PMID- 27312327
OWN - NLM
STAT- MEDLINE
DCOM- 20170221
LR  - 20181113
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 105
IP  - 11
DP  - 2016 Nov
TI  - Obstructive sleep apnea might trigger acute pulmonary embolism: results from a 
      cohort study.
PG  - 938-943
AB  - BACKGROUND: Obstructive sleep apnea (OSA) might be an independent risk factor for 
      acute pulmonary embolism (APE). AIM OF THE STUDY: A prospective cohort study was 
      conducted to investigate if APE is sleep-related in untreated OSA syndrome or 
      not. METHODS: 206 APE patients were evaluated by portable monitoring and 
      polysomnography. APE symptoms which caused an arousal from sleep or occurred 
      within the first hour after wake-up were considered to be sleep-related. RESULTS: 
      APE manifestation is significantly more often sleep-related in patients with 
      moderate or severe OSA compared to subjects with an apnea-hypopnea index </=15/h 
      (p < 0.001). The relative risk of sleep-related APE increases with the severity 
      of OSA. CONCLUSIONS: OSA might trigger APE, possibly reflecting a 
      pathophysiological relationship between these two conditions.
FAU - Berghaus, T M
AU  - Berghaus TM
AD  - Department of Cardiology, Respiratory Medicine and Intensive Care, Klinikum 
      Augsburg, Ludwig-Maximilians University Munich, Stenglinstrasse 2, 86156, 
      Augsburg, Germany. thomas.berghaus@klinikum-augsburg.de.
FAU - Witkowska, A
AU  - Witkowska A
AD  - Department of Cardiology, Respiratory Medicine and Intensive Care, Klinikum 
      Augsburg, Ludwig-Maximilians University Munich, Stenglinstrasse 2, 86156, 
      Augsburg, Germany.
FAU - Wagner, T
AU  - Wagner T
AD  - Department of Cardiology, Respiratory Medicine and Intensive Care, Klinikum 
      Augsburg, Ludwig-Maximilians University Munich, Stenglinstrasse 2, 86156, 
      Augsburg, Germany.
FAU - Faul, C
AU  - Faul C
AD  - Department of Cardiology, Respiratory Medicine and Intensive Care, Klinikum 
      Augsburg, Ludwig-Maximilians University Munich, Stenglinstrasse 2, 86156, 
      Augsburg, Germany.
FAU - Schwaiblmair, M
AU  - Schwaiblmair M
AD  - Department of Cardiology, Respiratory Medicine and Intensive Care, Klinikum 
      Augsburg, Ludwig-Maximilians University Munich, Stenglinstrasse 2, 86156, 
      Augsburg, Germany.
FAU - von Scheidt, W
AU  - von Scheidt W
AD  - Department of Cardiology, Respiratory Medicine and Intensive Care, Klinikum 
      Augsburg, Ludwig-Maximilians University Munich, Stenglinstrasse 2, 86156, 
      Augsburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20160616
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polysomnography
MH  - Prospective Studies
MH  - Pulmonary Embolism/diagnosis/*etiology
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sleep Apnea, Obstructive/*complications/diagnosis
OTO - NOTNLM
OT  - Day-night pattern
OT  - Pulmonary embolism
OT  - Sleep-disordered breathing
OT  - Symptom onset
EDAT- 2016/10/23 06:00
MHDA- 2017/02/22 06:00
CRDT- 2016/06/18 06:00
PHST- 2016/03/10 00:00 [received]
PHST- 2016/05/27 00:00 [accepted]
PHST- 2016/10/23 06:00 [pubmed]
PHST- 2017/02/22 06:00 [medline]
PHST- 2016/06/18 06:00 [entrez]
AID - 10.1007/s00392-016-1002-0 [pii]
AID - 10.1007/s00392-016-1002-0 [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2016 Nov;105(11):938-943. doi: 10.1007/s00392-016-1002-0. Epub 
      2016 Jun 16.