PMID- 27284358
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 11
IP  - 6
DP  - 2016 Jun
TI  - HER2-positive gastric cancer identified by serum HER2: A case report.
PG  - 3575-3578
AB  - Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are the 
      current standards methods for the determination of tissue human epidermal growth 
      factor receptor 2 (HER2) status in gastric cancer, as for breast cancer. However, 
      HER2-positive gastric cancer occasionally exhibits heterogeneous tissue HER2 
      overexpression, raising concern regarding false-negative results in unresectable 
      cases diagnosed by biopsy samples. Serum HER2, the concentration of the 
      extracellular domain of HER2 protein shed into the bloodstream, has the potential 
      to supplement the use of IHC or FISH to determine HER2 status. However, the 
      clinical significance of serum HER2 has not been well studied in gastric cancer. 
      The present study describes an illustrative case of metastatic gastric cancer 
      initially diagnosed as HER2-negative (IHC score 1+). The patient exhibited an 
      elevated serum HER2 level, which prompted a reevaluation of the tissue by IHC, 
      using an alternative antibody, and FISH; re-biopsy analyses confirmed the case as 
      HER2-positive, and trastuzumab was subsequently added to the combination 
      chemotherapy with capecitabine and cisplatin. Serum HER2 may aid in avoiding 
      false-negative diagnoses of HER2 gastric cancer.
FAU - Saito, Mayuko
AU  - Saito M
AD  - Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo 
      Medical University, Sapporo, Hokkaido 060-8543, Japan.
FAU - Kawakami, Yujiro
AU  - Kawakami Y
AD  - Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo 
      Medical University, Sapporo, Hokkaido 060-8543, Japan.
FAU - Yamashita, Kentaro
AU  - Yamashita K
AD  - Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo 
      Medical University, Sapporo, Hokkaido 060-8543, Japan.
FAU - Nasuno, Hiroshi
AU  - Nasuno H
AD  - Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo 
      Medical University, Sapporo, Hokkaido 060-8543, Japan.
FAU - Ishimine, Y U
AU  - Ishimine YU
AD  - Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo 
      Medical University, Sapporo, Hokkaido 060-8543, Japan.
FAU - Fukuda, Koichiro
AU  - Fukuda K
AD  - Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo 
      Medical University, Sapporo, Hokkaido 060-8543, Japan.
FAU - Isshiki, Hiroyuki
AU  - Isshiki H
AD  - Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo 
      Medical University, Sapporo, Hokkaido 060-8543, Japan.
FAU - Suzuki, Ryo
AU  - Suzuki R
AD  - Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo 
      Medical University, Sapporo, Hokkaido 060-8543, Japan.
FAU - Arimura, Yoshiaki
AU  - Arimura Y
AD  - Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo 
      Medical University, Sapporo, Hokkaido 060-8543, Japan.
FAU - Shinomura, Yasuhisa
AU  - Shinomura Y
AD  - Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo 
      Medical University, Sapporo, Hokkaido 060-8543, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160419
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC4887934
OTO - NOTNLM
OT  - HER2 overexpression
OT  - false-negative
OT  - gastric cancer
OT  - intratumoral heterogeneity
OT  - sampling error
OT  - serum HER2
EDAT- 2016/06/11 06:00
MHDA- 2016/06/11 06:01
PMCR- 2016/04/19
CRDT- 2016/06/11 06:00
PHST- 2015/01/05 00:00 [received]
PHST- 2016/02/05 00:00 [accepted]
PHST- 2016/06/11 06:00 [entrez]
PHST- 2016/06/11 06:00 [pubmed]
PHST- 2016/06/11 06:01 [medline]
PHST- 2016/04/19 00:00 [pmc-release]
AID - OL-0-0-4470 [pii]
AID - 10.3892/ol.2016.4470 [doi]
PST - ppublish
SO  - Oncol Lett. 2016 Jun;11(6):3575-3578. doi: 10.3892/ol.2016.4470. Epub 2016 Apr 
      19.