PMID- 27320571
OWN - NLM
STAT- MEDLINE
DCOM- 20170105
LR  - 20181202
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 48
IP  - 4
DP  - 2016 May
TI  - Role of Human Leukocyte Antigen Compatibility in Graft Outcomes After Living 
      Donor Liver Transplantation.
PG  - 1123-9
LID - S0041-1345(16)00171-8 [pii]
LID - 10.1016/j.transproceed.2016.01.018 [doi]
AB  - PURPOSE: The influence of human leukocyte antigen (HLA) mismatch on liver 
      transplantation has been widely studied, but is still controversial. The aim of 
      this large single-center study was to analyze the role of HLA compatibility 
      between donor and recipient in the graft outcomes of living donor liver 
      transplantation (LDLT). MATERIALS AND METHODS: A total of 925 recipients who had 
      undergone LDLT between March 2001 and April 2012 were retrospectively analyzed. 
      HLA typing was performed using a standard complement-dependent cytotoxicity 
      technique. The degree and type of HLA-A, HLA-B, and HLA-DR mismatch were 
      assessed. We also investigated the posttransplantation laboratory data, incidence 
      of rejection, recurrence of hepatitis B virus (HBV), and graft survival as 
      outcome parameters. RESULTS: The type of HLA-A, HLA-B, and HLA-DR mismatch had no 
      effect on rejection episodes, whereas the beneficial effect of a much lower 
      degree (0-2) of HLA mismatch was notable. Recipients with 2 HLA-B mismatches or 
      recipients with a higher degree of mismatch were associated with elevated 
      bilirubin level, a higher recurrence rate of HBV, and inferior graft survival. A 
      complete mismatch of 2 at the DR locus also decreased graft survival in LDLT 
      recipients. CONCLUSIONS: This study confirmed that the degree of HLA mismatch, as 
      well as the locus-specific type of HLA mismatch, namely B and DR, play a major 
      role in graft outcomes after LDLT. To obtain an improved graft outcome, HLA 
      compatibility should be considered in the setting of LDLT, which provides 
      sufficient time to select a more favorable donor-recipient combination.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Shin, M
AU  - Shin M
AD  - Department of Surgery, Konkuk University Medical Center, Konkuk University School 
      of Medicine, Seoul, Korea.
FAU - Kim, J M
AU  - Kim JM
AD  - Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, Korea.
FAU - Kwon, C H D
AU  - Kwon CH
AD  - Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, Korea.
FAU - Kim, S-J
AU  - Kim SJ
AD  - Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, Korea.
FAU - Joh, J-W
AU  - Joh JW
AD  - Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, Korea. Electronic address: jw.joh@samsung.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Female
MH  - Graft Rejection/epidemiology/*immunology
MH  - Graft Survival/*immunology
MH  - HLA Antigens/*immunology
MH  - HLA-A Antigens/immunology
MH  - HLA-B Antigens/immunology
MH  - HLA-DR Antigens/immunology
MH  - Hepatitis B
MH  - Histocompatibility Testing
MH  - Humans
MH  - Incidence
MH  - *Liver Transplantation
MH  - *Living Donors
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2016/06/21 06:00
MHDA- 2017/01/06 06:00
CRDT- 2016/06/21 06:00
PHST- 2015/11/02 00:00 [received]
PHST- 2016/01/08 00:00 [revised]
PHST- 2016/01/21 00:00 [accepted]
PHST- 2016/06/21 06:00 [entrez]
PHST- 2016/06/21 06:00 [pubmed]
PHST- 2017/01/06 06:00 [medline]
AID - S0041-1345(16)00171-8 [pii]
AID - 10.1016/j.transproceed.2016.01.018 [doi]
PST - ppublish
SO  - Transplant Proc. 2016 May;48(4):1123-9. doi: 10.1016/j.transproceed.2016.01.018.