PMID- 27319049
OWN - NLM
STAT- MEDLINE
DCOM- 20160701
LR  - 20181202
IS  - 0019-5189 (Print)
IS  - 0019-5189 (Linking)
VI  - 54
IP  - 5
DP  - 2016 May
TI  - Sertoli cells promote proliferation of bone marrow-derived mesenchymal stem cells 
      in co-culture.
PG  - 309-14
AB  - Bone marrow-derived mesenchymal stem cells (BMSCs) are a major source for cell 
      transplantation. The proliferative ability of BMSCs is an important determinant 
      of the efficiency of transplant therapy. Sertoli cells are "nurse" cells for 
      development of sperm cells. Our recent study showed that Sertoli cells promoted 
      proliferation of human umbilical cord mesenchymal stem cells (hUCMSCs) in 
      co-culture. Studies by other groups also showed that Sertoli cells promoted 
      growth of endothelial cells and neural stem cells. In this study, we investigated 
      the effect of Sertoli cells on proliferation of BMSCs. Our results showed that 
      Sertoli cells in co-culture significantly enhanced proliferation of BMSCs (P < 
      0.01). Moreover, co-culture with Sertoli cells also markedly increased mRNA 
      and/or protein expressions of Mdm2, p-Akt and Cyclin D1, and decreased p53 
      expression in BMSCs (P < 0.01 or < 0.05). These findings indicate that Sertoli 
      cells have the potential to enhance proliferation of BMSCs.
FAU - Zhang, Fenxi
AU  - Zhang F
FAU - Lu, Ming
AU  - Lu M
FAU - Liu, Hengxing
AU  - Liu H
FAU - Ren, Tongming
AU  - Ren T
FAU - Miao, Yingying
AU  - Miao Y
FAU - Wang, Jingjing
AU  - Wang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Exp Biol
JT  - Indian journal of experimental biology
JID - 0233411
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Cell Cycle Proteins/genetics/metabolism
MH  - *Cell Proliferation
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Gene Expression Regulation
MH  - Male
MH  - Mesenchymal Stem Cells/metabolism/*physiology
MH  - Mice
MH  - *Paracrine Communication
MH  - RNA, Messenger/metabolism
MH  - Sertoli Cells/metabolism/*physiology
MH  - Signal Transduction
EDAT- 2016/06/21 06:00
MHDA- 2016/07/02 06:00
CRDT- 2016/06/21 06:00
PHST- 2016/06/21 06:00 [entrez]
PHST- 2016/06/21 06:00 [pubmed]
PHST- 2016/07/02 06:00 [medline]
PST - ppublish
SO  - Indian J Exp Biol. 2016 May;54(5):309-14.