PMID- 27281542 OWN - NLM STAT- MEDLINE DCOM- 20170306 LR - 20181202 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 159 DP - 2016 Sep TI - Environmental organic pollutants in human milk before and after weight loss. PG - 96-102 LID - S0045-6535(16)30733-0 [pii] LID - 10.1016/j.chemosphere.2016.05.077 [doi] AB - Many persistent organic pollutants (POPs) are banned because they accumulate in organisms and are toxic. Lipophilic POPs are stored in maternal adipose tissue and concentrations in human milk (HM) may increase during weight loss. Our aim was to examine associations between weight loss and concentrations of chlorinated POPs in HM in lactating women participating in a weight loss study. We analysed POPs (PCB 28, PCB 153, HCB, DDE) in HM at 12 and 24 weeks postpartum from 32 women who participated in a randomized, 2 x 2 factorial trial of diet and exercise for postpartum weight loss. Participants donated milk before and after the intervention period. We examined associations between weight loss and change in POP concentrations and estimated the intake of POPs by their breastfed infants. Most (n = 27) women lost weight during intervention, 0.45 +/- 0.30 kg/week (mean +/- SD). Among these women, the concentration of PCB 153 in HM was significantly (p = 0.04) higher at follow-up than at baseline. Weight loss was significantly positively associated with changes in concentrations of all studied POPs (2.0-2.4% increase per percent weight loss). Estimated mean intakes of POPs (ng/day) remained stable because infant milk consumption decreased during the study period. As infants gained weight, estimated mean intakes per kg body weight decreased 17-22%. Changes in concentrations of POPs in HM correlated positively with maternal weight loss, but it is unlikely that the balance between the benefits and risks of breastfeeding will change if the weight loss is restricted to 0.5 kg per week. CI - Copyright (c) 2016 Elsevier Ltd. All rights reserved. FAU - Lignell, Sanna AU - Lignell S AD - Risk Benefit Assessment Department, National Food Agency, PO Box 622, SE-751 26, Uppsala, Sweden. Electronic address: sanna.lignell@slv.se. FAU - Winkvist, Anna AU - Winkvist A AD - Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, PO Box 459, SE-405 30, Gothenburg, Sweden. Electronic address: anna.winkvist@nutrition.gu.se. FAU - Bertz, Fredrik AU - Bertz F AD - Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, PO Box 459, SE-405 30, Gothenburg, Sweden. Electronic address: fredrik.bertz@nutrition.gu.se. FAU - Rasmussen, Kathleen M AU - Rasmussen KM AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA. Electronic address: kathleen.rasmussen@cornell.edu. FAU - Glynn, Anders AU - Glynn A AD - Risk Benefit Assessment Department, National Food Agency, PO Box 622, SE-751 26, Uppsala, Sweden. Electronic address: anders.glynn@slv.se. FAU - Aune, Marie AU - Aune M AD - Chemistry Department, National Food Agency, PO Box 622, SE-751 26, Uppsala, Sweden. Electronic address: marie.aune@slv.se. FAU - Brekke, Hilde Kristin AU - Brekke HK AD - Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, PO Box 459, SE-405 30, Gothenburg, Sweden; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0317, Oslo, Norway. Electronic address: h.k.brekke@medisin.uio.no. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20160607 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (Environmental Pollutants) RN - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Adult MH - Breast Feeding MH - Dichlorodiphenyl Dichloroethylene/*analysis MH - Environmental Pollutants/*analysis MH - Exercise Therapy MH - Female MH - Humans MH - Infant MH - Lactation MH - Milk, Human/*chemistry MH - Overweight/diet therapy/therapy MH - Polychlorinated Biphenyls/*analysis MH - *Weight Loss OTO - NOTNLM OT - Human milk OT - Obese OT - Overweight OT - POPs OT - Postpartum OT - Weight loss EDAT- 2016/06/10 06:00 MHDA- 2017/03/07 06:00 CRDT- 2016/06/10 06:00 PHST- 2016/02/18 00:00 [received] PHST- 2016/05/26 00:00 [revised] PHST- 2016/05/27 00:00 [accepted] PHST- 2016/06/10 06:00 [entrez] PHST- 2016/06/10 06:00 [pubmed] PHST- 2017/03/07 06:00 [medline] AID - S0045-6535(16)30733-0 [pii] AID - 10.1016/j.chemosphere.2016.05.077 [doi] PST - ppublish SO - Chemosphere. 2016 Sep;159:96-102. doi: 10.1016/j.chemosphere.2016.05.077. Epub 2016 Jun 7.