PMID- 27311954
OWN - NLM
STAT- MEDLINE
DCOM- 20180118
LR  - 20191210
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 408
IP  - 21
DP  - 2016 Aug
TI  - Multiplug filtration cleanup method with multi-walled carbon nanotubes for the 
      analysis of malachite green, diethylstilbestrol residues, and their metabolites 
      in aquatic products by liquid chromatography-tandem mass spectrometry.
PG  - 5801-5809
LID - 10.1007/s00216-016-9686-6 [doi]
AB  - The food safety supervision in aquatic products has raised public concern in 
      recent years. In this study, a liquid chromatographic-tandem mass spectrometric 
      (LC-MS/MS) method for the simultaneous quantification and identification of four 
      residues of the ever widely used analytes (including malachite green, 
      leucomalachite green, diethylstilbestrol, and dienestrol) in aquaculture samples 
      was developed. For sample preparation, a modified QuEChERS (quick, easy, cheap, 
      effective, rugged, and safe) method was used, which was initially developed for 
      pesticide residue analysis. For cleanup procedure, low-temperature cleanup method 
      was combined with multiplug filtration cleanup (m-PFC) method based on 
      multi-walled carbon nanotubes (MWCNTs). The volume of water, extraction solvent, 
      cleanup sorbents, and m-PFC procedure were optimized for carp, striped bass, and 
      giant salamander matrices. It was validated by analyzing four residues in each 
      matrix spiked at three concentration levels of 0.5, 5, and 50 mug/kg (n = 5). The 
      method was successfully validated according to the 2002/657/EC guidelines. After 
      optimization, spike recoveries were within 73-106 % and <15 % relative standard 
      deviations (RSDs) for all analytes in the tested matrices. Limits of 
      quantification (LOQs) for the proposed method ranged from 0.10 to 0.50 mug/kg. 
      Matrix-matched calibrations were performed with the coefficients of determination 
      >0.998 between concentration levels of 0.5 and 200 mug/kg. The developed method 
      was successfully applied to the determination of residues in market samples. 
      Graphical abstract Flow chart of multi-plug filtration cleanup combined with 
      low-temperature cleanup method.
FAU - Qin, Yuhong
AU  - Qin Y
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, College of Science, China Agricultural 
      University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China.
FAU - Zhang, Jingru
AU  - Zhang J
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, College of Science, China Agricultural 
      University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China.
FAU - Li, Yanjie
AU  - Li Y
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, College of Science, China Agricultural 
      University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China.
FAU - Han, Yongtao
AU  - Han Y
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, College of Science, China Agricultural 
      University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China.
FAU - Zou, Nan
AU  - Zou N
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, College of Science, China Agricultural 
      University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China.
FAU - Jiang, Yanbin
AU  - Jiang Y
AD  - China Animal Disease Control Center (CADC), Maizidian Street Building 20, 
      Beijing, 100125, China.
FAU - Shan, Jihao
AU  - Shan J
AD  - Institute of Agro-Products Processing Science & Technology, Chinese Academy of 
      Agricultural Sciences (CAAS), No. 2 Yuanmingyuan West Road, Haidian District, 
      Beijing, 100193, China.
FAU - Pan, Canping
AU  - Pan C
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, College of Science, China Agricultural 
      University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China. 
      canpingp@cau.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20160616
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (Rosaniline Dyes)
RN  - 12058M7ORO (malachite green)
RN  - 731DCA35BT (Diethylstilbestrol)
RN  - 8U61G37Z20 (leucomalachite green)
RN  - RRW32X4U1F (Dienestrol)
SB  - IM
MH  - Animals
MH  - Bass/metabolism
MH  - Carps/metabolism
MH  - Chromatography, Liquid/methods
MH  - Dienestrol/analysis/metabolism
MH  - Diethylstilbestrol/*analysis/metabolism
MH  - Drug Residues/*analysis/metabolism
MH  - Food Contamination/*analysis
MH  - Limit of Detection
MH  - Nanotubes, Carbon/*chemistry
MH  - Rosaniline Dyes/*analysis/metabolism
MH  - Seafood/*analysis
MH  - Solid Phase Extraction/methods
MH  - Tandem Mass Spectrometry/*methods
MH  - Urodela/metabolism
OTO - NOTNLM
OT  - Aquaculture
OT  - Multiple-walled carbon nanotubes
OT  - Multiplug filtration cleanup
OT  - Residue analysis
EDAT- 2016/06/18 06:00
MHDA- 2018/01/19 06:00
CRDT- 2016/06/18 06:00
PHST- 2016/05/02 00:00 [received]
PHST- 2016/06/02 00:00 [accepted]
PHST- 2016/05/22 00:00 [revised]
PHST- 2016/06/18 06:00 [entrez]
PHST- 2016/06/18 06:00 [pubmed]
PHST- 2018/01/19 06:00 [medline]
AID - 10.1007/s00216-016-9686-6 [pii]
AID - 10.1007/s00216-016-9686-6 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2016 Aug;408(21):5801-5809. doi: 10.1007/s00216-016-9686-6. 
      Epub 2016 Jun 16.