PMID- 27297423
OWN - NLM
STAT- MEDLINE
DCOM- 20170714
LR  - 20211204
IS  - 1976-555X (Electronic)
IS  - 1229-845X (Print)
IS  - 1229-845X (Linking)
VI  - 18
IP  - 1
DP  - 2017 Mar 30
TI  - Temporal changes in mammalian target of rapamycin (mTOR) and phosphorylated-mTOR 
      expressions in the hippocampal CA1 region of rat with vascular dementia.
PG  - 11-16
LID - 10.4142/jvs.2017.18.1.11 [doi]
AB  - Mammalian target of rapamycin (mTOR) has an important role in various biological 
      processes in cells. In the present study, we investigated temporal changes in 
      mTOR and phosphorylated-mTOR (p-mTOR) expressions in the rat hippocampal CA1 
      region following chronic cerebral hypoperfusion (CCH) induced by permanent 
      bilateral common carotid arteries occlusion (2VO). The mTOR immunoreactivity in 
      the pyramidal neurons and mTOR protein level in the hippocampal CA1 region were 
      markedly decreased at 21 and 28 days after 2VO surgery. However, p-mTOR protein 
      expression was significantly increased at 7 days following CCH but then decreased 
      with time. The results indicate that mTOR and p-mTOR expressions change in the 
      hippocampal CA1 region after 2VO surgery and that reduced expressions of mTOR and 
      p-mTOR may be closely related to the CCH-induced neuronal damage in the 
      hippocampal CA1 region.
FAU - Park, Jin-A
AU  - Park JA
AD  - Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, 
      Korea.
FAU - Lee, Choong-Hyun
AU  - Lee CH
AD  - Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, 
      Korea.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Vet Sci
JT  - Journal of veterinary science
JID - 100964185
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/etiology/*physiopathology
MH  - CA1 Region, Hippocampal/metabolism/*physiopathology
MH  - Dementia, Vascular/etiology/*physiopathology
MH  - *Gene Expression
MH  - Male
MH  - Phosphorylation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - TOR Serine-Threonine Kinases/*genetics/metabolism
PMC - PMC5366295
OTO - NOTNLM
OT  - chronic cerebral hypoperfusion
OT  - hippocampal CA1 region
OT  - mammals
OT  - sirolimus
OT  - vascular dementia
COIS- Conflict of Interest: The authors declare no conflicts of interest.
EDAT- 2016/06/15 06:00
MHDA- 2017/07/15 06:00
PMCR- 2017/03/01
CRDT- 2016/06/15 06:00
PHST- 2016/02/05 00:00 [received]
PHST- 2016/03/21 00:00 [revised]
PHST- 2016/05/12 00:00 [accepted]
PHST- 2016/06/15 06:00 [pubmed]
PHST- 2017/07/15 06:00 [medline]
PHST- 2016/06/15 06:00 [entrez]
PHST- 2017/03/01 00:00 [pmc-release]
AID - jvs.2016.027 [pii]
AID - 10.4142/jvs.2017.18.1.11 [doi]
PST - ppublish
SO  - J Vet Sci. 2017 Mar 30;18(1):11-16. doi: 10.4142/jvs.2017.18.1.11.