PMID- 2728393
OWN - NLM
STAT- MEDLINE
DCOM- 19890706
LR  - 20220317
IS  - 0042-9007 (Print)
IS  - 0042-9007 (Linking)
VI  - 56
IP  - 3
DP  - 1989
TI  - Prevention of recurrent spontaneous abortion by intravenous immunoglobulin.
PG  - 151-4
AB  - Intravenous immunoglobulin (IVIG) treatment was attempted as a novel therapeutic 
      approach for unexplained recurrent spontaneous abortions (RSA) occurring in the 
      first trimester of pregnancy. Twenty women with a history of RSA were treated 
      with IVIG during pregnancy. Therapy was commenced at week 5 of gestation with 1 
      dose of 0.5-0.6 g IVIG/kg body weight. Infusions were repeated every 3 weeks 
      (0.3-0.4 g/kg) and terminated by week 22 to 24. Of 20 women, 11 delivered healthy 
      infants at term. 5 women are still pregnant, 3 in the third trimester. Only 3 
      patients suffered abortions and 1 presented with ectopic pregnancy. The overall 
      success rate was 82-86%. Thus, the therapeutic effect of IVIG is comparable to 
      that of the conventional transfusion/vaccination regimen with allogeneic 
      leukocytes, but avoids the risk of transmission of infections and/or HLA 
      immunization, has no major adverse effects and is applicable to 'nonresponders'.
FAU - Mueller-Eckhardt, G
AU  - Mueller-Eckhardt G
AD  - Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig 
      University, Giessen, FRG.
FAU - Heine, O
AU  - Heine O
FAU - Neppert, J
AU  - Neppert J
FAU - Kunzel, W
AU  - Kunzel W
FAU - Mueller-Eckhardt, C
AU  - Mueller-Eckhardt C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Abortion, Habitual/*prevention & control
MH  - Adult
MH  - Female
MH  - Humans
MH  - *Immunization, Passive
MH  - Immunoglobulins/*administration & dosage
MH  - Injections, Intravenous
MH  - Pregnancy
MH  - Pregnancy Outcome
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1111/j.1423-0410.1989.tb02018.x [doi]
PST - ppublish
SO  - Vox Sang. 1989;56(3):151-4. doi: 10.1111/j.1423-0410.1989.tb02018.x.