PMID- 27279479
OWN - NLM
STAT- MEDLINE
DCOM- 20170406
LR  - 20170406
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 14
IP  - 2
DP  - 2016 Aug
TI  - Anxiolytic and neuroprotective effects of the Traditional Chinese Medicinal 
      formulation Dan-zhi-xiao-yao-san in a rat model of chronic stress.
PG  - 1247-54
LID - 10.3892/mmr.2016.5382 [doi]
AB  - Dan-zhi-xiao-yao-san is a Traditional Chinese Medicinal formulation widely used 
      for the treatment of neuropsychological disorders. The present study examined the 
      anxiolytic and neuroprotective effects of Dan-zhi-xiao-yao-san in a rat model of 
      chronic stress. The results of an elevated plus maze test showed that 
      Dan‑zhi‑xiao‑yao‑san significantly attenuated the levels of anxiety-induced 
      stress as evidenced by increases in the time spent in the open arm region, as 
      well as the percentage of entries into this area. In addition, 
      Dan-zhi-xiao-yao-san alleviated stress‑induced neuronal death, as indicated by 
      histological examination. Furthermore, mechanistic studies suggested that the 
      anxiolytic and neuroprotective effects of Dan-zhi-xiao-yao-san may be mediated 
      via attenuation of chronic stress‑induced upregulation of alpha‑synuclein and 
      corticosterone, and downregulation of protein phosphatase 2A (PP2A) in the 
      hippocampal region of the brain at the mRNA and protein level. In addition, 
      Dan‑zhi‑xiao‑yao‑san decreased the serum levels of stress‑induced corticosterone 
      in the model animals. In conclusion, the present study demonstrated that 
      Dan‑zhi‑xiao‑yao‑san exerted anxiolytic and neuroprotective effects in a rat 
      model of chronic stress via attenuation of stress‑induced upregulation of 
      alpha‑synuclein and corticosterone, and downregulation of PP2A in the hippocampus.
FAU - Cao, Guo-Ping
AU  - Cao GP
AD  - Department of Basic Medical Science, Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong 510006, P.R. China.
FAU - Gui, Dan
AU  - Gui D
AD  - Department of Basic Medical Science, Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong 510006, P.R. China.
FAU - Fu, Lu-Di
AU  - Fu LD
AD  - Department of Basic Medical Science, Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong 510006, P.R. China.
FAU - Guo, Zhou-Ke
AU  - Guo ZK
AD  - Department of Basic Medical Science, Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong 510006, P.R. China.
FAU - Fu, Wen-Jun
AU  - Fu WJ
AD  - Department of Basic Medical Science, Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong 510006, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20160609
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (alpha-Synuclein)
RN  - EC 3.1.3.16 (Protein Phosphatase 2)
SB  - IM
MH  - Animals
MH  - Anti-Anxiety Agents/*pharmacology
MH  - Anxiety/drug therapy/*psychology
MH  - Behavior, Animal/drug effects
MH  - Brain/drug effects/metabolism/pathology
MH  - Chronic Disease
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Female
MH  - Immunohistochemistry
MH  - Maze Learning/drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Protein Phosphatase 2/metabolism
MH  - Rats
MH  - Stress, Physiological/*drug effects
MH  - Stress, Psychological/drug therapy/*psychology
MH  - alpha-Synuclein/metabolism
EDAT- 2016/06/10 06:00
MHDA- 2017/04/07 06:00
CRDT- 2016/06/10 06:00
PHST- 2015/05/12 00:00 [received]
PHST- 2016/04/08 00:00 [accepted]
PHST- 2016/06/10 06:00 [entrez]
PHST- 2016/06/10 06:00 [pubmed]
PHST- 2017/04/07 06:00 [medline]
AID - 10.3892/mmr.2016.5382 [doi]
PST - ppublish
SO  - Mol Med Rep. 2016 Aug;14(2):1247-54. doi: 10.3892/mmr.2016.5382. Epub 2016 Jun 9.