PMID- 27312089
OWN - NLM
STAT- MEDLINE
DCOM- 20180222
LR  - 20180222
IS  - 1445-2197 (Electronic)
IS  - 1445-1433 (Linking)
VI  - 87
IP  - 7-8
DP  - 2017 Jul
TI  - Expression of CUL1 correlates with tumour-grade and recurrence in urothelial 
      carcinoma.
PG  - 624-629
LID - 10.1111/ans.13438 [doi]
AB  - BACKGROUND: Urothelial carcinoma (UC) is a major health problem in the general 
      population. We aimed to evaluate the function of Cullin-1 (CUL1) and unravel its 
      underlying molecular mechanism to develop novel treatment options equivalent to 
      UC. METHODS: To evaluate the function of CUL1, a group of 132 pairs of UC 
      patients were recruited for this study. UC tissues and their adjacent 
      noncancerous tissues (NCTs) were collected between 2008 and 2009. We used 
      immunohistochemistry to analyse the correlation between CUL1 expression and 
      clinicopathologic variables and patient survival. RESULTS: CUL1 was dramatically 
      overexpressed in high-grade UC tissues compared with low-grade UC tissues. CUL1 
      up-regulation in recurrence cases in comparison with the non-recurrence cases. 
      CUL1 expression upregulated in human UC tissues versus NCTs. CUL1 protein 
      expression associated with androgen receptor. CONCLUSIONS: Our results 
      demonstrate that increased CUL1 expression is significantly correlated with poor 
      prognosis of patients with UC. CUL1 might be an important marker and a 
      therapeutic target for UC.
CI  - (c) 2016 Royal Australasian College of Surgeons.
FAU - Mao, Shi-Yu
AU  - Mao SY
AD  - Department of Urology, Shanghai Tenth People's Hospital, Tongji University, 
      Shanghai, China.
FAU - Xiong, Da-Bo
AU  - Xiong DB
AD  - Department of Urology, Shanghai Tenth People's Hospital, Tongji University, 
      Shanghai, China.
FAU - Huang, Tian-Bao
AU  - Huang TB
AD  - Department of Urology, Shanghai Tenth People's Hospital, Tongji University, 
      Shanghai, China.
FAU - Zheng, Jun-Hua
AU  - Zheng JH
AD  - Department of Urology, Shanghai Tenth People's Hospital, Tongji University, 
      Shanghai, China.
FAU - Yao, Xu-Dong
AU  - Yao XD
AD  - Department of Urology, Shanghai Tenth People's Hospital, Tongji University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20160616
PL  - Australia
TA  - ANZ J Surg
JT  - ANZ journal of surgery
JID - 101086634
RN  - 0 (Cullin 1)
RN  - 0 (Cullin Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Transitional Cell/*genetics/*pathology
MH  - Cullin Proteins/*genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Urinary Bladder Neoplasms/*genetics/*pathology
OTO - NOTNLM
OT  - CUL1
OT  - recurrence
OT  - tumour grade
OT  - urothelial carcinoma
EDAT- 2016/06/18 06:00
MHDA- 2018/02/23 06:00
CRDT- 2016/06/18 06:00
PHST- 2015/12/02 00:00 [accepted]
PHST- 2016/06/18 06:00 [pubmed]
PHST- 2018/02/23 06:00 [medline]
PHST- 2016/06/18 06:00 [entrez]
AID - 10.1111/ans.13438 [doi]
PST - ppublish
SO  - ANZ J Surg. 2017 Jul;87(7-8):624-629. doi: 10.1111/ans.13438. Epub 2016 Jun 16.