PMID- 27294943
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20221207
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 13
IP  - 6
DP  - 2016 Jun 9
TI  - Association between IGF2BP2 Polymorphisms and Type 2 Diabetes Mellitus: A 
      Case-Control Study and Meta-Analysis.
LID - 10.3390/ijerph13060574 [doi]
LID - 574
AB  - BACKGROUND: Genome-wide association studies (GWAS) found that IGF2BP2 rs4402960 
      and rs1470579 polymorphisms were associated with type 2 diabetes mellitus (T2DM) 
      risk. Many studies have replicated this association, but yielded inconsistent 
      results. MATERIALS AND METHODS: A case-control study consisting of 461 T2DM 
      patients and 434 health controls was conducted to detect the genetic 
      susceptibility of IGF2BP2 in a northern Han Chinese population. A meta-analysis 
      was to evaluate the association more precisely in Asians. RESULTS: In the 
      case-control study, the carriers of TT genotype at rs4402960 had a higher T2DM 
      risk than the G carriers (TG + GG) (adjusted odd ratio (AOR) = 1.962, 95% 
      confidence interval (95% CI) = 1.065-3.612, p = 0.031]; CC carriers at rs1470579 
      were more susceptible to T2DM than A carriers (CA + AA) (AOR = 2.014, 95% CI = 
      1.114-3.642, p = 0.021). The meta-analysis containing 36 studies demonstrated 
      that the two polymorphisms were associated with T2DM under the allele comparison, 
      genetic models of dominant and recessive in Asians (p < 0.05). The rs4402960 
      polymorphisms were significantly associated with the T2DM risk after 
      stratification by diagnostic criterion, size of sample and average age and BMI of 
      cases, while there're no consistent results for rs1470579. CONCLUSIONS: Our data 
      suggests that IGF2BP2 polymorphisms are associated with T2DM in Asian 
      populations.
FAU - Rao, Ping
AU  - Rao P
AD  - School of Public Health, Capital Medical University, Beijing 100069, China. 
      raopingbj@126.com.
FAU - Wang, Hao
AU  - Wang H
AD  - School of Public Health, Capital Medical University, Beijing 100069, China. 
      wanghaostudy@163.com.
FAU - Fang, Honghong
AU  - Fang H
AD  - School of Public Health, Capital Medical University, Beijing 100069, China. 
      fanghonghong79@sina.com.
FAU - Gao, Qing
AU  - Gao Q
AD  - School of Public Health, Capital Medical University, Beijing 100069, China. 
      shouyigaoqing@163.com.
FAU - Zhang, Jie
AU  - Zhang J
AD  - School of Public Health, Capital Medical University, Beijing 100069, China. 
      zhangjie@ccmu.edu.cn.
FAU - Song, Manshu
AU  - Song M
AD  - School of Public Health, Capital Medical University, Beijing 100069, China. 
      songms@ccmu.edu.cn.
FAU - Zhou, Yong
AU  - Zhou Y
AD  - Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen 
      Hospital, Capital Medical University, Beijing 100029, China. 
      yongzhou78214@163.com.
FAU - Wang, Youxin
AU  - Wang Y
AD  - School of Public Health, Capital Medical University, Beijing 100069, China. 
      wangy@ccmu.edu.cn.
FAU - Wang, Wei
AU  - Wang W
AD  - School of Public Health, Capital Medical University, Beijing 100069, China. 
      wei.wang@ecu.edu.au.
AD  - School of Medical Sciences, Edith Cowan University, Perth, WA 6027, Australia. 
      wei.wang@ecu.edu.au.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20160609
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (IGF2BP2 protein, human)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Adult
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/epidemiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - RNA-Binding Proteins/*genetics
MH  - Risk
PMC - PMC4924031
OTO - NOTNLM
OT  - Asian
OT  - IGF2BP2
OT  - case-control study
OT  - meta-analysis
OT  - type 2 diabetes mellitus
EDAT- 2016/06/15 06:00
MHDA- 2017/07/25 06:00
PMCR- 2016/06/01
CRDT- 2016/06/14 06:00
PHST- 2016/02/20 00:00 [received]
PHST- 2016/05/26 00:00 [revised]
PHST- 2016/06/01 00:00 [accepted]
PHST- 2016/06/14 06:00 [entrez]
PHST- 2016/06/15 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - ijerph13060574 [pii]
AID - ijerph-13-00574 [pii]
AID - 10.3390/ijerph13060574 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2016 Jun 9;13(6):574. doi: 
      10.3390/ijerph13060574.