PMID- 27295130
OWN - NLM
STAT- MEDLINE
DCOM- 20171121
LR  - 20211204
IS  - 1873-4847 (Electronic)
IS  - 0955-2863 (Linking)
VI  - 34
DP  - 2016 Aug
TI  - Zinc stimulates glucose consumption by modulating the insulin signaling pathway 
      in L6 myotubes: essential roles of Akt-GLUT4, GSK3beta and mTOR-S6K1.
PG  - 126-35
LID - S0955-2863(16)30107-3 [pii]
LID - 10.1016/j.jnutbio.2016.05.008 [doi]
AB  - The present study was performed to evaluate the insulin-like effects of zinc in 
      normal L6 myotubes as well as its ability to alleviate insulin resistance. 
      Glucose consumption was measured in both normal and insulin-resistant L6 
      myotubes. Western blotting and immunofluorescence revealed that zinc exhibited 
      insulin-like glucose transporting effects by activating key markers that are 
      involved in the insulin signaling cascade (including Akt, GLUT4 and GSK3beta), and 
      downregulating members of the insulin signaling feedback cascade such as 
      mammalian target of rapamycin (mTOR) and ribosomal protein S6 kinase (S6K1). In 
      normal L6 myotubes, zinc enhanced glucose consumption via a mechanism that might 
      involve the activation of Akt phosphorylation, glucose transporter 4 (GLUT4) 
      translocation and GSK3beta phosphorylation. In contrast, zinc exerted 
      insulin-mimetic effects in insulin-resistant L6 myotubes by upregulating Akt 
      phosphorylation, GLUT4 translocation and GSK3beta phosphorylation, and 
      downregulating the expression of mTOR and S6K1. In conclusion, zinc might enhance 
      glucose consumption by modulating insulin signaling pathways including Akt-GLUT4, 
      GSK3beta, mTOR and S6K1.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Wu, Yuntang
AU  - Wu Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin 
      Medical University, Tianjin, China. Electronic address: Wuyuntang@tmu.edu.cn.
FAU - Lu, Huizi
AU  - Lu H
AD  - Tanggu Centers for Disease Control and Prevention, Tianjin Binhai New 
      Area,Tianjin, China.
FAU - Yang, Huijun
AU  - Yang H
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Li, Chunlei
AU  - Li C
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Sang, Qian
AU  - Sang Q
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Liu, Xinyan
AU  - Liu X
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Liu, Yongzhe
AU  - Liu Y
AD  - Department of Toxicology, School of Public Health, Tianjin Medical University, 
      Tianjin, China.
FAU - Wang, Yongming
AU  - Wang Y
AD  - Department of Toxicology, School of Public Health, Tianjin Medical University, 
      Tianjin, China.
FAU - Sun, Zhong
AU  - Sun Z
AD  - Department of Epidemiology and biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
LA  - eng
PT  - Journal Article
DEP - 20160531
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Biomarkers)
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Slc2a4 protein, rat)
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
RN  - EC 2.7.11.1 (Gsk3b protein, rat)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases)
RN  - EC 2.7.11.1 (Rps6kb1 protein, rat)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - IY9XDZ35W2 (Glucose)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Absorption, Physiological
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cell Line
MH  - Dietary Supplements
MH  - Enzyme Activation
MH  - Glucose/metabolism
MH  - Glucose Transporter Type 4/*agonists/metabolism
MH  - Glycogen Synthase Kinase 3 beta/chemistry/*metabolism
MH  - *Insulin Resistance
MH  - Muscle Fibers, Skeletal/cytology/enzymology/*metabolism
MH  - Phosphorylation
MH  - Protein Processing, Post-Translational
MH  - Protein Transport
MH  - Proto-Oncogene Proteins c-akt/*agonists/metabolism
MH  - Rats
MH  - Ribosomal Protein S6 Kinases/antagonists & inhibitors/metabolism
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/antagonists & inhibitors/metabolism
MH  - Zinc/*metabolism
OTO - NOTNLM
OT  - Akt
OT  - GSK3beta
OT  - Glucose consumption
OT  - Insulin signaling pathway
OT  - L6 myotubes
OT  - Zinc
OT  - mTOR
EDAT- 2016/06/14 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/06/14 06:00
PHST- 2015/11/10 00:00 [received]
PHST- 2016/05/10 00:00 [revised]
PHST- 2016/05/17 00:00 [accepted]
PHST- 2016/06/14 06:00 [entrez]
PHST- 2016/06/14 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - S0955-2863(16)30107-3 [pii]
AID - 10.1016/j.jnutbio.2016.05.008 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2016 Aug;34:126-35. doi: 10.1016/j.jnutbio.2016.05.008. Epub 2016 
      May 31.