PMID- 27296256
OWN - NLM
STAT- MEDLINE
DCOM- 20160824
LR  - 20181023
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 88
IP  - 6
DP  - 2016
TI  - [Acute kidney injury and tubular biomarkers after hematopoietic stem cell 
      transplantation].
PG  - 14-20
LID - 10.17116/terarkh201688614-20 [doi]
AB  - AIM: To determine the value of molecular biomarkers (BMs) associated with tubular 
      epithelial damage in developing and predicting acute kidney injury (AKI) after 
      hematopoietic stem cell transplantation (HSCT). SUBJECTS AND METHODS: The 
      open-label observational prospective study enrolled 90 patients (46 males and 44 
      females) who had undergone HSCT. The concentrations of BMs (calbindin, clusterin, 
      interleukin-18 (IL-18), kidney injury molecules-1 (KIM-1), glutathione 
      S-transferase-pi (GST-pi), and monocyte chemoattractant protein-1 (MCP-1) were 
      measured in urinary samples 7 days before HSCT (week 0) and at weeks 1, 2, 3, 4, 
      and 5. Main clinical parameters were simultaneously monitored. AKI was diagnosed 
      and stratified according to the Kidney Disease Improving Global Outcomes (KDIGO) 
      guidelines. RESULTS: At weeks 1, 2, 3, 4, and 5 after HSCT, the proportion of AKI 
      cases was 7.8, 8.9, 12.5, 27.3, and 35.9%, respectively. The elevated urinary 
      levels of BMs (above the median) were found to be substantially more common than 
      AKI cases. The urinary excretion of the majority of BMs dramatically increased in 
      the early HSCT period. The median number of simultaneously elevated BMs was 3 (2; 
      5) during the entire follow-up period. Clusterin, MCP-1 and KIM-1 positively and 
      significantly correlated with serum creatinine at the week following the 
      determination of BMs in the multivariate linear regression models adjusted for 
      other confounders. The higher urinary KIM-1 and/or MCP-1 excretion regardless of 
      other clinical indicators was associated with the higher relative risk (RR) of 
      AKI, which increased by 2.3 times with a rise in one of these indicators and by 
      3.4 times with a rise in both indicators. CONCLUSION: Multiple renal toxic 
      effects after HSCT result in a substantial and simultaneous elevation of urinary 
      excretion of BMs for tubular damage. Among the BMs studied, KIM-1 and MCP-1 seem 
      to be the most suitable molecules for assessing the risk of AKI in this cohort of 
      patient within the predictive diagnostic approach.
FAU - Dobronravov, V A
AU  - Dobronravov VA
AD  - I.P. Pavlov First Saint Petersburg Medical University, Ministry of Health of 
      Russia, Saint Petersburg, Russia.
FAU - Smirnov, K A
AU  - Smirnov KA
AD  - I.P. Pavlov First Saint Petersburg Medical University, Ministry of Health of 
      Russia, Saint Petersburg, Russia.
FAU - Afanasiev, B V
AU  - Afanasiev BV
AD  - I.P. Pavlov First Saint Petersburg Medical University, Ministry of Health of 
      Russia, Saint Petersburg, Russia.
FAU - Galkina, O V
AU  - Galkina OV
AD  - I.P. Pavlov First Saint Petersburg Medical University, Ministry of Health of 
      Russia, Saint Petersburg, Russia.
FAU - Smirnov, A V
AU  - Smirnov AV
AD  - I.P. Pavlov First Saint Petersburg Medical University, Ministry of Health of 
      Russia, Saint Petersburg, Russia.
LA  - rus
PT  - Journal Article
PT  - Observational Study
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (HAVCR1 protein, human)
RN  - 0 (Hepatitis A Virus Cellular Receptor 1)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Virus)
SB  - IM
MH  - *Acute Kidney Injury/diagnosis/etiology/metabolism/physiopathology
MH  - Adult
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Hepatitis A Virus Cellular Receptor 1
MH  - Humans
MH  - Kidney Function Tests
MH  - *Kidney Tubules/metabolism/pathology/physiopathology
MH  - Male
MH  - Membrane Glycoproteins/*blood
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Receptors, Virus/*blood
MH  - Reproducibility of Results
MH  - Russia
EDAT- 2016/06/15 06:00
MHDA- 2016/08/25 06:00
CRDT- 2016/06/15 06:00
PHST- 2016/06/15 06:00 [entrez]
PHST- 2016/06/15 06:00 [pubmed]
PHST- 2016/08/25 06:00 [medline]
AID - 10.17116/terarkh201688614-20 [doi]
PST - ppublish
SO  - Ter Arkh. 2016;88(6):14-20. doi: 10.17116/terarkh201688614-20.