PMID- 27313757
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 11
IP  - 6
DP  - 2016 Jun
TI  - T cell receptor rearrangements in a patient with gamma-heavy chain disease: A case 
      report.
PG  - 4147-4151
AB  - Heavy chain diseases (HCDs) are rare B cell lymphoplasma cell proliferative 
      disorders that are characterized by the production of incomplete monoclonal 
      immunoglobulin (Ig) heavy chains without the associated light chains. gamma-HCD (IgG 
      subtype) is a rare subtype, with ~150 cases reported in the literature to date; 
      however, to the best of our knowledge, no reports of T cell receptor (TCR) gene 
      rearrangement in gamma-HCD exist in the literature. The present study reports the 
      case of an 81-year-old man with gamma-heavy chain disease associated with TCR gene 
      rearrangement, identified in lymph node biopsy and bone marrow aspirate 
      specimens. The present case revealed an alternative manifestation of gamma-HCD, which 
      may provide additional biological insights into this rare B cell disorder.
FAU - Zhou, Hebing
AU  - Zhou H
AD  - Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 
      101149, P.R. China.
FAU - Chen, Wenming
AU  - Chen W
AD  - Department of Hematology, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing 100021, P.R. China.
FAU - Zhang, Juan
AU  - Zhang J
AD  - Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 
      101149, P.R. China.
FAU - Zeng, Hui
AU  - Zeng H
AD  - Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 
      101149, P.R. China.
FAU - Jian, Yuan
AU  - Jian Y
AD  - Department of Hematology, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing 100021, P.R. China.
FAU - Fu, Chenxiao
AU  - Fu C
AD  - Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 
      101149, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20160504
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC4888291
OTO - NOTNLM
OT  - B cell neoplasm
OT  - T cell receptor rearrangement
OT  - gamma-heavy chain disease
EDAT- 2016/06/18 06:00
MHDA- 2016/06/18 06:01
PMCR- 2016/05/04
CRDT- 2016/06/18 06:00
PHST- 2015/02/05 00:00 [received]
PHST- 2016/03/15 00:00 [accepted]
PHST- 2016/06/18 06:00 [entrez]
PHST- 2016/06/18 06:00 [pubmed]
PHST- 2016/06/18 06:01 [medline]
PHST- 2016/05/04 00:00 [pmc-release]
AID - OL-0-0-4515 [pii]
AID - 10.3892/ol.2016.4515 [doi]
PST - ppublish
SO  - Oncol Lett. 2016 Jun;11(6):4147-4151. doi: 10.3892/ol.2016.4515. Epub 2016 May 4.