE: This study aimed to evaluate whether urinary monocyte chemoattractant 
      protein-1 (MCP-1) could serve as a biomarker for lupus nephritis (LN). METHODS: 
      We performed a meta-analysis to examine the relationship between urinary MCP-1 
      level and LN in three comparisons: active LN versus inactive LN, active LN versus 
      control, and inactive LN versus control. RESULTS: Eight studies of a total of 
      399 patients with LN (204 with active LN, and 195 with inactive LN) and 
      130 controls were available for this meta-analysis. The meta-analysis revealed 
      that the urinary MCP-1 level was significantly higher in the active-LN group than 
      in the inactive-LN group (standard mean difference [SMD] = 1.883, 95 % confidence 
      interval [CI] = 0.811-2.954, p = 0.001). The meta-analysis showed that the 
      urinary MCP-1 level was significantly higher in the active-LN group than in the 
      control group (SMD = 3.085, 95 % CI = 1.684-4.485, p = 1.6 x 10(-5)). 
      Furthermore, stratification by ethnicity showed significantly elevated urinary 
      MCP-1 levels in the active-LN group in Caucasian, Asian, and Egyptian populations 
      (SMD = 2.408, 95 % CI = 1.711-3.105, p < 1.0 x 10(-8); SMD = 1.020, 95 % CI = 
      0.623-2.153, p = 4.6 x 10(-7); and SMD = 7.370, 95 % CI = 1.467-2.157, p = 5.9 x 
      10(-5), respectively). The meta-analysis indicated that the urinary MCP-1 level 
      was also significantly higher in the inactive-LN group than in the control group 
      (SMD = 1.812, 95 % CI = 0.628-2.996, p = 0.003). CONCLUSIONS: The meta-analysis 
      demonstrated that urinary MCP-1 was significantly higher in patients with active 
      LN than in those with inactive LN and control subjects, and the patients with 
      inactive LN showed significantly higher urinary MCP-1 levels than the controls.
FAU - Lee, Y H
AU  - Lee YH
AD  - Division of Rheumatology, Department of Internal Medicine, Korea University 
      Medical Center, Korea University College of Medicine, 73 Inchon-ro, Seongbuk-gu, 
      02841, Seoul, Korea. lyhcgh@korea.ac.kr.
FAU - Song, G G
AU  - Song GG
AD  - Division of Rheumatology, Department of Internal Medicine, Korea University 
      Medical Center, Korea University College of Medicine, 73 Inchon-ro, Seongbuk-gu, 
      02841, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
TT  - MCP-1 im Urin als Biomarker bei Lupusnephritis: eine Metaanalyse.
PL  - Germany
TA  - Z Rheumatol
JT  - Zeitschrift fur Rheumatologie
JID - 0414162
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*urine
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Internationality
MH  - Lupus Nephritis/*diagnosis/epidemiology/*urine
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - Biomarkers
OT  - Inflammation
OT  - Monocyte chemoattractant protein-1
OT  - Systemic lupus erythematosus
OT  - Urinalysis
EDAT- 2016/06/10 06:00
MHDA- 2018/02/27 06:00
CRDT- 2016/06/10 06:00
PHST- 2016/06/10 06:00 [pubmed]
PHST- 2018/02/27 06:00 [medline]
PHST- 2016/06/10 06:00 [entrez]
AID - 10.1007/s00393-016-0109-z [pii]
AID - 10.1007/s00393-016-0109-z [doi]
PST - ppublish
SO  - Z Rheumatol. 2017 May;76(4):357-363. doi: 10.1007/s00393-016-0109-z.