PMID- 27314388
OWN - NLM
STAT- MEDLINE
DCOM- 20170309
LR  - 20181113
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 8
IP  - 6
DP  - 2016 Jun 15
TI  - Caloric Restriction as a Strategy to Improve Vascular Dysfunction in Metabolic 
      Disorders.
LID - 10.3390/nu8060370 [doi]
LID - 370
AB  - Caloric restriction (CR) has proved to be the most effective and reproducible 
      dietary intervention to increase healthy lifespan and aging. A reduction in 
      cardiovascular disease (CVD) risk in obese subjects can be already achieved by a 
      moderate and sustainable weight loss. Since pharmacological approaches for body 
      weight reduction have, at present, a poor long-term efficacy, CR is of great 
      interest in the prevention and/or reduction of CVD associated with obesity. Other 
      dietary strategies changing specific macronutrients, such as altering 
      carbohydrates, protein content or diet glycemic index have been also shown to 
      decrease the progression of CVD in obese patients. In this review, we will focus 
      on the positive effects and possible mechanisms of action of these strategies on 
      vascular dysfunction.
FAU - Garcia-Prieto, Concha F
AU  - Garcia-Prieto CF
AD  - The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska 
      Institutet, Stockholm 17176, Sweden. concepcion.fernandez.garcia-prieto@ki.se.
FAU - Fernandez-Alfonso, Maria S
AU  - Fernandez-Alfonso MS
AD  - Instituto Pluridisciplinar and Facultad de Farmacia, Universidad Complutense, 
      Madrid 28040, Spain. marisolf@farm.ucm.es.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160615
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Body Weight
MH  - *Caloric Restriction
MH  - Cardiovascular Diseases/etiology/*prevention & control
MH  - Diet, Reducing
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Proteins/administration & dosage
MH  - Disease Models, Animal
MH  - Energy Intake
MH  - Glycemic Index
MH  - Humans
MH  - Metabolic Diseases/etiology/*prevention & control
MH  - Obesity/complications/diet therapy
MH  - Risk Factors
PMC - PMC4924211
OTO - NOTNLM
OT  - caloric restriction
OT  - cardiovascular disease
OT  - dietary intervention
OT  - endothelial dysfunction
OT  - obesity
EDAT- 2016/06/18 06:00
MHDA- 2017/03/10 06:00
PMCR- 2016/06/01
CRDT- 2016/06/18 06:00
PHST- 2016/03/13 00:00 [received]
PHST- 2016/05/23 00:00 [revised]
PHST- 2016/06/09 00:00 [accepted]
PHST- 2016/06/18 06:00 [entrez]
PHST- 2016/06/18 06:00 [pubmed]
PHST- 2017/03/10 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - nu8060370 [pii]
AID - nutrients-08-00370 [pii]
AID - 10.3390/nu8060370 [doi]
PST - epublish
SO  - Nutrients. 2016 Jun 15;8(6):370. doi: 10.3390/nu8060370.