PMID- 27291154
OWN - NLM
STAT- MEDLINE
DCOM- 20170501
LR  - 20170501
IS  - 1468-3083 (Electronic)
IS  - 0926-9959 (Linking)
VI  - 30
IP  - 8
DP  - 2016 Aug
TI  - Asymmetrical proliferative pattern loss linked to cyclin D1 overexpression during 
      malignant transformation of the lip epithelium.
PG  - 1315-20
LID - 10.1111/jdv.13671 [doi]
AB  - BACKGROUND: There is inadequate knowledge on the involvement of oncogenic 
      mechanisms linked to the cyclin (CCND1) gene in lip squamous cell carcinoma 
      (LSCC). OBJECTIVE: The aim of this study was to analyse the implication of cyclin 
      D1 in the malignant transformation of lip lesions. METHODS: We 
      immunohistochemically studied 45 actinic cheilitis cases (15 mild dysplasia, 15 
      moderate dysplasia, 15 severe dysplasia/carcinoma in situ), 30 LSCC cases with 
      adjacent non-tumour epithelium and 15 normal oral epithelium samples for 
      detection of cyclin D1, beta-catenin and Ki-67. RESULTS: Cyclin D1 and Ki-67 
      expressions were significantly increased in the basal layer of premalignant 
      epithelia and peripheral layers of tumour nests vs. CONTROLS: Premalignant 
      epithelia had lost their asymmetrical proliferative pattern. CONCLUSION: Lip 
      carcinogenesis was associated with loss of the asymmetrical proliferative 
      pattern, a preventive mechanism against lip oncogenesis, and with cyclin D1 
      overexpression.
CI  - (c) 2016 European Academy of Dermatology and Venereology.
FAU - Garcia, N G
AU  - Garcia NG
AD  - Stomatology Department, Area of Pathology, Bauru School of Dentistry, University 
      of Sao Paulo, Bauru, Sao Paulo, Brazil.
AD  - Oral Medicine Department, School of Dentistry, Instituto de Biomedicina, 
      University of Granada, Granada, Spain.
FAU - Gonzalez-Moles, M A
AU  - Gonzalez-Moles MA
AD  - Oral Medicine Department, School of Dentistry, Instituto de Biomedicina, 
      University of Granada, Granada, Spain.
FAU - Ruiz-Avila, I
AU  - Ruiz-Avila I
AD  - Unidad de Gestion Clinica de Anatomia Patologica, Instituto de Biomedicina de 
      Granada Complejo Hospitalario san Cecilio, Granada, Spain.
FAU - Bravo, M
AU  - Bravo M
AD  - Oral Medicine Department, School of Dentistry, Instituto de Biomedicina, 
      University of Granada, Granada, Spain.
FAU - Ramos-Garcia, P
AU  - Ramos-Garcia P
AD  - Oral Medicine Department, School of Dentistry, Instituto de Biomedicina, 
      University of Granada, Granada, Spain.
FAU - Minicucci, E M
AU  - Minicucci EM
AD  - Pathology Department, Botucatu School of Medicine, State University of Sao Paulo, 
      Botucatu, Sao Paulo, Brazil.
FAU - Domingues, M A C
AU  - Domingues MA
AD  - Pathology Department, Botucatu School of Medicine, State University of Sao Paulo, 
      Botucatu, Sao Paulo, Brazil.
FAU - Oliveira, D T
AU  - Oliveira DT
AD  - Stomatology Department, Area of Pathology, Bauru School of Dentistry, University 
      of Sao Paulo, Bauru, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20160613
PL  - England
TA  - J Eur Acad Dermatol Venereol
JT  - Journal of the European Academy of Dermatology and Venereology : JEADV
JID - 9216037
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Cell Proliferation
MH  - Child
MH  - Cyclin D1/*metabolism
MH  - Female
MH  - Humans
MH  - Lip/metabolism/*pathology
MH  - Lip Neoplasms/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2016/06/14 06:00
MHDA- 2017/05/02 06:00
CRDT- 2016/06/14 06:00
PHST- 2015/09/11 00:00 [received]
PHST- 2016/03/03 00:00 [accepted]
PHST- 2016/06/14 06:00 [entrez]
PHST- 2016/06/14 06:00 [pubmed]
PHST- 2017/05/02 06:00 [medline]
AID - 10.1111/jdv.13671 [doi]
PST - ppublish
SO  - J Eur Acad Dermatol Venereol. 2016 Aug;30(8):1315-20. doi: 10.1111/jdv.13671. 
      Epub 2016 Jun 13.