PMID- 27288833
OWN - NLM
STAT- MEDLINE
DCOM- 20171226
LR  - 20230120
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 27 Suppl 23
DP  - 2016 May
TI  - EAACI Molecular Allergology User's Guide.
PG  - 1-250
LID - 10.1111/pai.12563 [doi]
AB  - The availability of allergen molecules ('components') from several protein 
      families has advanced our understanding of immunoglobulin E (IgE)-mediated 
      responses and enabled 'component-resolved diagnosis' (CRD). The European Academy 
      of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide 
      (MAUG) provides comprehensive information on important allergens and describes 
      the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen 
      molecules, families, composition of extracts, databases, and diagnostic IgE, 
      skin, and basophil tests. Singleplex and multiplex IgE assays with components 
      improve both sensitivity for low-abundance allergens and analytical specificity; 
      IgE to individual allergens can yield information on clinical risks and 
      distinguish cross-reactivity from true primary sensitization. Part B discusses 
      the clinical and molecular aspects of IgE-mediated allergies to foods (including 
      nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, 
      and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and 
      Hymenoptera venom. Diagnostic algorithms and short case histories provide useful 
      information for the clinical workup of allergic individuals targeted for CRD. 
      Part C covers protein families containing ubiquitous, highly cross-reactive 
      panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) 
      and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and 
      explains their diagnostic and clinical utility. Part D lists 100 important 
      allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, 
      including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting 
      reactions, are discussed from a novel molecular perspective. The EAACI MAUG 
      documents the rapid progression of molecular allergology from basic research to 
      its integration into clinical practice, a quantum leap in the management of 
      allergic patients.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Matricardi, P M
AU  - Matricardi PM
AD  - Paediatric Pneumology and Immunology, Charite Medical University, Berlin, 
      Germany.
FAU - Kleine-Tebbe, J
AU  - Kleine-Tebbe J
AD  - Allergy & Asthma Center Westend, Outpatient Clinic Ackermann, Hanf, & 
      Kleine-Tebbe, Berlin, Germany.
FAU - Hoffmann, H J
AU  - Hoffmann HJ
AD  - Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, 
      Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
FAU - Valenta, R
AU  - Valenta R
AD  - Division of Immunopathology, Department of Pathophysiology and Allergy Research, 
      Center of Pathophysiology, Infectiology and Immunology, Medical University of 
      Vienna, Vienna, Austria.
FAU - Hilger, C
AU  - Hilger C
AD  - Department of Infection & Immunity, Luxembourg Institute of Health, 
      Esch-sur-Alzette, Luxembourg.
FAU - Hofmaier, S
AU  - Hofmaier S
AD  - Paediatric Pneumology and Immunology, Charite Medical University, Berlin, 
      Germany.
FAU - Aalberse, R C
AU  - Aalberse RC
AD  - Sanquin Research, Department of Immunopathology, Amsterdam, The Netherlands.
AD  - Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 
      Amsterdam, The Netherlands.
FAU - Agache, I
AU  - Agache I
AD  - Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania 
      University of Brasov, Brasov, Romania.
FAU - Asero, R
AU  - Asero R
AD  - Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy.
FAU - Ballmer-Weber, B
AU  - Ballmer-Weber B
AD  - Allergy Unit, Department of Dermatology, University Hospital Zurich, Zurich, 
      Switzerland.
FAU - Barber, D
AU  - Barber D
AD  - IMMA-School of Medicine, University CEU San Pablo, Madrid, Spain.
FAU - Beyer, K
AU  - Beyer K
AD  - Paediatric Pneumology and Immunology, Charite Medical University, Berlin, 
      Germany.
FAU - Biedermann, T
AU  - Biedermann T
AD  - Department of Dermatology and Allergology, Technical University Munich, Munich, 
      Germany.
FAU - Bilo, M B
AU  - Bilo MB
AD  - Allergy Unit, Department of Internal Medicine, University Hospital Ospedali 
      Riuniti di Ancona, Ancona, Italy.
FAU - Blank, S
AU  - Blank S
AD  - Center of Allergy and Environment (ZAUM), Helmholtz Center Munich, Technical 
      University of Munich, Munich, Germany.
FAU - Bohle, B
AU  - Bohle B
AD  - Division of Experimental Allergology, Department of Pathophysiology and Allergy 
      Research, Center of Pathophysiology, Infectiology & Immunology, Medical 
      University of Vienna, Vienna, Austria.
FAU - Bosshard, P P
AU  - Bosshard PP
AD  - Allergy Unit, Department of Dermatology, University Hospital Zurich, Zurich, 
      Switzerland.
FAU - Breiteneder, H
AU  - Breiteneder H
AD  - Department of Pathophysiology and Allergy Research, Medical University of Vienna, 
      Vienna, Austria.
FAU - Brough, H A
AU  - Brough HA
AD  - Paediatric Allergy, Department of Asthma, Allergy and Respiratory Science, King's 
      College London, Guys' Hospital, London, UK.
FAU - Caraballo, L
AU  - Caraballo L
AD  - Institute for Immunological Research, The University of Cartagena, Cartagena de 
      Indias, Colombia.
FAU - Caubet, J C
AU  - Caubet JC
AD  - Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals 
      of Geneva, Geneva, Switzerland.
FAU - Crameri, R
AU  - Crameri R
AD  - Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, 
      Switzerland.
FAU - Davies, J M
AU  - Davies JM
AD  - School of Biomedical Sciences, Institute of Biomedical Innovation, Queensland 
      University of Technology, Brisbane, Qld, Australia.
FAU - Douladiris, N
AU  - Douladiris N
AD  - Allergy Unit, 2nd Paediatric Clinic, National & Kapodistrian University, Athens, 
      Greece.
FAU - Ebisawa, M
AU  - Ebisawa M
AD  - Department of Allergy, Clinical Research Center for Allergology and Rheumatology, 
      Sagamihara National Hospital, Kanagawa, Japan.
FAU - EIgenmann, P A
AU  - EIgenmann PA
AD  - Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals 
      of Geneva, Geneva, Switzerland.
FAU - Fernandez-Rivas, M
AU  - Fernandez-Rivas M
AD  - Allergy Department, Hospital Clinico San Carlos IdISSC, Madrid, Spain.
FAU - Ferreira, F
AU  - Ferreira F
AD  - Division of Allergy and Immunology, Department of Molecular Biology, University 
      of Salzburg, Salzburg, Austria.
FAU - Gadermaier, G
AU  - Gadermaier G
AD  - Division of Allergy and Immunology, Department of Molecular Biology, University 
      of Salzburg, Salzburg, Austria.
FAU - Glatz, M
AU  - Glatz M
AD  - Allergy Unit, Department of Dermatology, University Hospital Zurich, Zurich, 
      Switzerland.
AD  - Christine Kuhne Center for Allergy Research and Education CK-CARE, Davos, 
      Switzerland.
FAU - Hamilton, R G
AU  - Hamilton RG
AD  - Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 
      MD, USA.
FAU - Hawranek, T
AU  - Hawranek T
AD  - Department of Dermatology, Paracelsus Private Medical University, Salzburg, 
      Austria.
FAU - Hellings, P
AU  - Hellings P
AD  - Department of Otorhinolaryngology, Academic Medical Center (AMC), Amsterdam, The 
      Netherlands.
AD  - Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium.
FAU - Hoffmann-Sommergruber, K
AU  - Hoffmann-Sommergruber K
AD  - Department of Pathophysiology and Allergy Research, Medical University of Vienna, 
      Vienna, Austria.
FAU - Jakob, T
AU  - Jakob T
AD  - Department of Dermatology and Allergology, University Medical Center Giessen and 
      Marburg, Justus Liebig University Giessen, Giessen, Germany.
FAU - Jappe, U
AU  - Jappe U
AD  - Division of Clinical and Molecular Allergology, Research Centre Borstel, Airway 
      Research Centre North (ARCN), Member of the German Centre for Lung Research 
      (DZL), Borstel, Germany.
AD  - Interdisciplinary Allergy Division, Department of Pneumology, University of 
      Lubeck, Lubeck, Germany.
FAU - Jutel, M
AU  - Jutel M
AD  - Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wroclaw 
      Medical University, Wroclaw, Poland.
FAU - Kamath, S D
AU  - Kamath SD
AD  - Molecular Allergy Research Laboratory, Centre for Biodiscovery and Molecular 
      Development of Therapeutics, Australian Institute of Tropical Health and 
      Medicine, James Cook University, Townsville City, Qld, Australia.
FAU - Knol, E F
AU  - Knol EF
AD  - Departments of Immunology and Dermatology/Allergology, University Medical Center 
      Utrecht, Utrecht, The Netherlands.
FAU - Korosec, P
AU  - Korosec P
AD  - University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.
FAU - Kuehn, A
AU  - Kuehn A
AD  - Department of Infection & Immunity, Luxembourg Institute of Health, 
      Esch-sur-Alzette, Luxembourg.
FAU - Lack, G
AU  - Lack G
AD  - King's College London, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, 
      London, UK.
AD  - Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation 
      Trust, London, UK.
FAU - Lopata, A L
AU  - Lopata AL
AD  - Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wroclaw 
      Medical University, Wroclaw, Poland.
FAU - Makela, M
AU  - Makela M
AD  - Skin and Allergy Hospital, Helsinki University Central Hospital and University of 
      Helsinki, Helsinki, Finland.
FAU - Morisset, M
AU  - Morisset M
AD  - National Service of Immuno-Allergology, Centre Hospitalier Luxembourg (CHL), 
      Luxembourg, UK.
FAU - Niederberger, V
AU  - Niederberger V
AD  - Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
FAU - Nowak-Wegrzyn, A H
AU  - Nowak-Wegrzyn AH
AD  - Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of 
      Medicine at Mount Sinai, New York, NY, USA.
FAU - Papadopoulos, N G
AU  - Papadopoulos NG
AD  - Centre for Paediatrics and Child Health, Institute of Human Development, 
      University of Manchester, Manchester, UK.
FAU - Pastorello, E A
AU  - Pastorello EA
AD  - Unit of Allergology and Immunology, Niguarda Ca' Granda Hospital, Milan, Italy.
FAU - Pauli, G
AU  - Pauli G
AD  - Service de Pneumologie, Hopitaux Universitaires de Strasbourg, Strasbourg, 
      France.
FAU - Platts-Mills, T
AU  - Platts-Mills T
AD  - Department of Microbiology & Immunology, University of Virginia School of 
      Medicine, Charlottesville, VA, USA.
FAU - Posa, D
AU  - Posa D
AD  - Paediatric Pneumology and Immunology, Charite Medical University, Berlin, 
      Germany.
FAU - Poulsen, L K
AU  - Poulsen LK
AD  - Allergy Clinic, Copenhagen University Hospital, Copenhagen, Denmark.
FAU - Raulf, M
AU  - Raulf M
AD  - Institute for Prevention and Occupational Medicine of the German Social Accident 
      Insurance, Ruhr-University Bochum (IPA), Bochum, Germany.
FAU - Sastre, J
AU  - Sastre J
AD  - Allergy Division, Fundacion Jimenez Diaz, Madrid, Spain.
FAU - Scala, E
AU  - Scala E
AD  - Experimental Allergy Unit, IDI-IRCCS, Rome, Italy.
FAU - Schmid, J M
AU  - Schmid JM
AD  - Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, 
      Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
FAU - Schmid-Grendelmeier, P
AU  - Schmid-Grendelmeier P
AD  - Allergy Unit, Department of Dermatology, University Hospital Zurich, Zurich, 
      Switzerland.
AD  - Christine Kuhne Center for Allergy Research and Education CK-CARE, Davos, 
      Switzerland.
FAU - van Hage, M
AU  - van Hage M
AD  - Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska 
      Institutet and Karolinska University Hospital, Stockholm, Sweden.
FAU - van Ree, R
AU  - van Ree R
AD  - Departments of Experimental Immunology and of Otorhinolaryngology, Academic 
      Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
FAU - Vieths, S
AU  - Vieths S
AD  - Department of Allergology, Paul-Ehrlich-Institut, Langen, Germany.
FAU - Weber, R
AU  - Weber R
AD  - School of Medicine, University of Colorado, Denver, CO, USA.
AD  - Department of Medicine, National Jewish Health Service, Denver, CO, USA.
FAU - Wickman, M
AU  - Wickman M
AD  - Sachs' Children's Hospital, Karolinska Institutet, Stockholm, Sweden.
FAU - Muraro, A
AU  - Muraro A
AD  - The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, 
      Department of Mother and Child Health, University of Padua, Padua, Italy.
FAU - Ollert, M
AU  - Ollert M
AD  - Department of Infection & Immunity, Luxembourg Institute of Health, 
      Esch-sur-Alzette, Luxembourg.
AD  - Department of Dermatology and Allergy Center, Odense Research Center for 
      Anaphylaxis, University of Southern Denmark, Odense, Denmark.
LA  - eng
SI  - GENBANK/AF062651
SI  - GENBANK/AF284645
SI  - GENBANK/AF464911
SI  - GENBANK/AJ001732
SI  - GENBANK/AJ002026
SI  - GENBANK/AJ006689
SI  - GENBANK/AJ223315
SI  - GENBANK/AJ223327
SI  - GENBANK/AJ224333
SI  - GENBANK/AJ224865
SI  - GENBANK/AJ937743
SI  - GENBANK/AJ937744
SI  - GENBANK/AJ937745
SI  - GENBANK/AM496018
SI  - GENBANK/M83781
SI  - GENBANK/PF00261
SI  - GENBANK/U53561
SI  - GENBANK/U56938
SI  - GENBANK/U58050
SI  - GENBANK/U92465
SI  - GENBANK/X85092
SI  - GENBANK/Y13338
SI  - GENBANK/Z11580
SI  - GENBANK/Z30424
PT  - Journal Article
PT  - Practice Guideline
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Biomarkers/metabolism
MH  - Humans
MH  - Hypersensitivity, Immediate/*diagnosis/immunology/metabolism/therapy
MH  - Immunoglobulin E/*metabolism
MH  - Immunologic Tests/methods
MH  - Precision Medicine/methods
OTO - NOTNLM
OT  - IgE
OT  - IgE cross-reactivity
OT  - allergy
OT  - allergy diagnosis
OT  - anaphylaxis
OT  - asthma
OT  - atopic dermatitis
OT  - component-resolved diagnosis
OT  - diagnosis
OT  - diagnostic algorithms
OT  - food allergy
OT  - guidelines
OT  - lipocalins
OT  - microarray
OT  - molecular allergology
OT  - non-specific lipid transfer proteins
OT  - panallergens
OT  - parvalbumins
OT  - pathogenesis-related protein family 10
OT  - polcalcins
OT  - precision medicine
OT  - profilins
OT  - serum albumins
OT  - tropomyosins
EDAT- 2016/06/12 06:00
MHDA- 2017/12/27 06:00
CRDT- 2016/06/12 06:00
PHST- 2016/06/12 06:00 [entrez]
PHST- 2016/06/12 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
AID - 10.1111/pai.12563 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2016 May;27 Suppl 23:1-250. doi: 10.1111/pai.12563.