PMID- 27314638
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160618
LR  - 20201001
IS  - 2372-3556 (Print)
IS  - 2372-3556 (Electronic)
IS  - 2372-3556 (Linking)
VI  - 3
IP  - 3
DP  - 2016 May
TI  - Cooperation between somatic mutations and germline susceptibility variants in 
      tumorigenesis - a dangerous liaison.
PG  - e1086853
LID - 10.1080/23723556.2015.1086853 [doi]
LID - e1086853
AB  - High-throughput genotyping and sequencing generate comprehensive catalogs of 
      inherited genetic variations and acquired somatic mutations. However, their 
      possible interactions and roles in tumorigenesis remain largely unexplored. We 
      recently reported cooperation between the EWSR1-FLI1 (Ewing sarcoma breakpoint 
      region 1 - Friend leukemia virus integration 1) fusion oncogene and a germline 
      variant that regulates the EGR2 (early growth response 2) Ewing sarcoma 
      susceptibility gene via a GGAA-microsatellite.
FAU - Grunewald, Thomas G P
AU  - Grunewald TG
AD  - Laboratory for Pediatric Sarcoma Biology, Institute of Pathology of the LMU 
      Munich, Munich, Germany; Institut Curie, PSL Research University, "Genetics and 
      Biology of Cancers" unit, Paris, France; INSERM U830, Institut Curie Research 
      Center, Paris, France.
FAU - Delattre, Olivier
AU  - Delattre O
AD  - Institut Curie, PSL Research University, "Genetics and Biology of Cancers" unit, 
      Paris, France; INSERM U830, Institut Curie Research Center, Paris, France; Unite 
      Genetique Somatique (UGS), Institut Curie Centre Hospitalier, Paris, France.
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20151006
PL  - United States
TA  - Mol Cell Oncol
JT  - Molecular & cellular oncology
JID - 101642411
CON - Nat Genet. 2015 Sep;47(9):1073-8. PMID: 26214589
PMC - PMC4909413
OTO - NOTNLM
OT  - EGR2
OT  - EWSR1-FLI1
OT  - Ewing sarcoma
OT  - GGAA-microsatellite
OT  - germline susceptibility
EDAT- 2016/06/18 06:00
MHDA- 2016/06/18 06:01
PMCR- 2016/10/06
CRDT- 2016/06/18 06:00
PHST- 2015/08/20 00:00 [received]
PHST- 2015/08/21 00:00 [revised]
PHST- 2015/08/21 00:00 [accepted]
PHST- 2016/06/18 06:00 [entrez]
PHST- 2016/06/18 06:00 [pubmed]
PHST- 2016/06/18 06:01 [medline]
PHST- 2016/10/06 00:00 [pmc-release]
AID - 1086853 [pii]
AID - 10.1080/23723556.2015.1086853 [doi]
PST - epublish
SO  - Mol Cell Oncol. 2015 Oct 6;3(3):e1086853. doi: 10.1080/23723556.2015.1086853. 
      eCollection 2016 May.