PMID- 27315207
OWN - NLM
STAT- MEDLINE
DCOM- 20170502
LR  - 20220801
IS  - 1573-7438 (Electronic)
IS  - 0049-4747 (Linking)
VI  - 48
IP  - 7
DP  - 2016 Oct
TI  - Efficacy of Fostera(R) PRRS modified live virus (MLV) vaccination strategy against 
      a Thai highly pathogenic porcine reproductive and respiratory syndrome virus 
      (HP-PRRSV) infection.
PG  - 1351-9
LID - 10.1007/s11250-016-1099-1 [doi]
AB  - Recently, the Chinese highly pathogenic porcine reproductive and respiratory 
      syndrome virus (PRRSV) (HP-PRRSV) belonging to lineage 8 causes severe symptom 
      with high morbidity and high mortality rates to the Asian pig industry. A recent 
      study showed that pigs immunized with Fostera(R) PRRS modified live virus (MLV) of 
      lineage 8 could provide a degree of protection against a Vietnamese HP-PRRSV 
      infection. It should be noted that PRRSV commonly found after weaning causes 
      porcine respiratory disease complex (PRDC). Vaccination strategy should be 
      evaluated in each farm scenario. Eighty-one PRRSV-free piglets obtained from a 
      PRRS-free herd were divided into two experiments with the major difference of 
      infection timing after vaccination, 42 days in experiment 1 (n = 42) and 28 days 
      in experiment 2 (n = 39). Each experiment had similar protocol containing three 
      groups including a negative control, unvaccinated challenged, and vaccinated 
      challenged groups. Pigs in vaccination groups were immunized with Fostera(R) PRRS 
      MLV vaccine at 3 weeks of age. Then, unvaccinated challenged and vaccinated 
      challenged groups were intranasally inoculated with a Thai HP-PRRSV (10PL01). 
      Vaccinated challenged pigs showed significantly lower levels of mean rectal 
      temperatures, clinical severity, lung lesion scores, and viral titers in serum 
      and lung tissue compared to the unvaccinated challenged pigs (p < 0.05). 
      Vaccinated challenged pigs had higher survival rate than those of unvaccinated 
      challenged pigs in both experiments. It should be noted that pigs challenged 
      42 days after vaccination showed a better performance than pigs challenged 
      28 days after vaccination. In conclusion, Fostera(R) PRRS MLV vaccine was able to 
      improve the survival rate against the Thai HP-PRRSV infection in both 42- and 
      28-day vaccination-to-infection protocols.
FAU - Charoenchanikran, Ponlakrit
AU  - Charoenchanikran P
AD  - Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, 
      Bangkok, 10330, Thailand.
FAU - Kedkovid, Roongtham
AU  - Kedkovid R
AD  - Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, 
      Bangkok, 10330, Thailand.
FAU - Sirisereewan, Chaitawat
AU  - Sirisereewan C
AD  - Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, 
      Bangkok, 10330, Thailand.
FAU - Woonwong, Yonlayong
AU  - Woonwong Y
AD  - Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, 
      Bangkok, 10330, Thailand.
FAU - Arunorat, Jirapat
AU  - Arunorat J
AD  - Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, 
      Bangkok, 10330, Thailand.
FAU - Sitthichareonchai, Panchan
AU  - Sitthichareonchai P
AD  - Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, 
      Bangkok, 10330, Thailand.
FAU - Sopipan, Natthawan
AU  - Sopipan N
AD  - Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, 
      Bangkok, 10330, Thailand.
FAU - Jittimanee, Suphattra
AU  - Jittimanee S
AD  - Department of Pathobiology, Faculty of Veterinary Medicine, Khonkhaen University, 
      Bangkok, 40002, Thailand.
FAU - Kesdangsakonwut, Sawang
AU  - Kesdangsakonwut S
AD  - Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, 
      Bangkok, 10330, Thailand. sawang.k@chula.ac.th.
FAU - Thanawongnuwech, Roongroje
AU  - Thanawongnuwech R
AD  - Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, 
      Bangkok, 10330, Thailand. roongroje.t@chula.ac.th.
AD  - Center of Emerging and Re-emerging Infectious Diseases in Animals, Faculty of 
      Veterinary Science, Chulalongkorn University, Henri-Dunant Rd., Bangkok, 10330, 
      Thailand. roongroje.t@chula.ac.th.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160617
PL  - United States
TA  - Trop Anim Health Prod
JT  - Tropical animal health and production
JID - 1277355
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antibodies, Viral/blood
MH  - Male
MH  - Porcine Reproductive and Respiratory Syndrome/mortality/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology/pathogenicity
MH  - Survival Analysis
MH  - Swine
MH  - Thailand
MH  - Tropical Climate
MH  - Vaccination/*veterinary
MH  - Vaccines, Attenuated/immunology
MH  - Viral Vaccines/*immunology
OTO - NOTNLM
OT  - Efficacy
OT  - HP-PRRSV
OT  - Lineage 8
OT  - MLV
OT  - Vaccine
EDAT- 2016/06/18 06:00
MHDA- 2017/05/04 06:00
CRDT- 2016/06/18 06:00
PHST- 2016/02/23 00:00 [received]
PHST- 2016/06/08 00:00 [accepted]
PHST- 2016/06/18 06:00 [entrez]
PHST- 2016/06/18 06:00 [pubmed]
PHST- 2017/05/04 06:00 [medline]
AID - 10.1007/s11250-016-1099-1 [pii]
AID - 10.1007/s11250-016-1099-1 [doi]
PST - ppublish
SO  - Trop Anim Health Prod. 2016 Oct;48(7):1351-9. doi: 10.1007/s11250-016-1099-1. 
      Epub 2016 Jun 17.