PMID- 27295311
OWN - NLM
STAT- MEDLINE
DCOM- 20170413
LR  - 20220310
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 64
IP  - 26
DP  - 2016 Jul 6
TI  - alpha-Tocopherol Attenuates the Triglyceride- and Cholesterol-Lowering Effects of 
      Rice Bran Tocotrienol in Rats Fed a Western Diet.
PG  - 5361-6
LID - 10.1021/acs.jafc.6b02228 [doi]
AB  - Previous studies demonstrated the ability of tocotrienol (T3) to lower levels of 
      lipids, including cholesterol (Cho) and triglycerides (TG). Although alpha-tocopherol 
      (alpha-Toc) reportedly inhibits the hypocholesterolemic effect of T3, there is no 
      information about whether alpha-Toc influences the TG-lowering effect of T3 in vivo. 
      In this study, we investigated the influence of alpha-Toc on the antihyperlipidemic 
      effects (Cho- and TG-lowering) of rice bran tocotrienols (RBT3) in F344 rats fed 
      a western diet. alpha-Toc attenuated both the Cho- and TG-lowering effects of RBT3 in 
      vivo, whereas alpha-Toc alone exhibited no hypolipidemic effects. RBT3-induced Cpt-1a 
      and Cyp7a1 gene expression was reduced by alpha-Toc. Furthermore, coadministration of 
      alpha-Toc decreased liver and adipose tissue concentrations of tocotrienols in F344 
      rats. These results indicate that alpha-Toc has almost no antihyperlipidemic effect 
      in vivo, but abrogates the antihyperlipidemic effect of RBT3 by reducing tissue 
      concentrations of tocotrienols and regulating expression of genes involved in 
      lipid metabolism. Understanding the underlying mechanism of the beneficial 
      effects of T3 on lipid metabolism and the interaction with alpha-Toc will be 
      important for developing T3-based therapeutics.
FAU - Shibata, Akira
AU  - Shibata A
AD  - Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural 
      Science, Tohoku University , Sendai 981-8555, Japan.
FAU - Kawakami, Yuki
AU  - Kawakami Y
AD  - Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama 
      Prefectural University , Okayama 719-1197, Japan.
FAU - Kimura, Toshiyuki
AU  - Kimura T
AD  - Division of Food Function Research, Food Research Institute, NARO , Tsukuba, 
      Ibaraki 305-8642, Japan.
FAU - Miyazawa, Teruo
AU  - Miyazawa T
AD  - Food and Biotechnology Innovation Project, New Industry Creation Hatchery Center 
      (NICHe), Tohoku University , Sendai 980-8579, Japan.
AD  - Food and Health Science Research Unit, Graduate School of Agricultural Science, 
      Tohoku University , Sendai 981-8555, Japan.
FAU - Nakagawa, Kiyotaka
AU  - Nakagawa K
AD  - Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural 
      Science, Tohoku University , Sendai 981-8555, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160621
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Plant Extracts)
RN  - 0 (Tocotrienols)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 2.3.1.21 (Carnitine O-Palmitoyltransferase)
RN  - EC 2.3.1.21 (carnitine palmitoyltransferase-1a, rat)
RN  - H4N855PNZ1 (alpha-Tocopherol)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - Carnitine O-Palmitoyltransferase/genetics/metabolism
MH  - Cholesterol/*metabolism
MH  - Diet, Western/adverse effects
MH  - Dyslipidemias/*drug therapy/metabolism
MH  - Humans
MH  - Liver/metabolism
MH  - Male
MH  - Oryza/*chemistry
MH  - Plant Extracts/*administration & dosage
MH  - Rats
MH  - Rats, Inbred F344
MH  - Tocotrienols/*administration & dosage
MH  - Triglycerides/*metabolism
MH  - alpha-Tocopherol/*administration & dosage
OTO - NOTNLM
OT  - F344 rat
OT  - cholesterol
OT  - tocopherol
OT  - tocotrienol
OT  - triglyceride
EDAT- 2016/06/14 06:00
MHDA- 2017/04/14 06:00
CRDT- 2016/06/14 06:00
PHST- 2016/06/14 06:00 [entrez]
PHST- 2016/06/14 06:00 [pubmed]
PHST- 2017/04/14 06:00 [medline]
AID - 10.1021/acs.jafc.6b02228 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2016 Jul 6;64(26):5361-6. doi: 10.1021/acs.jafc.6b02228. Epub 
      2016 Jun 21.