PMID- 27313402
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20221207
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2016
DP  - 2016
TI  - Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 
      Diabetes and Are Positively Correlated with Glucose and Lipid Parameters.
PG  - 6423637
LID - 10.1155/2016/6423637 [doi]
LID - 6423637
AB  - The purpose of this study is to examine the relations among plasma periostin, 
      glucose and lipid metabolism, insulin resistance and inflammation in Chinese 
      patients with obesity (OB), and type 2 diabetes mellitus (T2DM). Plasma periostin 
      levels in the T2DM group were significantly higher than the NGT group (P < 0.01). 
      Patients with both OB and T2DM had the highest periostin levels. Correlation 
      analysis showed that plasma periostin levels were positively correlated with 
      weight, waist circumference (WC), body mass index (BMI), waist-hip ratio (WHR), 
      fasting plasma glucose (FPG), 2 h postchallenge plasma glucose (2 h PG), glycated 
      hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), fasting insulin 
      (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), TNF-alpha, and 
      IL-6 (P < 0.05 or 0.001) and negatively correlated with high-density lipoprotein 
      cholesterol (HDL-C) (P < 0.001). Multiple linear regression analysis showed that 
      TG, TNF-alpha, and HOMA-IR were independent related factors in influencing the levels 
      of plasma periostin (P < 0.001). These results suggested that Chinese patients 
      with obesity and T2DM had significantly higher plasma periostin levels. Plasma 
      periostin levels were strongly associated with plasma TG, chronic inflammation, 
      and insulin resistance.
FAU - Luo, Yuanyuan
AU  - Luo Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Qu, Hua
AU  - Qu H
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Wang, Hang
AU  - Wang H
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Wei, Huili
AU  - Wei H
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Wu, Jing
AU  - Wu J
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Duan, Yang
AU  - Duan Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Liu, Dan
AU  - Liu D
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Deng, Huacong
AU  - Deng H
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
LA  - eng
PT  - Journal Article
DEP - 20160522
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Blood Glucose)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (POSTN protein, human)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Body Weight/physiology
MH  - Cell Adhesion Molecules/*blood
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Fasting/blood
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood
MH  - Triglycerides/blood
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Waist Circumference/physiology
MH  - Waist-Hip Ratio
PMC - PMC4893582
EDAT- 2016/06/18 06:00
MHDA- 2017/05/16 06:00
PMCR- 2016/05/22
CRDT- 2016/06/18 06:00
PHST- 2015/12/31 00:00 [received]
PHST- 2016/04/07 00:00 [revised]
PHST- 2016/05/05 00:00 [accepted]
PHST- 2016/06/18 06:00 [entrez]
PHST- 2016/06/18 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
PHST- 2016/05/22 00:00 [pmc-release]
AID - 10.1155/2016/6423637 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2016;2016:6423637. doi: 10.1155/2016/6423637. Epub 2016 May 
      22.