PMID- 27301371 OWN - NLM STAT- MEDLINE DCOM- 20170713 LR - 20220316 IS - 1527-330X (Electronic) IS - 1090-820X (Print) IS - 1090-820X (Linking) VI - 36 IP - 7 DP - 2016 Jul TI - Efficacy and Safety of a Hyaluronic Acid Filler to Correct Aesthetically Detracting or Deficient Features of the Asian Nose: A Prospective, Open-Label, Long-Term Study. PG - 760-72 LID - 10.1093/asj/sjw079 [doi] AB - BACKGROUND: There is increasing interest among patients and plastic surgeons for alternatives to rhinoplasty, a common surgical procedure performed in Asia. OBJECTIVES: To evaluate the safety, efficacy, and longevity of a hyaluronic acid filler in the correction of aesthetically detracting or deficient features of the Asian nose. METHODS: Twenty-nine carefully screened Asian patients had their noses corrected with the study filler (Juvederm VOLUMA [Allergan plc, Dublin, Ireland] with lidocaine injectable gel), reflecting individualized treatment goals and utilizing a standardized injection procedure, and were followed for over 12 months. RESULTS: A clinically meaningful correction (>/=1 grade improvement on the Assessment of Aesthetic Improvement Scale) was achieved in 27 (93.1%) patients at the first follow-up visit. This was maintained in 28 (96.6%) patients at the final visit, based on the independent assessments of a central non-injecting physician and the patients. At this final visit, 23 (79.3%) patients were satisfied or very satisfied with the study filler and 25 (86.2%) would recommend it to others. In this small series of patients, there were no serious adverse events (AEs), with all treatment-related AEs being mild to moderate, transient injection site reactions, unrelated to the study filler. CONCLUSIONS: Using specific eligibility criteria, individualized treatment goals, and a standardized injection procedure, the study filler corrected aesthetically detracting or deficient features of the Asian nose, with the therapeutic effects lasting for over 12 months, consistent with a high degree of patient satisfaction. This study supports the safety and efficacy of this HA filler for specific nose augmentation procedures in selected Asian patients. LEVEL OF EVIDENCE 3: Therapeutic. CI - (c) 2016 The American Society for Aesthetic Plastic Surgery, Inc. FAU - Liew, Steven AU - Liew S AD - Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in Sao Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore. FAU - Scamp, Terrence AU - Scamp T AD - Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in Sao Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore. FAU - de Maio, Mauricio AU - de Maio M AD - Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in Sao Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore. FAU - Halstead, Michael AU - Halstead M AD - Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in Sao Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore. FAU - Johnston, Nicole AU - Johnston N AD - Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in Sao Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore. FAU - Silberberg, Michael AU - Silberberg M AD - Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in Sao Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore. FAU - Rogers, John D AU - Rogers JD AD - Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in Sao Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore. LA - eng PT - Journal Article DEP - 20160614 PL - England TA - Aesthet Surg J JT - Aesthetic surgery journal JID - 9707469 RN - 0 (Dermatologic Agents) RN - 0 (Juvederm) RN - 9004-61-9 (Hyaluronic Acid) SB - IM MH - Adult MH - Asia MH - *Cosmetic Techniques MH - Dermatologic Agents/administration & dosage MH - Esthetics MH - Female MH - Follow-Up Studies MH - Humans MH - Hyaluronic Acid/administration & dosage/*analogs & derivatives MH - Male MH - Middle Aged MH - *Nose MH - Patient Satisfaction/*statistics & numerical data MH - Prospective Studies MH - Treatment Outcome MH - Young Adult PMC - PMC4911905 EDAT- 2016/06/16 06:00 MHDA- 2017/07/14 06:00 PMCR- 2016/06/15 CRDT- 2016/06/16 06:00 PHST- 2016/03/29 00:00 [accepted] PHST- 2016/06/16 06:00 [entrez] PHST- 2016/06/16 06:00 [pubmed] PHST- 2017/07/14 06:00 [medline] PHST- 2016/06/15 00:00 [pmc-release] AID - sjw079 [pii] AID - 10.1093/asj/sjw079 [doi] PST - ppublish SO - Aesthet Surg J. 2016 Jul;36(7):760-72. doi: 10.1093/asj/sjw079. Epub 2016 Jun 14.