PMID- 27319980
OWN - NLM
STAT- MEDLINE
DCOM- 20180201
LR  - 20191210
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 44
IP  - 4
DP  - 2016 Aug
TI  - Inhibitory effect of intensity and interstimulus interval of conditioning stimuli 
      on somatosensory evoked magnetic fields.
PG  - 2104-13
LID - 10.1111/ejn.13317 [doi]
AB  - Magnetoencephalography (MEG) recordings were performed to investigate the 
      inhibitory effects of conditioning stimuli with various types of interstimulus 
      intervals (ISIs) or intensities on somatosensory evoked magnetic fields (SEFs) 
      using a 306-ch whole-head MEG system. Twenty-three healthy volunteers 
      participated in this study. Electrical stimuli were applied to the right median 
      nerve at the wrist. Six pulse trains with ISIs of 500 ms were presented in 
      Experiment 1. A paired-pulse paradigm with three kinds of conditioning stimulus 
      (CON) intensities, 500 ms before the test stimulus (TS), was applied in 
      Experiment 2. Finally, three CONs 500 or 1000 ms before TS were presented in 
      Experiment 3. Three main SEF deflections (N20m, P35m, and P60m) were observed, 
      and the source activities of P35m and P60m significantly decreased after the 2nd 
      pulse of a six pulse trains. These source activities also significantly decreased 
      with increasing intensity of CON. In addition, these attenuations of source 
      activities were affected by CON-CON or CON-TS intervals. These results indicated 
      that the source activities were modulated by the intensity and ISIs of CONs. 
      Furthermore, P35m after the stimulation were very sensitive to CONs; however, the 
      attenuation of P60m after the stimulation lasted for a longer period than that of 
      P35m. Our findings suggest that the conditioning stimulation had inhibitory 
      effects on subsequent evoked cortical responses for more than 500 ms. Our results 
      also provide important clues about the nature of short-latency somatosensory 
      responses in human studies.
CI  - (c) 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Onishi, Hideaki
AU  - Onishi H
AD  - Institute for human movement and medical sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Sugawara, Kazuhiro
AU  - Sugawara K
AD  - Institute for human movement and medical sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Yamashiro, Koya
AU  - Yamashiro K
AD  - Institute for human movement and medical sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Sato, Daisuke
AU  - Sato D
AD  - Institute for human movement and medical sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Kirimoto, Hikari
AU  - Kirimoto H
AD  - Institute for human movement and medical sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Tamaki, Hiroyuki
AU  - Tamaki H
AD  - Institute for human movement and medical sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Shirozu, Hiroshi
AU  - Shirozu H
AD  - Department of Neurosurgery, Nishi-Niigata Chuo National Hospital, Niigata, Japan.
FAU - Kameyama, Shigeki
AU  - Kameyama S
AD  - Department of Neurosurgery, Nishi-Niigata Chuo National Hospital, Niigata, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160711
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Adult
MH  - Conditioning, Psychological
MH  - *Electric Stimulation/methods
MH  - Evoked Potentials, Somatosensory/*physiology
MH  - Female
MH  - Humans
MH  - *Magnetic Fields
MH  - Magnetoencephalography/methods
MH  - Male
MH  - Median Nerve/physiology
MH  - Reaction Time/physiology
MH  - Somatosensory Cortex/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - electrical stimulation
OT  - magnetoencephalography
OT  - prepulse inhibition
OT  - somatosensory cortex
EDAT- 2016/06/21 06:00
MHDA- 2018/02/02 06:00
CRDT- 2016/06/21 06:00
PHST- 2016/01/27 00:00 [received]
PHST- 2016/06/14 00:00 [revised]
PHST- 2016/06/16 00:00 [accepted]
PHST- 2016/06/21 06:00 [entrez]
PHST- 2016/06/21 06:00 [pubmed]
PHST- 2018/02/02 06:00 [medline]
AID - 10.1111/ejn.13317 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2016 Aug;44(4):2104-13. doi: 10.1111/ejn.13317. Epub 2016 Jul 11.