PMID- 27280339
OWN - NLM
STAT- MEDLINE
DCOM- 20171019
LR  - 20171121
IS  - 1543-8392 (Electronic)
IS  - 1543-8384 (Linking)
VI  - 13
IP  - 7
DP  - 2016 Jul 5
TI  - Triphenylphosphonium Decorated Liposomes and Dendritic Polymers: Prospective 
      Second Generation Drug Delivery Systems for Targeting Mitochondria.
PG  - 2233-41
LID - 10.1021/acs.molpharmaceut.6b00237 [doi]
AB  - Targeting specific intracellular organelles has been a biological process of 
      significant interest. Specifically, for mitochondrial targeting, conventional 
      liposomal and dendritic polymer nanoparticles were selected to be presented in 
      this miniperspective. Both types of nanoparticles were decorated on their 
      external surface with triphenylphosphonium cation (TPP), a well-known and 
      effective mitochondrial targeting moiety. Due to their advantageous specificity 
      toward mitochondria, these nanoparticles may be considered as prospective second 
      generation drug delivery systems (DDSs). Functionalized liposomal and dendritic 
      nanoparticles are conveniently prepared, and although they encounter several 
      hurdles on their route from the extracellular environment to the interior of 
      mitochondria, they manage to be accumulated inside them in experiments in vitro. 
      Therefore, the TPP-functionalized nanoparticles presented in this miniperspective 
      can prove effective DDSs and efforts should be continued to obtain results that 
      will trigger further studies including clinical studies, hopefully leading to 
      effective drugs for mitochondrial diseases. In fact, since these DDSs enter and 
      act at the site where the dysfunction exists, a new medicine subspecialty is 
      emerging, the so-called mitochondrial medicine.
FAU - Paleos, Constantinos M
AU  - Paleos CM
AD  - NCSR "Demokritos", Institute of Nanosciences and Nanotechnology , 15310 Aghia 
      Paraskevi, Attiki, Greece.
AD  - Regulon SA , 7 Afxentiou Street, 17455 Alimos, Attiki Greece.
FAU - Tsiourvas, Dimitris
AU  - Tsiourvas D
AD  - NCSR "Demokritos", Institute of Nanosciences and Nanotechnology , 15310 Aghia 
      Paraskevi, Attiki, Greece.
FAU - Sideratou, Zili
AU  - Sideratou Z
AD  - NCSR "Demokritos", Institute of Nanosciences and Nanotechnology , 15310 Aghia 
      Paraskevi, Attiki, Greece.
LA  - eng
PT  - Journal Article
DEP - 20160622
PL  - United States
TA  - Mol Pharm
JT  - Molecular pharmaceutics
JID - 101197791
RN  - 0 (Drug Carriers)
RN  - 0 (Heterocyclic Compounds)
RN  - 0 (Liposomes)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Polymers)
RN  - 0 (tris(o-phenylenedioxy)cyclotriphosphazene)
SB  - IM
MH  - Drug Carriers/chemistry
MH  - Drug Delivery Systems/methods
MH  - Heterocyclic Compounds/*chemistry
MH  - Humans
MH  - Liposomes/*chemistry/*pharmacology
MH  - Mitochondria/*drug effects
MH  - Nanoparticles/chemistry
MH  - Organophosphorus Compounds/*chemistry
MH  - Polymers/*chemistry
MH  - Prospective Studies
OTO - NOTNLM
OT  - dendritic polymers
OT  - liposomes
OT  - mitochondrial targeting
OT  - triphenylphosphonium cation
EDAT- 2016/06/10 06:00
MHDA- 2017/10/20 06:00
CRDT- 2016/06/10 06:00
PHST- 2016/06/10 06:00 [entrez]
PHST- 2016/06/10 06:00 [pubmed]
PHST- 2017/10/20 06:00 [medline]
AID - 10.1021/acs.molpharmaceut.6b00237 [doi]
PST - ppublish
SO  - Mol Pharm. 2016 Jul 5;13(7):2233-41. doi: 10.1021/acs.molpharmaceut.6b00237. Epub 
      2016 Jun 22.