PMID- 27288971
OWN - NLM
STAT- MEDLINE
DCOM- 20170802
LR  - 20191210
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 219
DP  - 2016 Sep 15
TI  - The influence of confounders in the analysis of mid-regional pro-atrial 
      natriuretic peptide in patients with chronic heart failure.
PG  - 84-91
LID - S0167-5273(16)30899-3 [pii]
LID - 10.1016/j.ijcard.2016.05.006 [doi]
AB  - BACKGROUND: Natriuretic peptides play an important role in the diagnosis and risk 
      stratification of patients with acute and chronic heart failure. Multiple studies 
      have shown that these peptides are liable to the influence of individual factors. 
      For N-terminal-pro-B-type natriuretic peptide (NT-proBNP) some of these 
      confounding factors have been evaluated over the years such as age, gender, New 
      York Heart Association (NYHA) class and body mass index (BMI). The aim of this 
      study was to establish confounding factors of mid-regional pro-atrial natriuretic 
      peptide (MR-proANP) assessment. METHODS AND RESULTS: We studied 684 patients (94% 
      male, age 61.2+/-11.2, left ventricular ejection fraction [LVEF]<35%-45%, NYHA 
      class (I/II/III/IV: 8.4/45.8/39.5/6.3%), ischaemic aetiology 71%, body mass index 
      [BMI] 26.5+/-4.3kg/m(2), mean MR-proANP 296.0+/-281.0pmol/L, mean NT-proBNP 
      2792.0+/-5328.6pg/mL, mean creatinine level 110.2+/-38.0mumol/L and mean haemoglobin 
      13.9+/-1.5g/dL) with clinically stable chronic heart failure. MR-proANP levels 
      increased with increasing NYHA class (p<0.0001) and an increasing BMI category 
      was associated with decreasing values of MR-proANP (p<0.0001). We found MR-proANP 
      to be independently associated with BMI, creatinine, ischaemic aetiology, LVEF 
      and NYHA class. Meanwhile, NT-proBNP was independently associated with BMI, 
      creatinine, haemoglobin, LVEF and NYHA class. CONCLUSION: MR-proANP is subject to 
      the almost identical influencing factors like NT-proBNP. The effects of anaemia 
      warrant further study.
CI  - Copyright (c) 2016. Published by Elsevier Ireland Ltd.
FAU - Kube, Jennifer
AU  - Kube J
AD  - Applied Cachexia Research, Department of Cardiology, Charite Medical School, 
      Campus Virchow-Klinikum, Berlin, Germany.
FAU - Ebner, Nicole
AU  - Ebner N
AD  - Innovative Clinical Trials, Department of Cardiology and Pneumology, University 
      Medical Center Gottingen, Gottingen, Germany.
FAU - Jankowska, Ewa A
AU  - Jankowska EA
AD  - Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
FAU - Rozentryt, Piotr
AU  - Rozentryt P
AD  - 3rd Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia in 
      Katowice, Zabrze, Poland.
FAU - Cicoira, Mariantonietta
AU  - Cicoira M
AD  - Section of Cardiology, Department of Medicine, University of Verona, Verona, 
      Italy.
FAU - Filippatos, Gerasimos S
AU  - Filippatos GS
AD  - Second University Department of Cardiology, Atticon University Hospital, Athens, 
      Greece.
FAU - Ponikowski, Piotr
AU  - Ponikowski P
AD  - Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
FAU - Doehner, Wolfram
AU  - Doehner W
AD  - Center for Stroke Research Berlin, Charite Medical School, Berlin, Germany.
FAU - Anker, Stefan D
AU  - Anker SD
AD  - Innovative Clinical Trials, Department of Cardiology and Pneumology, University 
      Medical Center Gottingen, Gottingen, Germany.
FAU - von Haehling, Stephan
AU  - von Haehling S
AD  - Applied Cachexia Research, Department of Cardiology, Charite Medical School, 
      Campus Virchow-Klinikum, Berlin, Germany; Innovative Clinical Trials, Department 
      of Cardiology and Pneumology, University Medical Center Gottingen, Gottingen, 
      Germany. Electronic address: stephan.von.haehling@web.de.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20160514
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (midregional pro-atrial natriuretic peptide, human)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Aged
MH  - Atrial Natriuretic Factor/*blood
MH  - Biomarkers/blood
MH  - Chronic Disease
MH  - Cohort Studies
MH  - Confounding Factors, Epidemiologic
MH  - Female
MH  - Heart Failure/*blood/diagnosis/*epidemiology
MH  - Humans
MH  - *Internationality
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
OTO - NOTNLM
OT  - Biomarker
OT  - Heart failure
OT  - MR-proANP
OT  - Natriuretic peptides
EDAT- 2016/06/12 06:00
MHDA- 2017/08/03 06:00
CRDT- 2016/06/12 06:00
PHST- 2016/05/02 00:00 [received]
PHST- 2016/05/09 00:00 [accepted]
PHST- 2016/06/12 06:00 [entrez]
PHST- 2016/06/12 06:00 [pubmed]
PHST- 2017/08/03 06:00 [medline]
AID - S0167-5273(16)30899-3 [pii]
AID - 10.1016/j.ijcard.2016.05.006 [doi]
PST - ppublish
SO  - Int J Cardiol. 2016 Sep 15;219:84-91. doi: 10.1016/j.ijcard.2016.05.006. Epub 
      2016 May 14.