PMID- 27288891
OWN - NLM
STAT- MEDLINE
DCOM- 20180104
LR  - 20180113
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 63
DP  - 2016 Aug
TI  - Protective role of zinc against the toxicity induced by exposure to cadmium 
      during gestation and lactation on testis development.
PG  - 151-60
LID - S0890-6238(16)30144-7 [pii]
LID - 10.1016/j.reprotox.2016.06.005 [doi]
AB  - To assess the effects of exposure to Cd and Zn on rat testicular development, 
      offspring, from mothers receiving either tap water, Cd, Zn or Cd+Zn during 
      gestation and lactation periods, were observed on gestational day (GD) 20 and on 
      postnatal days (PND) 12, 21 and 35. During gestation, Cd induced maternal 
      hypozincemia and less transfer of Zn to the fetus. During lactation, progressive 
      Cd accumulation and Zn depletion in testis at PND12 and PND21 were noted. An 
      increase of abnormal seminiferous tubules and a decrease in testis weight and 
      plasmatic testosterone concentration were also observed at PND21 and PND35 
      respectively. Interestingly, Zn supply induced a significant protection against 
      Cd toxicity. These results suggest that the toxic effects of Cd observed during 
      development are mediated by the disruption of Zn metabolism, which is established 
      in mothers during pregnancy causing Zn deficiency in fetuses and continues to 
      become more pronounced during lactation.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Chemek, Marouane
AU  - Chemek M
AD  - LR11ES41: Genetique, Biodiversite et Valorisation des Bioressources, Institut de 
      Biotechnologie, Universite de Monastir, 5000 Monastir, Tunisia.
FAU - Mimouna, Safa Ben
AU  - Mimouna SB
AD  - LR11ES41: Genetique, Biodiversite et Valorisation des Bioressources, Institut de 
      Biotechnologie, Universite de Monastir, 5000 Monastir, Tunisia.
FAU - Boughammoura, Sana
AU  - Boughammoura S
AD  - LR11ES41: Genetique, Biodiversite et Valorisation des Bioressources, Institut de 
      Biotechnologie, Universite de Monastir, 5000 Monastir, Tunisia.
FAU - Delbes, Geraldine
AU  - Delbes G
AD  - Institut national de la recherche scientifique, Centre INRS-Institut 
      Armand-Frappier, 531, boulevard des Prairies, Laval (Quebec), Canada.
FAU - Messaoudi, Imed
AU  - Messaoudi I
AD  - LR11ES41: Genetique, Biodiversite et Valorisation des Bioressources, Institut de 
      Biotechnologie, Universite de Monastir, 5000 Monastir, Tunisia. Electronic 
      address: imed_messaoudi@yahoo.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160608
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Environmental Pollutants)
RN  - 0 (Protective Agents)
RN  - 00BH33GNGH (Cadmium)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Cadmium/*toxicity
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Lactation
MH  - Male
MH  - Maternal-Fetal Exchange
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Protective Agents/*pharmacology
MH  - Rats, Wistar
MH  - Testis/*drug effects/growth & development
MH  - Zinc/*pharmacology
OTO - NOTNLM
OT  - Cadmium
OT  - Development
OT  - Gestation
OT  - Lactation
OT  - Testis
OT  - Zinc
EDAT- 2016/06/12 06:00
MHDA- 2018/01/05 06:00
CRDT- 2016/06/12 06:00
PHST- 2016/02/26 00:00 [received]
PHST- 2016/05/17 00:00 [revised]
PHST- 2016/06/07 00:00 [accepted]
PHST- 2016/06/12 06:00 [entrez]
PHST- 2016/06/12 06:00 [pubmed]
PHST- 2018/01/05 06:00 [medline]
AID - S0890-6238(16)30144-7 [pii]
AID - 10.1016/j.reprotox.2016.06.005 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2016 Aug;63:151-60. doi: 10.1016/j.reprotox.2016.06.005. Epub 
      2016 Jun 8.