PMID- 27294086
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160613
LR  - 20201001
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 4
IP  - 10
DP  - 2016 May
TI  - Lower mean corpuscular hemoglobin concentration is associated with poorer 
      outcomes in intensive care unit admitted patients with acute myocardial 
      infarction.
PG  - 190
LID - 10.21037/atm.2016.03.42 [doi]
LID - 190
AB  - BACKGROUND: Accumulated studies have shown that hematological parameters [e.g., 
      red blood cell distribution width (RDW), hemoglobin, platelet count] and serum 
      potassium level can impact the prognosis of patients with acute myocardial 
      infarction (AMI). However, no previous study has evaluated the prognostic values 
      of these laboratory tests simultaneously. METHODS: This study is based on an 
      intensive care unit (ICU) database named Multiparameter Intelligent Monitoring in 
      Intensive Care II (MIMIC II). Adult patients with AMI were included, and their 
      hematological parameters and serum ion levels on admission were extracted. The 
      relationships between these laboratory tests and hospital mortality were 
      evaluated using a logistic regression model and receiver operating characteristic 
      (ROC) curve analysis. The effects of these laboratory tests on 1-year mortality 
      were evaluated using a Cox hazard regression model and Kaplan-Meier curve 
      analysis. RESULTS: In univariable analysis, increased white blood cell (WBC), 
      neutrophil percentage, mean corpuscular volume (MCV), RDW, potassium and 
      decreased red blood cell (RBC), hemoglobin, mean corpuscular hemoglobin 
      concentration (MCHC), hematocrit and percentage of lymphocyte, monocyte, basophil 
      and eosinophil were significantly associated with hospital mortality. In 
      multivariable analyses, basophil percentage, potassium, WBC and MCHC were 
      independently associated with hospital morality, while WBC, RDW, MCHC, potassium 
      and percentages of neutrophil and lymphocyte were associated with 1-year 
      mortality. CONCLUSIONS: Hematological parameters and serum potassium can provide 
      prognostic information in AMI patients. MCHC is an independent prognostic factor 
      for both short and long term outcomes of AMI.
FAU - Huang, Yuan-Lan
AU  - Huang YL
AD  - 1 Department of Laboratory Medicine, No. 455 Hospital of the Chinese People's 
      Liberation Army, Shanghai 200052, China ; 2 Department of Laboratory Medicine, 
      the General Hospital of Ji'nan Military Command Region, Ji'nan 250031, China.
FAU - Hu, Zhi-De
AU  - Hu ZD
AD  - 1 Department of Laboratory Medicine, No. 455 Hospital of the Chinese People's 
      Liberation Army, Shanghai 200052, China ; 2 Department of Laboratory Medicine, 
      the General Hospital of Ji'nan Military Command Region, Ji'nan 250031, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC4885905
OTO - NOTNLM
OT  - Acute myocardial infarction (AMI)
OT  - hematological parameter
OT  - mean corpuscular hemoglobin concentration (MCHC)
OT  - potassium
OT  - prognosis
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2016/06/14 06:00
MHDA- 2016/06/14 06:01
PMCR- 2016/05/01
CRDT- 2016/06/14 06:00
PHST- 2016/06/14 06:00 [entrez]
PHST- 2016/06/14 06:00 [pubmed]
PHST- 2016/06/14 06:01 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - atm-04-10-190 [pii]
AID - 10.21037/atm.2016.03.42 [doi]
PST - ppublish
SO  - Ann Transl Med. 2016 May;4(10):190. doi: 10.21037/atm.2016.03.42.