PMID- 27291327
OWN - NLM
STAT- MEDLINE
DCOM- 20170901
LR  - 20220331
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Print)
IS  - 1368-5031 (Linking)
VI  - 70
IP  - 7
DP  - 2016 Jul
TI  - Telemonitoring in heart failure patients treated by cardiac resynchronisation 
      therapy with defibrillator (CRT-D): the TELECART Study.
PG  - 569-76
LID - 10.1111/ijcp.12823 [doi]
AB  - AIM: Telemonitoring (TM) is a safe and efficient monitoring system for internal 
      cardioverter defibrillator device (ICD) recipients. TM has been used to track 
      info on the clinical status of heart failure patients treated by ICD and/or 
      cardiac resynchronisation therapy defibrillator (CRT-D). The aim of this study 
      was to investigate the impact of TM on clinical outcomes in a population of CRT-D 
      patients with heart failure. METHODS: In a multicentre, randomised study, 
      patients with chronic heart failure, New York Heart Association (NYHA) functional 
      class II or III, left bundle branch block, severe left ventricle ejection 
      fraction reduction (LVEF < 35%) have been identified and screened. RESULTS: One 
      hundred and ninety-one patients have been randomised to receive either a CRT-D 
      with TM or a CRT-D with traditional ambulatory monitoring (control group) and 
      completed the 12-month study follow-up. Primary endpoints were all cause death, 
      cardiac death and hospital admission for heart failure. Secondary endpoints were 
      atrial fibrillation, sustained episodes, non-sustained and self terminated 
      ventricular tachyarrhythmia, sustained ventricular tachycardia, and ventricular 
      fibrillation, ICD shocks and percentage of CRT-D responder patients. Univariate 
      analysis identified the following factors predicting hospitalisation: TM, age, 
      chronic kidney disease, hypercholesterolaemia, LVEF and NYHA class. At 
      multivariate analysis, TM was the only factor predicting heart failure 
      hospitalisation (hazard ratio 0.6, 0.42-0.79, 95% CI, p = 0.002), without 
      affecting overall mortality and cardiac deaths events. CONCLUSIONS: Taken 
      together, our data indicate the importance of TM in predicting heart failure 
      hospitalisation in patients treated with CRT-D.
CI  - (c) 2016 John Wiley & Sons Ltd.
FAU - Sardu, C
AU  - Sardu C
AD  - Department of Arrhythmias and Electrophysiology, 'John Paul II' Research and Care 
      Foundation, Campobasso, Italy.
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
FAU - Santamaria, M
AU  - Santamaria M
AD  - Department of Arrhythmias and Electrophysiology, 'John Paul II' Research and Care 
      Foundation, Campobasso, Italy.
FAU - Rizzo, M R
AU  - Rizzo MR
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
FAU - Barbieri, M
AU  - Barbieri M
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
FAU - di Marino, M
AU  - di Marino M
AD  - Department of Arrhythmias and Electrophysiology, 'John Paul II' Research and Care 
      Foundation, Campobasso, Italy.
FAU - Paolisso, G
AU  - Paolisso G
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
FAU - Santulli, G
AU  - Santulli G
AD  - Columbia University Medical Center, New York, NY, USA.
FAU - Marfella, R
AU  - Marfella R
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      Second University of Naples, Naples, Italy.
LA  - eng
GR  - K99 DK107895/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20160613
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
SB  - IM
MH  - Aged
MH  - *Cardiac Resynchronization Therapy/methods
MH  - Defibrillators, Implantable
MH  - Female
MH  - Heart Failure/mortality/physiopathology/*therapy
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Monitoring, Ambulatory/methods/mortality
MH  - Telemetry/*methods/mortality
PMC - PMC5813682
MID - NIHMS818642
COIS- Disclosures All Authors declare that they have no conflict of interest.
EDAT- 2016/06/14 06:00
MHDA- 2017/09/02 06:00
PMCR- 2018/02/15
CRDT- 2016/06/14 06:00
PHST- 2016/06/14 06:00 [entrez]
PHST- 2016/06/14 06:00 [pubmed]
PHST- 2017/09/02 06:00 [medline]
PHST- 2018/02/15 00:00 [pmc-release]
AID - 10.1111/ijcp.12823 [doi]
PST - ppublish
SO  - Int J Clin Pract. 2016 Jul;70(7):569-76. doi: 10.1111/ijcp.12823. Epub 2016 Jun 
      13.