PMID- 27289086
OWN - NLM
STAT- MEDLINE
DCOM- 20170512
LR  - 20181113
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Print)
IS  - 0019-2805 (Linking)
VI  - 149
IP  - 1
DP  - 2016 Sep
TI  - Effect of standard tuberculosis treatment on naive, memory and regulatory T-cell 
      homeostasis in tuberculosis-diabetes co-morbidity.
PG  - 87-97
LID - 10.1111/imm.12632 [doi]
AB  - Perturbations in CD4(+) and CD8(+) T-cell phenotype and function are hallmarks of 
      tuberculosis-diabetes co-morbidity. However, their contribution to the 
      pathogenesis of this co-morbidity and the effect of anti-tuberculosis treatment 
      on the phenotype of the T-cell subsets is poorly understood. In this study, we 
      examined the frequency of different T-cell subsets in individuals with pulmonary 
      tuberculosis (PTB) with diabetes mellitus (DM) or without coincident diabetes 
      mellitus (NDM) before, during and after completion of anti-tuberculosis 
      chemotherapy. PTB-DM is characterized by heightened frequencies of central memory 
      CD4(+) and CD8(+) T cells and diminished frequencies of naive, effector memory 
      and/or effector CD4(+) and CD8(+) T cells at baseline and after 2 months of 
      treatment but not following treatment completion in comparison with PTB-NDM. 
      Central memory CD4(+) and CD8(+) T-cell frequencies exhibited a positive 
      correlation with fasting blood glucose and glycated haemoglobin A1c levels, 
      whereas the frequencies of naive and effector memory or effector CD4(+) and 
      CD8(+) T cells exhibited a negative correlation. However, the frequencies of 
      CD4(+) and CD8(+) T-cell subsets in individuals with PTB exhibited no significant 
      relationship with bacterial burdens. Finally, although minor alterations in the 
      T-cell subset compartment were observed at 2 months of treatment, significantly 
      decreased frequencies of central memory and significantly enhanced frequencies of 
      naive CD4(+) and CD8(+) T cells were observed at the completion of treatment. Our 
      data reveal a profound effect of coexistent diabetes on the altered frequencies 
      of central memory, effector memory and naive T cells and its normalization 
      following therapy.
CI  - (c) 2016 John Wiley & Sons Ltd.
FAU - Kumar, Nathella P
AU  - Kumar NP
AD  - National Institutes of Health - NIRT - International Centre for Excellence in 
      Research, Chennai, India.
FAU - Moideen, Kadar
AU  - Moideen K
AD  - National Institutes of Health - NIRT - International Centre for Excellence in 
      Research, Chennai, India.
FAU - Viswanathan, Vijay
AU  - Viswanathan V
AD  - Prof. M. Viswanathan Diabetes Research Centre, Chennai, India.
FAU - Kornfeld, Hardy
AU  - Kornfeld H
AD  - University of Massachusetts Medical School, Worcester, MA, USA.
FAU - Babu, Subash
AU  - Babu S
AD  - National Institutes of Health - NIRT - International Centre for Excellence in 
      Research, Chennai, India.
AD  - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious 
      Diseases, NIH, Bethesda, MD, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160726
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antitubercular Agents/*therapeutic use
MH  - Comorbidity
MH  - Diabetes Complications/*drug therapy/epidemiology
MH  - Female
MH  - Homeostasis
MH  - Humans
MH  - Immunologic Memory
MH  - Male
MH  - Middle Aged
MH  - T-Lymphocyte Subsets/*drug effects/immunology
MH  - T-Lymphocytes, Regulatory/*drug effects/immunology
MH  - Treatment Outcome
MH  - Tuberculosis, Pulmonary/*drug therapy/epidemiology
PMC - PMC4981606
OTO - NOTNLM
OT  - T cells
OT  - bacterial
OT  - diabetes
EDAT- 2016/06/12 06:00
MHDA- 2017/05/13 06:00
PMCR- 2017/09/01
CRDT- 2016/06/12 06:00
PHST- 2016/03/24 00:00 [received]
PHST- 2016/06/07 00:00 [revised]
PHST- 2016/06/07 00:00 [accepted]
PHST- 2016/06/12 06:00 [entrez]
PHST- 2016/06/12 06:00 [pubmed]
PHST- 2017/05/13 06:00 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - IMM12632 [pii]
AID - 10.1111/imm.12632 [doi]
PST - ppublish
SO  - Immunology. 2016 Sep;149(1):87-97. doi: 10.1111/imm.12632. Epub 2016 Jul 26.