PMID- 27300649
OWN - NLM
STAT- MEDLINE
DCOM- 20170126
LR  - 20220409
IS  - 1826-6983 (Electronic)
IS  - 0033-8362 (Linking)
VI  - 121
IP  - 10
DP  - 2016 Oct
TI  - Three-dimensional surface imaging for detection of intra-fraction setup 
      variations during radiotherapy of pelvic tumors.
PG  - 805-10
LID - 10.1007/s11547-016-0659-9 [doi]
AB  - PURPOSE: Surface-based image guided radiotherapy (IGRT) allows positioning and/or 
      monitoring patients in 3 dimensions (3D), without the use of ionizing radiation. 
      In this study, we report on intra-fraction motion measured by acquisition of 
      multiple images of 3D body surfaces. MATERIALS AND METHODS: Twenty-nine patients 
      treated for pelvic tumors were enrolled. Setup variations (SV) through three 
      consecutive body surfaces acquired by the optical IGRT system Align-RT 
      (Vision-RT, London, UK) were analyzed before, during and at the end of treatment 
      delivery. Displacements along the main axes (X, Y and Z) from initial (I) to 
      mid-treatment (MT) and final (F) acquisitions were recorded. Time and direction 
      of SV were assessed. RESULTS: A total of 6272 images from 792 fractions of 29 
      patients were available. The main source of misalignment was between I and MT 
      acquisition (p < 0.001). The dominant SV direction was the vertical one (Z axis), 
      with mean SV of -1.20 +/- 0.06 mm and -1.55 +/- 0.06 mm for I-MT and I-F 
      acquisitions, respectively. The Y mean components of SV were, respectively, 
      -0.95 +/- 0.10 mm and -1.0 +/- 0.10 for I-MT and I-F acquisitions, while the X 
      deviations were 0.07 +/- 0.08 mm for I-MT and 0.26 +/- 0.08 mm I-F. CONCLUSION: 
      Three-D surface imaging for patient setup monitoring highlighted remarkable 
      mobility of patients during RT session, especially in the anterior-posterior 
      direction (Z axis). The largest magnitude in patient movements occurred during 
      the first part of delivery. These findings suggest that the initial setup control 
      cannot not to be sufficient to guarantee treatment reproducibility, especially 
      for long-lasting RT treatments.
FAU - Apicella, Giuseppina
AU  - Apicella G
AD  - Division of Radiotherapy, University Hospital "Maggiore della Carita", Novara, 
      Italy.
FAU - Loi, Gianfranco
AU  - Loi G
AD  - Medical Physics, University Hospital "Maggiore della Carita", Novara, Italy.
FAU - Torrente, Sara
AU  - Torrente S
AD  - Division of Radiotherapy, University Hospital "Maggiore della Carita", Novara, 
      Italy.
FAU - Crespi, Silvia
AU  - Crespi S
AD  - Division of Radiotherapy, University Hospital "Maggiore della Carita", Novara, 
      Italy.
FAU - Beldi, Debora
AU  - Beldi D
AD  - Division of Radiotherapy, University Hospital "Maggiore della Carita", Novara, 
      Italy.
FAU - Brambilla, Marco
AU  - Brambilla M
AD  - Medical Physics, University Hospital "Maggiore della Carita", Novara, Italy.
FAU - Krengli, Marco
AU  - Krengli M
AD  - Division of Radiotherapy, University Hospital "Maggiore della Carita", Novara, 
      Italy. krengli@med.unipmn.it.
AD  - Department of Translational Medicine, University of "Piemonte Orientale", Novara, 
      Italy. krengli@med.unipmn.it.
LA  - eng
PT  - Journal Article
DEP - 20160614
PL  - Italy
TA  - Radiol Med
JT  - La Radiologia medica
JID - 0177625
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Genital Neoplasms, Female/*radiotherapy
MH  - Genital Neoplasms, Male/*radiotherapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Positioning
MH  - Quality Assurance, Health Care
MH  - Radiotherapy Setup Errors/*prevention & control
MH  - Radiotherapy, Image-Guided/*methods
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - IGRT
OT  - Intra-fraction
OT  - Organ motion
OT  - Radiotherapy
OT  - Setup
OT  - Surface imaging
EDAT- 2016/06/15 06:00
MHDA- 2017/01/27 06:00
CRDT- 2016/06/15 06:00
PHST- 2016/02/23 00:00 [received]
PHST- 2016/05/30 00:00 [accepted]
PHST- 2016/06/15 06:00 [entrez]
PHST- 2016/06/15 06:00 [pubmed]
PHST- 2017/01/27 06:00 [medline]
AID - 10.1007/s11547-016-0659-9 [pii]
AID - 10.1007/s11547-016-0659-9 [doi]
PST - ppublish
SO  - Radiol Med. 2016 Oct;121(10):805-10. doi: 10.1007/s11547-016-0659-9. Epub 2016 
      Jun 14.