PMID- 27284051
OWN - NLM
STAT- MEDLINE
DCOM- 20170605
LR  - 20220129
IS  - 1470-8752 (Electronic)
IS  - 0300-5127 (Print)
IS  - 0300-5127 (Linking)
VI  - 44
IP  - 3
DP  - 2016 Jun 15
TI  - Rotating with the brakes on and other unresolved features of the vacuolar ATPase.
PG  - 851-5
LID - 10.1042/BST20160043 [doi]
AB  - The rotary ATPase family comprises the ATP synthase (F-ATPase), vacuolar ATPase 
      (V-ATPase) and archaeal ATPase (A-ATPase). These either predominantly utilize a 
      proton gradient for ATP synthesis or use ATP to produce a proton gradient, 
      driving secondary transport and acidifying organelles. With advances in EM has 
      come a significant increase in our understanding of the rotary ATPase family. 
      Following the sub nm resolution reconstructions of both the F- and V-ATPases, the 
      secondary structure organization of the elusive subunit a has now been resolved, 
      revealing a novel helical arrangement. Despite these significant developments in 
      our understanding of the rotary ATPases, there are still a number of unresolved 
      questions about the mechanism, regulation and overall architecture, which this 
      mini-review aims to highlight and discuss.
CI  - (c) 2016 The Author(s).
FAU - Rawson, Shaun
AU  - Rawson S
AD  - School of Biomedical Sciences, Faculty of Biological Sciences, University of 
      Leeds, Leeds LS2 9JT, U.K.
FAU - Harrison, Michael A
AU  - Harrison MA
AD  - School of Biomedical Sciences, Faculty of Biological Sciences, University of 
      Leeds, Leeds LS2 9JT, U.K.
FAU - Muench, Stephen P
AU  - Muench SP
AD  - School of Biomedical Sciences, Faculty of Biological Sciences, University of 
      Leeds, Leeds LS2 9JT, U.K. s.p.muench@leeds.ac.uk.
LA  - eng
GR  - G1000567/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - EC 3.6.1.- (Vacuolar Proton-Translocating ATPases)
SB  - IM
MH  - Animals
MH  - Eukaryota/metabolism
MH  - Vacuolar Proton-Translocating ATPases/*metabolism
PMC - PMC4900747
OTO - NOTNLM
OT  - cryo-EM
OT  - molecular motor
OT  - rotary ATPase
OT  - vacuolar ATPase
EDAT- 2016/06/11 06:00
MHDA- 2017/06/06 06:00
PMCR- 2016/06/09
CRDT- 2016/06/11 06:00
PHST- 2016/02/01 00:00 [received]
PHST- 2016/06/11 06:00 [entrez]
PHST- 2016/06/11 06:00 [pubmed]
PHST- 2017/06/06 06:00 [medline]
PHST- 2016/06/09 00:00 [pmc-release]
AID - BST20160043 [pii]
AID - 10.1042/BST20160043 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2016 Jun 15;44(3):851-5. doi: 10.1042/BST20160043.