PMID- 27300472
OWN - NLM
STAT- MEDLINE
DCOM- 20170314
LR  - 20181202
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 48
IP  - 10
DP  - 2016 Sep
TI  - Lower Circulating Irisin Level in Patients with Diabetes Mellitus: A Systematic 
      Review and Meta-Analysis.
PG  - 644-652
AB  - Studies measuring circulating irisin levels in patients with insulin resistance 
      conditions such as type 2 diabetes mellitus (T2DM) and gestational diabetes 
      mellitus (GDM) have achieved controversial results. Our systematic review and 
      meta-analysis aim to assess the circulating irisin levels in patients with 
      diabetes mellitus. Pubmed, EMBASE, CENTRAL, ISI Web of Science, and CNKI were 
      searched to identify observational studies of circulating irisin levels in 
      patients with diabetes mellitus. Two reviewers independently searched the 
      databases and screened studies according to the inclusion criteria. Data were 
      extracted using a standardized collection form. Meta-analysis was performed. A 
      total of 23 studies (17 cross-sectional and 6 case control) involving 1 745 
      diabetic patients and 1 337 non-diabetic controls were selected. Compared with 
      non-diabetic controls, circulating irisin concentrations were significantly lower 
      in patients with T2DM (SMD -1.72, 95%CI -2.49, -0.96; p<0.00001) and GDM (SMD 
      -0.76, 95CI -1.31, -0.22; p=0.006), but 30 percent higher in patients with T1DM. 
      Circulating irisin in Asian diabetic patients decreased more than European 
      patients. The findings of our current review suggest that circulating irisin 
      levels were decreased in patients with T2DM and GDM, but not in patients with 
      T1DM.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Du, X-L
AU  - Du XL
AD  - Nursing Management Department, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Jiang, W-X
AU  - Jiang WX
AD  - Department of Otorhinolaryngology, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Lv, Z-T
AU  - Lv ZT
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20160614
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Biomarkers)
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
SB  - IM
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - Diabetes Mellitus/*blood/diagnosis
MH  - Diabetes, Gestational/*blood/diagnosis
MH  - Female
MH  - Fibronectins/*blood
MH  - Humans
MH  - Pregnancy
MH  - Prognosis
EDAT- 2016/06/15 06:00
MHDA- 2017/03/16 06:00
CRDT- 2016/06/15 06:00
PHST- 2016/06/15 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
PHST- 2016/06/15 06:00 [entrez]
AID - 10.1055/s-0042-108730 [doi]
PST - ppublish
SO  - Horm Metab Res. 2016 Sep;48(10):644-652. doi: 10.1055/s-0042-108730. Epub 2016 
      Jun 14.