PMID- 27287157
OWN - NLM
STAT- MEDLINE
DCOM- 20170406
LR  - 20170812
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 67
DP  - 2016 Oct 1
TI  - Controlled release from thermo-sensitive PNVCL-co-MAA electrospun nanofibers: The 
      effects of hydrophilicity/hydrophobicity of a drug.
PG  - 581-589
LID - S0928-4931(16)30515-X [pii]
LID - 10.1016/j.msec.2016.05.083 [doi]
AB  - The thermo-sensitive copolymer poly(N-vinylcaprolactam-co-methacrylic acid) 
      (PNVCL-co-MAA) was synthesized by free radical polymerization and the resulting 
      nanofibers were fabricated using an electrospinning process. The molecular weight 
      of the copolymer was adjusted by varying the content of methacrylic acid (MAA) 
      while keeping that of N-vinylcaprolactam (NVCL) constant. Hydrophilic captopril 
      and hydrophobic ketoprofen were used as model drugs, and PNVCL-co-MAA nanofibers 
      were used as the drug carrier to investigate the effects of drug on its release 
      properties from nanofibers at different temperatures. The results showed that 
      slow release over several hours was observed at 40 degrees C (above the lower critical 
      solution temperature (LCST) of PNVCL-co-MAA), while the drugs exhibited a burst 
      release of several seconds at 20 degrees C (below the LCST). Drug release slowed with 
      increasing content of the hydrophobic monomer NVCL. The hydrophilic captopril was 
      released at a higher rate than the hydrophobic ketoprofen. The drug release 
      characteristics were dependent on the temperature, the portion of hydrophilic 
      groups and hydrophobic groups in the copolymer and hydrophilicity/hydrophobicity 
      of drug. Study on the mechanism of release showed that Korsmeyer-Peppas model as 
      a major drug release mechanism. Given these results, the PNVCL-co-MAA copolymers 
      are proposed to have useful applications in intellectual drug delivery systems.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Liu, Lin
AU  - Liu L
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai 201620, China; State Key Laboratory for Modification of Chemical Fibers 
      and Polymer Materials, Donghua University, Shanghai 201620, China.
FAU - Bai, Shaoqing
AU  - Bai S
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai 201620, China.
FAU - Yang, Huiqin
AU  - Yang H
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai 201620, China.
FAU - Li, Shubai
AU  - Li S
AD  - Changzhou Institute of Engineering Technology, Changzhou 213164, China.
FAU - Quan, Jing
AU  - Quan J
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai 201620, China.
FAU - Zhu, Limin
AU  - Zhu L
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai 201620, China.
FAU - Nie, Huali
AU  - Nie H
AD  - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 
      Shanghai 201620, China; State Key Laboratory for Modification of Chemical Fibers 
      and Polymer Materials, Donghua University, Shanghai 201620, China. Electronic 
      address: niehuali@dhu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20160519
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Polymers)
RN  - 0 (Polymethacrylic Acids)
RN  - 25087-26-7 (polymethacrylic acid)
RN  - 25189-83-7 (poly-N-vinylcaprolactam)
RN  - 6879X594Z8 (Caprolactam)
RN  - 90Y4QC304K (Ketoprofen)
RN  - 9G64RSX1XD (Captopril)
SB  - IM
MH  - Caprolactam/*analogs & derivatives/chemistry
MH  - *Captopril/chemistry/pharmacokinetics
MH  - Delayed-Action Preparations/chemistry/pharmacokinetics
MH  - *Ketoprofen/chemistry/pharmacokinetics
MH  - Nanofibers/*chemistry
MH  - Polymers/*chemistry
MH  - Polymethacrylic Acids/*chemistry
OTO - NOTNLM
OT  - Controlled release
OT  - Drug delivery
OT  - Electrospinning
OT  - Nanofiber
OT  - Thermo-sensitive
EDAT- 2016/06/12 06:00
MHDA- 2017/04/07 06:00
CRDT- 2016/06/12 06:00
PHST- 2016/04/13 00:00 [received]
PHST- 2016/05/13 00:00 [revised]
PHST- 2016/05/18 00:00 [accepted]
PHST- 2016/06/12 06:00 [entrez]
PHST- 2016/06/12 06:00 [pubmed]
PHST- 2017/04/07 06:00 [medline]
AID - S0928-4931(16)30515-X [pii]
AID - 10.1016/j.msec.2016.05.083 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2016 Oct 1;67:581-589. doi: 
      10.1016/j.msec.2016.05.083. Epub 2016 May 19.