PMID- 27318433
OWN - NLM
STAT- MEDLINE
DCOM- 20170327
LR  - 20220321
IS  - 1473-0502 (Print)
IS  - 1473-0502 (Linking)
VI  - 55
IP  - 2
DP  - 2016 Oct
TI  - Alloimmunization against platelets, granulocytes and erythrocytes in 
      multi-transfused patients in Iranian population.
PG  - 205-211
LID - S1473-0502(16)30064-7 [pii]
LID - 10.1016/j.transci.2016.06.003 [doi]
AB  - BACKGROUND: This study aims at alloantibody screening, determination of the types 
      of these antibodies in multiple-transfused patients with chronic hematologic 
      diseases. PATIENTS AND METHODS: This descriptive study was performed on 240 
      patients with chronic hematological diseases referred to public hospitals in 
      Iran. Single blood sample was taken and tested for the presence of antibodies. In 
      case of a positive antibody screening, antibody identification was performed 
      using granulocyte agglutination test (GAT), granulocyte indirect 
      immunofluorescence test (GIIFT), platelet indirect immunofluorescence test 
      (PIIFT), monoclonal antibody-specific immobilization of platelet antigen (MAIPA) 
      and panel cells. RESULTS: Out of 240 patients, 105 patients (43.75 %) had been 
      alloimmunized. The incidence of alloantibodies against red blood cells (RBCs) in 
      positive alloantibodies patients were 84.76% (89/105). The most common 
      alloantibody was against antigens of the kell (anti-K) and Rh (anti-E) and (anti 
      D) systems (46.66%, 18.09% and 11.43% respectively). The overall incidence of 
      anti- human leukocyte antigen (HLA) antibodies were 65.7% (69/105). 
      Polymorphonuclear (PMN)-specific antibodies were found in 6.66% (7/105). Also 
      from 105 patients, 14 patients had alloantibodies against platelet. DISCUSSION: 
      In general, it is recommend that to decrease the rate of alloantibody synthesis, 
      the packed cells should be cross matched for minor blood groups especially for Rh 
      (E) and kell. In addition, the use of leukodepleted blood products can decrease 
      the frequency of alloimmunization against platelet (PLT), PMN and HLA antigens.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Younesi, Mohammad Reza
AU  - Younesi MR
AD  - Hematology Department, Allied Medical School, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Louni Aligoudarzi, Samira
AU  - Louni Aligoudarzi S
AD  - Hematology Laboratory, Oncology Ward, Shariati Hospital Tehran, Iran.
FAU - Bigdeli, Razieh
AU  - Bigdeli R
AD  - Department of Genetic, Varamin - Pishva Branch, Islamic Azad University, Tehran, 
      Iran.
FAU - Lashgari, Marzieh
AU  - Lashgari M
AD  - Biochemistry Laboratory, Imam Khomeini Hospital Complex, Vali-e-Asr Hospital, 
      Tehran, Iran.
FAU - Mazaheri, Hoda
AU  - Mazaheri H
AD  - Hematology Laboratory, Oncology Ward, Shariati Hospital Tehran, Iran.
FAU - Asgary, Vahid
AU  - Asgary V
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran. Electronic address: vahid.asgary@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20160614
PL  - England
TA  - Transfus Apher Sci
JT  - Transfusion and apheresis science : official journal of the World Apheresis 
      Association : official journal of the European Society for Haemapheresis
JID - 101095653
RN  - 0 (Isoantibodies)
RN  - 0 (Kell Blood-Group System)
RN  - 0 (Rh-Hr Blood-Group System)
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Platelets/*immunology/metabolism
MH  - Child
MH  - Erythrocytes/*immunology/metabolism
MH  - Female
MH  - Granulocytes/*immunology/metabolism
MH  - Humans
MH  - Isoantibodies/blood/immunology
MH  - Kell Blood-Group System/blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - Rh Isoimmunization/blood/epidemiology/*immunology
MH  - Rh-Hr Blood-Group System/blood/*immunology
MH  - *Transfusion Reaction
OTO - NOTNLM
OT  - Alloimmunization
OT  - Erythrocytes
OT  - Granulocytes
OT  - Multi-transfused patients
OT  - Platelets
EDAT- 2016/10/19 06:00
MHDA- 2017/03/28 06:00
CRDT- 2016/06/20 06:00
PHST- 2016/03/17 00:00 [received]
PHST- 2016/05/13 00:00 [revised]
PHST- 2016/06/10 00:00 [accepted]
PHST- 2016/10/19 06:00 [pubmed]
PHST- 2017/03/28 06:00 [medline]
PHST- 2016/06/20 06:00 [entrez]
AID - S1473-0502(16)30064-7 [pii]
AID - 10.1016/j.transci.2016.06.003 [doi]
PST - ppublish
SO  - Transfus Apher Sci. 2016 Oct;55(2):205-211. doi: 10.1016/j.transci.2016.06.003. 
      Epub 2016 Jun 14.