PMID- 27319396
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20181113
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Print)
IS  - 0890-6238 (Linking)
VI  - 65
DP  - 2016 Oct
TI  - Developmental cigarette smoke exposure II: Hepatic proteome profiles in 6 month 
      old adult offspring.
PG  - 414-424
LID - S0890-6238(16)30148-4 [pii]
LID - 10.1016/j.reprotox.2016.06.009 [doi]
AB  - Utilizing a mouse model of 'active' developmental cigarette smoke exposure (CSE) 
      [gestational day (GD) 1 through postnatal day (PD) 21] characterized by offspring 
      low birth weight, the impact of developmental CSE on liver proteome profiles of 
      adult offspring at 6 months of age was determined. Liver tissue was collected 
      from Sham- and CSE-offspring for 2D-SDS-PAGE based proteome analysis with Partial 
      Least Squares-Discriminant Analysis (PLS-DA). A similar study conducted at the 
      cessation of exposure to cigarette smoke documented decreased gluconeogenesis 
      coupled to oxidative stress in weanling offspring. In the current study, exposure 
      throughout development to cigarette smoke resulted in impaired hepatic 
      carbohydrate metabolism, decreased serum glucose levels, and increased 
      gluconeogenic regulatory enzyme abundances during the fed-state coupled to 
      decreased expression of SIRT1 as well as increased PEPCK and PGC1alpha expression. 
      Together these findings indicate inappropriately timed gluconeogenesis that may 
      reflect impaired insulin signaling in mature offspring exposed to 'active' 
      developmental CSE.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Neal, Rachel E
AU  - Neal RE
AD  - Department of Environmental and Occupational Health Sciences, School of Public 
      Health and Information Sciences, University of Louisville, Louisville, KY, United 
      States; Birth Defects Center, University of Louisville, Louisville, KY, United 
      States. Electronic address: rachel.neal@louisville.edu.
FAU - Chen, Jing
AU  - Chen J
AD  - Department of Environmental and Occupational Health Sciences, School of Public 
      Health and Information Sciences, University of Louisville, Louisville, KY, United 
      States.
FAU - Webb, Cindy
AU  - Webb C
AD  - Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of 
      Louisville, Louisville, KY, United States.
FAU - Stocke, Kendall
AU  - Stocke K
AD  - Department of Environmental and Occupational Health Sciences, School of Public 
      Health and Information Sciences, University of Louisville, Louisville, KY, United 
      States.
FAU - Gambrell, Caitlin
AU  - Gambrell C
AD  - Department of Environmental and Occupational Health Sciences, School of Public 
      Health and Information Sciences, University of Louisville, Louisville, KY, United 
      States.
FAU - Greene, Robert M
AU  - Greene RM
AD  - Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of 
      Louisville, Louisville, KY, United States; Birth Defects Center, University of 
      Louisville, Louisville, KY, United States.
FAU - Pisano, M Michele
AU  - Pisano MM
AD  - Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of 
      Louisville, Louisville, KY, United States; Birth Defects Center, University of 
      Louisville, Louisville, KY, United States.
LA  - eng
GR  - P20 RR017702/RR/NCRR NIH HHS/United States
GR  - P30 ES014443/ES/NIEHS NIH HHS/United States
GR  - R21 DA027466/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20160616
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Amino Acids)
RN  - 0 (Blood Glucose)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Proteome)
RN  - 0 (Smoke)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 4964P6T9RB (Aldosterone)
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Aldosterone/metabolism
MH  - Amino Acids/metabolism
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Carbohydrate Metabolism
MH  - Cytoskeletal Proteins/metabolism
MH  - Female
MH  - Glutathione/metabolism
MH  - Glutathione Reductase/metabolism
MH  - Glutathione Transferase/metabolism
MH  - Lipid Metabolism
MH  - Liver/*drug effects/metabolism
MH  - Maternal Exposure/adverse effects
MH  - Maternal-Fetal Exchange
MH  - Mice, Inbred C57BL
MH  - Oxidative Stress
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced
MH  - Proteome/*drug effects
MH  - Smoke/*adverse effects
MH  - *Tobacco Products
MH  - Tobacco Smoke Pollution/*adverse effects
PMC - PMC5096382
MID - NIHMS806555
OTO - NOTNLM
OT  - Cigarette smoke
OT  - Developmental
OT  - Liver
OT  - Murine
OT  - Proteome
OT  - Tobacco
EDAT- 2016/06/21 06:00
MHDA- 2018/01/09 06:00
PMCR- 2017/10/01
CRDT- 2016/06/21 06:00
PHST- 2015/07/23 00:00 [received]
PHST- 2016/06/10 00:00 [revised]
PHST- 2016/06/14 00:00 [accepted]
PHST- 2016/06/21 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
PHST- 2016/06/21 06:00 [entrez]
PHST- 2017/10/01 00:00 [pmc-release]
AID - S0890-6238(16)30148-4 [pii]
AID - 10.1016/j.reprotox.2016.06.009 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2016 Oct;65:414-424. doi: 10.1016/j.reprotox.2016.06.009. Epub 
      2016 Jun 16.