PMID- 27300327
OWN - NLM
STAT- MEDLINE
DCOM- 20170425
LR  - 20181113
IS  - 2194-1327 (Electronic)
IS  - 0948-6259 (Linking)
VI  - 30
IP  - 2
DP  - 2016 Jun
TI  - [Anchor-based ascertaining of meaningful changes in depressive symptoms using the 
      example of the German short form of the CES-D].
PG  - 82-91
LID - 10.1007/s40211-016-0184-z [doi]
AB  - BACKGROUND AND OBJECTIVES: Depression is frequently measured on the 15 item 
      version of the Center for Epidemiological Studies Depression Scale (CES-D-15). Up 
      to now, there are no data based estimates for minimal clinically important 
      differences (MCID) in depression scales. METHODS: Data on 5241 subjects with 
      depressive symptoms from a German psychosomatic hospital were used. The changes 
      in the CES-D-15 from admission to discharge were compared to the clinically 
      global impression of change (CGIC), i. e., the therapists' perception. Categories 
      of "slightly improved" and "much improved" were used as indicators of 
      a clinically important difference. The relation between these ratings and the 
      CES-D-15 was explored using mean change scores and sensitivity/specificity 
      analyses. RESULTS: On average, a reduction of approximately nine points or 
      30 percent in the CES-D-15 or an individual effect size of 0.9 represented 
      a minimal clinically important difference. A consistent relationship between the 
      changes in the CES-D-15 and the CGIC was demonstrated irrespective of age, 
      gender, education level, type of treatment, or first diagnosis. However, higher 
      baseline scores in CES-D-15 required larger changes of raw values to represent 
      a clinically important difference. CONCLUSIONS: Our results show anchor-based 
      values for change in CES-D-15 that best represent a minimal clinically important 
      difference. Reporting the percentage of patients who have reached the MCID 
      improves the evaluation of therapeutical processes. The estimated MCID could also 
      be used as an indicator for relevant changes in clinical practice. A further 
      examination in other patient populations will be needed.
FAU - Haase, Ingo
AU  - Haase I
AD  - Abt. Forschung und Qualitatssicherung, m&i-Klinikgruppe Enzensberg, Hohenstr. 56, 
      87629, Hopfen, Deutschland. ingo.haase@enzensberg.de.
FAU - Winkeler, Markus
AU  - Winkeler M
AD  - Parkland-Klinik, Im Kreuzfeld 6, 34537, Bad Wildungen, Deutschland.
FAU - Imgart, Hartmut
AU  - Imgart H
AD  - Parkland-Klinik, Im Kreuzfeld 6, 34537, Bad Wildungen, Deutschland.
LA  - ger
PT  - Journal Article
TT  - Ankerbasierte Ermittlung klinisch relevanter Veranderung depressiver Symptomatik 
      am Beispiel der Kurzform der CES-D.
DEP - 20160614
PL  - Germany
TA  - Neuropsychiatr
JT  - Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der 
      Gesellschaft Osterreichischer Nervenarzte und Psychiater
JID - 9440588
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Depressive Disorder/*diagnosis/psychology/*therapy
MH  - Female
MH  - Germany
MH  - Hospitals, Psychiatric
MH  - Humans
MH  - Length of Stay/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Patient Discharge
MH  - Personality Assessment/statistics & numerical data
MH  - Psychiatric Status Rating Scales/*statistics & numerical data
MH  - Psychometrics/*statistics & numerical data
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Depressive disorder
OT  - Minimal clinically important difference
OT  - Psychosomatic medicine
OT  - Treatment outcome
EDAT- 2016/06/15 06:00
MHDA- 2017/04/26 06:00
CRDT- 2016/06/15 06:00
PHST- 2016/02/22 00:00 [received]
PHST- 2016/05/05 00:00 [accepted]
PHST- 2016/06/15 06:00 [entrez]
PHST- 2016/06/15 06:00 [pubmed]
PHST- 2017/04/26 06:00 [medline]
AID - 10.1007/s40211-016-0184-z [pii]
AID - 10.1007/s40211-016-0184-z [doi]
PST - ppublish
SO  - Neuropsychiatr. 2016 Jun;30(2):82-91. doi: 10.1007/s40211-016-0184-z. Epub 2016 
      Jun 14.