PMID- 27291710
OWN - NLM
STAT- MEDLINE
DCOM- 20171002
LR  - 20211204
IS  - 1567-7257 (Electronic)
IS  - 1567-1348 (Linking)
VI  - 43
DP  - 2016 Sep
TI  - Association of human leukocyte antigen DP/DQ gene polymorphisms with chronic 
      hepatitis B in Chinese Han and Uygur populations.
PG  - 407-11
LID - S1567-1348(16)30246-5 [pii]
LID - 10.1016/j.meegid.2016.06.022 [doi]
AB  - Several genome-wide association studies (GWAS) have shown that human leukocyte 
      antigen (HLA) DP/DQ gene polymorphisms are associated with susceptibility to 
      chronic hepatitis B virus (HBV) infection. We clarified the roles of the 
      HLA-DP/DQ gene in HBV infection in different nationalities. Three single 
      nucleotide polymorphisms (SNPs) in HLA-DP (rs9277471, rs9277535 and rs9277542) 
      and the SNP rs9272346 in HLA-DQ were studied. In total, 779 patients were 
      recruited to this study, including 400 Chinese Han and 399 Uygurs. The rs9277535 
      variant genotypes were directly associated with HBV persistence compared to 
      healthy controls in an additive model of the Chinese Han population (odds ratio 
      [OR]=1.88, 95% confidence interval [CI]=1.03-3.41, P=0.040), and in a recessive 
      model of the Chinese female population (OR=2.02, 95% CI=1.26-3.24, P=0.003). In 
      addition, rs9277471 and rs9277542 variant genotypes significantly decreased the 
      risk of HBV infection compared to healthy controls in an additive model of the 
      Chinese Han population (OR=0.53, 95% CI=0.29-0.98, P=0.042; OR=0.53, 95% 
      CI=0.29-0.97, P=0.039) and in a dominant model of the Chinese female population 
      (OR=0.50, 95% CI=0.31-0.80, P=0.004; OR=0.49, 95% CI=0.31-0.79, P=0.003). The GG 
      genotype of rs9277346 was associated with HBV infection in the Chinese Han 
      population (additive model: OR=0.38, 95%CI=017-0.82, P=0.014; recessive model: 
      OR=0.41, 95% CI=0.19-0.86, P=0.019) and in males (additive model: OR=0.31, 95% 
      CI=0.14-0.65, P=0.002; dominant model: OR=0.65, 95% CI=0.43-0.97, P=0.034; 
      recessive model: OR=0.36, 95% CI=0.18-0.73, P=0.005). In addition, allele G of 
      rs9277346 was marginally related to a reduction in risk for HBV infection in the 
      Uygur population. Our study suggests that HLA-DP/DQ polymorphisms can affect 
      susceptibility and resistance to HBV infection in Chinese populations, and are 
      possibly linked to race and sex.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Xiang, Xin
AU  - Xiang X
AD  - Centre of Clinical Laboratory, the Traditional Chinese Medicine Hospital of 
      Xinjiang Uygur Autonomous Region, Urumqi, China.
FAU - Guo, Yuxuan
AU  - Guo Y
AD  - Centre of Clinical Laboratory, the Traditional Chinese Medicine Hospital of 
      Xinjiang Uygur Autonomous Region, Urumqi, China.
FAU - Yang, Li
AU  - Yang L
AD  - Centre of Clinical Laboratory, the Traditional Chinese Medicine Hospital of 
      Xinjiang Uygur Autonomous Region, Urumqi, China.
FAU - Ge, Qinghui
AU  - Ge Q
AD  - Centre of Clinical Laboratory, the Traditional Chinese Medicine Hospital of 
      Xinjiang Uygur Autonomous Region, Urumqi, China; College of Traditional Chinese 
      Medicine, Xinjiang Medical University, Urumqi, China.
FAU - Mijit, Sadatgul
AU  - Mijit S
AD  - Centre of Clinical Laboratory, the Traditional Chinese Medicine Hospital of 
      Xinjiang Uygur Autonomous Region, Urumqi, China; College of Traditional Chinese 
      Medicine, Xinjiang Medical University, Urumqi, China.
FAU - Xu, Feili
AU  - Xu F
AD  - Centre of Clinical Laboratory, the Traditional Chinese Medicine Hospital of 
      Xinjiang Uygur Autonomous Region, Urumqi, China. Electronic address: 
      xfl6284@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160609
PL  - Netherlands
TA  - Infect Genet Evol
JT  - Infection, genetics and evolution : journal of molecular epidemiology and 
      evolutionary genetics in infectious diseases
JID - 101084138
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - China
MH  - Ethnicity
MH  - Female
MH  - Gene Expression
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - HLA-DP Antigens/*genetics/immunology
MH  - HLA-DQ Antigens/*genetics/immunology
MH  - Haplotypes
MH  - Hepatitis B virus/growth & development/pathogenicity
MH  - Hepatitis B, Chronic/ethnology/*genetics/immunology/virology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Chronic hepatitis B
OT  - HLA-DP/DQ
OT  - Single nucleotide polymorphism
EDAT- 2016/06/14 06:00
MHDA- 2017/10/03 06:00
CRDT- 2016/06/14 06:00
PHST- 2016/01/22 00:00 [received]
PHST- 2016/05/31 00:00 [revised]
PHST- 2016/06/07 00:00 [accepted]
PHST- 2016/06/14 06:00 [entrez]
PHST- 2016/06/14 06:00 [pubmed]
PHST- 2017/10/03 06:00 [medline]
AID - S1567-1348(16)30246-5 [pii]
AID - 10.1016/j.meegid.2016.06.022 [doi]
PST - ppublish
SO  - Infect Genet Evol. 2016 Sep;43:407-11. doi: 10.1016/j.meegid.2016.06.022. Epub 
      2016 Jun 9.