PMID- 27314341
OWN - NLM
STAT- MEDLINE
DCOM- 20170321
LR  - 20181202
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 17
IP  - 6
DP  - 2016 Jun 15
TI  - The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal 
      Constituent Cells in Solar Lentigo.
LID - 10.3390/ijms17060948 [doi]
LID - 948
AB  - Solar lentigo (SL) is a representative photoaging skin disorder. Alteration of 
      the main epidermal constituent cells-keratinocytes and melanocytes-in relation to 
      the photoaged dermal environment or chemokine/cytokine network is suggested as 
      its pathogenesis. Among these, we focused on monocyte chemoattractant protein-1 
      (MCP-1), as it is known to be associated with tissue aging. For the first time, 
      we report that the MCP-1 receptor, CCR2, is expressed in normal human 
      melanocytes. In SL tissue, there was an increase of CCR2+Melan A+ melanocytes 
      with positivity to Rb protein compared to peri-lesional normal skin. MCP-1 
      induced the proliferation of normal human melanocytes without a significant 
      change in the melanin content. MCP-1 treatment in normal human keratinocytes 
      showed an increase in senescence-associated beta-galactosidase staining and p53 and 
      p21 protein expressions. In summary, MCP-1 may participate in the development of 
      SL by affecting epidermal constituent cells, for example, by inducing melanocyte 
      proliferation and keratinocyte senescence.
FAU - Lee, Woo Jin
AU  - Lee WJ
AD  - Department of Dermatology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul 138-736, Korea. uucm79@hanmail.net.
FAU - Jo, Soo Youn
AU  - Jo SY
AD  - Department of Dermatology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul 138-736, Korea. sooyounyda@gmail.com.
FAU - Lee, Mi Hye
AU  - Lee MH
AD  - Department of Dermatology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul 138-736, Korea. algp_@naver.com.
FAU - Won, Chong Hyun
AU  - Won CH
AD  - Department of Dermatology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul 138-736, Korea. chwon98@chol.com.
FAU - Lee, Mi Woo
AU  - Lee MW
AD  - Department of Dermatology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul 138-736, Korea. miumiu@amc.seoul.kr.
FAU - Choi, Jee Ho
AU  - Choi JH
AD  - Department of Dermatology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul 138-736, Korea. jhchoy@amc.seoul.kr.
FAU - Chang, Sung Eun
AU  - Chang SE
AD  - Department of Dermatology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul 138-736, Korea. csesnumd@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20160615
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - EC 3.2.1.23 (beta-Galactosidase)
SB  - IM
MH  - Aged
MH  - Biomarkers
MH  - Biopsy
MH  - Cell Proliferation/radiation effects
MH  - Cell Survival/genetics/radiation effects
MH  - Cellular Senescence/genetics/radiation effects
MH  - Chemokine CCL2/genetics/metabolism/pharmacology
MH  - *Epidermal Cells
MH  - Epidermis/drug effects/*metabolism/radiation effects
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Immunohistochemistry
MH  - Keratinocytes/metabolism/pathology/radiation effects
MH  - Lentigo/drug therapy/*etiology/*metabolism/pathology
MH  - Melanocytes/metabolism/pathology/radiation effects
MH  - Middle Aged
MH  - Sunlight/*adverse effects
MH  - beta-Galactosidase/metabolism
PMC - PMC4926481
OTO - NOTNLM
OT  - epidermal constituent cells
OT  - monocyte chemoattractant protein-1
OT  - solar lentigo
EDAT- 2016/06/18 06:00
MHDA- 2017/03/23 06:00
PMCR- 2016/06/01
CRDT- 2016/06/18 06:00
PHST- 2016/04/01 00:00 [received]
PHST- 2016/06/07 00:00 [revised]
PHST- 2016/06/08 00:00 [accepted]
PHST- 2016/06/18 06:00 [entrez]
PHST- 2016/06/18 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - ijms17060948 [pii]
AID - ijms-17-00948 [pii]
AID - 10.3390/ijms17060948 [doi]
PST - epublish
SO  - Int J Mol Sci. 2016 Jun 15;17(6):948. doi: 10.3390/ijms17060948.