PMID- 27282672
OWN - NLM
STAT- MEDLINE
DCOM- 20181010
LR  - 20181113
IS  - 2149-2271 (Electronic)
IS  - 2149-2263 (Print)
IS  - 2149-2263 (Linking)
VI  - 16
IP  - 6
DP  - 2016 Jun
TI  - Circulating microRNAs in patients with ST-elevation myocardial infarction.
PG  - 392-6
LID - 10.5152/AnatolJCardiol.2015.6603 [doi]
AB  - OBJECTIVE: The aim of this study was to evaluate the expression levels of 
      cardiac-related circulating microRNAs (miRNAs) in ST-elevation myo- cardial 
      infarction (STEMI) patients. METHODS: This study has a prospective experimental 
      cohort design. A total of 12 consecutive patients with acute chest pain within 12 
      h admit- ted to emergency department (STEMI group) and 13 adult patients with 
      normal coronary angiography during the same period were enrolled (control group) 
      in this study. Changes in the expression of miR-122, miR-208, miR-375, miR-22, 
      miR-133b, miR-92b, miR-21, miR-133a, miR-423-5p, miR-27b, miR-30a-3p, miR-17, 
      miR-30d, miR-642, and miR-95 were analyzed using quantitative reverse 
      transcription-polymerase chain reaction. Blood samples were collected before 
      angiography and 24 h after angiography. Data were analyzed using the Statistical 
      Package for the Social Sciences v19. RESULTS: The STEMI group included 12 
      patients (7 males) with an average age of 56.5+/-8.3 (range, 44-69) years. The 
      control group included 13 patients (9 males) with an average age of 59+/-11 (range, 
      42-80) years. When fold differences were calculated for the miRNA expression 
      values, only miR-30d and miR-423-5p expression levels in STEMI patients showed 
      significant differences in expression levels compared with control patients. The 
      miRNA levels were 2.3-fold higher for miR-30d (p=0.034) and 6.9-fold higher for 
      miR-423-5p (p=0.017). There was no significant cor- relation between troponin I 
      and miR-30d or miR-423-5p levels (p>0.05). CONCLUSION: In this study, the 
      expression levels of miRNAs related to cardiac disease were evaluated in 
      peripheral blood. The circulating miR- 423-5p and miR-30d levels in peripheral 
      blood were found to be higher in STEMI cases than in the control group. Further 
      studies should be conducted to evaluate their potential use as biomarkers in 
      STEMI cases.
FAU - Eryilmaz, Ufuk
AU  - Eryilmaz U
AD  - Department of Cardiology, Faculty of Medicine, Adnan Menderes University; 
      Aydin-Turkey. drufukeryilmaz@gmail.com.
FAU - Akgullu, Cagdas
AU  - Akgullu C
AD  - Department of Cardiology, Faculty of Medicine, Adnan Menderes University; 
      Aydin-Turkey.
FAU - Beser, Nurettin
AU  - Beser N
AD  - ADU BILTEM Epidemiology Unit, Faculty of Medicine, Adnan Menderes University; 
      Aydin-Turkey.
FAU - Yildiz, Omer
AU  - Yildiz O
AD  - ADU BILTEM Epidemiology Unit, Faculty of Medicine, Adnan Menderes University; 
      Aydin-Turkey.
FAU - Kurt Omurlu, Imran
AU  - Kurt Omurlu I
AD  - Department of Biostatistics, Adnan Menderes University; Aydin-Turkey.
FAU - Bozdogan, Bulent
AU  - Bozdogan B
AD  - ADU BILTEM Epidemiology Unit, Faculty of Medicine, Adnan Menderes University; 
      Aydin-Turkey.
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Anatol J Cardiol
JT  - Anatolian journal of cardiology
JID - 101652981
RN  - 0 (Biomarkers)
RN  - 0 (Circulating MicroRNA)
RN  - 0 (Troponin I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - Circulating MicroRNA/*analysis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - ST Elevation Myocardial Infarction/*blood
MH  - Troponin I
PMC - PMC5331369
COIS- Conflict of interest: None declared.
EDAT- 2016/06/11 06:00
MHDA- 2018/10/12 06:00
PMCR- 2016/06/01
CRDT- 2016/06/11 06:00
PHST- 2016/06/11 06:00 [entrez]
PHST- 2016/06/11 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - AJC-16-392 [pii]
AID - 10.5152/AnatolJCardiol.2015.6603 [doi]
PST - ppublish
SO  - Anatol J Cardiol. 2016 Jun;16(6):392-6. doi: 10.5152/AnatolJCardiol.2015.6603.